ENSMUSG00000051056


Mus musculus

Features
Gene ID: ENSMUSG00000051056
  
Biological name :Gja10
  
Synonyms : gap junction protein, alpha 10 / Gja10 / Q9WUS4
  
Possible biological names infered from orthology : Q969M2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 32596960
Gene end: 32602760
  
Corresponding Affymetrix probe sets: 10511898 (MoGene1.0st)   1422328_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061742
Ensembl peptide - ENSMUSP00000151323
NCBI entrez gene - 14610     See in Manteia.
MGI - MGI:1339969
RefSeq - NM_010289
RefSeq Peptide - NP_034419
swissprot - Q9WUS4
Ensembl - ENSMUSG00000051056
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cx52.6ENSDARG00000034930Danio rerio
 cx52.7ENSDARG00000057792Danio rerio
 GJA10ENSGALG00000015606Gallus gallus
 GJA10ENSG00000135355Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gja8 / P28236 / gap junction protein, alpha 8 / P48165*ENSMUSG0000004990829
Gja3 / Q64448 / gap junction protein, alpha 3 / Q9Y6H8*ENSMUSG0000004858228
Gja5 / Q01231 / gap junction protein, alpha 5 / P36382*ENSMUSG0000005712327
Gja4 / P28235 / gap junction protein, alpha 4 / P35212*ENSMUSG0000005023427
Gja1 / P23242 / gap junction protein, alpha 1 / P17302*ENSMUSG0000005095326
Gja6 / Q6S5G4 / gap junction protein, alpha 6ENSMUSG0000005569123
Gjc1 / P28229 / gap junction protein, gamma 1 / P36383*ENSMUSG0000003452023
Gjc2 / Q8BQU6 / gap junction protein, gamma 2 / Q5T442*ENSMUSG0000004344821
Gjd2 / O54851 / gap junction protein, delta 2 / Q9UKL4*ENSMUSG0000006861520
Gjd3 / Q91YD1 / gap junction protein, delta 3 / Q8N144*ENSMUSG0000004719717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000500  Connexin
 IPR013092  Connexin, N-terminal
 IPR017990  Connexin, conserved site
 IPR019570  Gap junction protein, cysteine-rich domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007276 gamete generation IDA
 biological_processGO:0007416 synapse assembly IMP
 biological_processGO:0009416 response to light stimulus IMP
 biological_processGO:0050908 detection of light stimulus involved in visual perception IMP
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0005922 connexin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005243 gap junction channel activity IDA


Pathways (from Reactome)
Pathway description
Electric Transmission Across Gap Junctions
Gap junction assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001005 abnormal rod morphology "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

 MP:0001006 abnormal cone morphology "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Bmpr2tm1.1Enl/Bmpr2tm1.2Enl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bmpr2tm1.1Enl/Bmpr2tm1.2Enl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Msh2tm1Mak/Msh2tm1Mak,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Gja10tm1Kwi/Gja10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gja10tm2(HBEGF/EGFP)Kwi/Gja10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006068 abnormal horizontal cell morphology "anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Msh2tm1Mak/Msh2tm1Mak,Mutyhtm1Jhmi/Mutyhtm1Jhmi,Ogg1tm1Tld/Ogg1tm1Tld
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Gja10tm1Kwi/Gja10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
Show

Allelic Composition: Gja10tm2(HBEGF/EGFP)Kwi/Gja10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008519 thin retinal outer plexiform layer "reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gja10tm2(HBEGF/EGFP)Kwi/Gja10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008520 disorganized retinal outer plexiform layer "a derangement of the normal pattern of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gja10tm2(HBEGF/EGFP)Kwi/Gja10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000051056 Gja10 / Q9WUS4 / gap junction protein, alpha 10 / Q969M2*  / complex






 

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