MP:0000267 | abnormal cardiac development | "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370] |
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt
Allelic Composition: Gjc1tm1Kni/Gjc1tm1Kni Genetic Background: involves: 129S/SvEv * C57BL/6
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MP:0000269 | abnormal looping morphogenesis | "atypical bending of the primitive heart tube during early development" [J:27443] |
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt
Allelic Composition: Gjc1tm1Kni/Gjc1tm1Kni Genetic Background: involves: 129S/SvEv * C57BL/6
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MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt
Allelic Composition: Gjc1tm1Kni/Gjc1tm1Kni Genetic Background: involves: 129S/SvEv * C57BL/6
Allelic Composition: Gjc1tm1.1(Gjd2)Kwi/Gjc1tm1.1(Gjd2)Kwi,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Allelic Composition: Gjc1tm1.2(Gjd2)Kwi/Gjc1tm1.2(Gjd2)Kwi Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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MP:0000288 | abnormal pericardium morphology | "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408] |
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+ Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics
Allelic Composition: Gjc1tm1.1(KOMP)Vlcg/Gjc1+ Genetic Background: C57BL/6N-Gjc1tm1.1(KOMP)Vlcg/Ucd
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MP:0000296 | absent ventricular trabeculae | "missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:45302] |
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt
Allelic Composition: Gjc1tm1Kni/Gjc1tm1Kni Genetic Background: involves: 129S/SvEv * C57BL/6
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MP:0000297 | abnormal endocardial cushion morphology | "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1(cre/ERT2)Blh/Sftpc+,Trp53tm5Tyj/Trp53+ Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
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MP:0000298 | absent endocardial cushion | "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS] |
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt
Allelic Composition: Gjc1tm1Kni/Gjc1tm1Kni Genetic Background: involves: 129S/SvEv * C57BL/6
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MP:0001606 | impaired hematopoiesis | "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Nkx3-2tm1Bobh/Nkx3-2tm1Bobh,Nkx3-1tm1Hha/Nkx3-1tm1Hha Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Gjc1tm2.1Kni/Gjc1tm2.1Kni Genetic Background: Not Specified
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MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt
Allelic Composition: Gjc1tm1Kni/Gjc1tm1Kni Genetic Background: involves: 129S/SvEv * C57BL/6
Allelic Composition: Gjc1tm1.1(Gjd2)Kwi/Gjc1tm1.1(Gjd2)Kwi,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Allelic Composition: Gjc1tm1.2(Gjd2)Kwi/Gjc1tm1.2(Gjd2)Kwi Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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MP:0001730 | embryonic growth arrest | "the cessation of development beyond a particular stage" [J:17509] |
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt
Allelic Composition: Gjc1tm1Kni/Gjc1tm1Kni Genetic Background: involves: 129S/SvEv * C57BL/6
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MP:0002652 | thin myocardial wall | "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Nkx3-2tm1Bobh/Nkx3-2tm1Bobh,Nkx3-1tm1Hha/Nkx3-1tm1Hha Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Gjc1tm2.1Kni/Gjc1tm2.1Kni Genetic Background: Not Specified
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MP:0003137 | abnormal impulse conducting system conduction | "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Nkx3-2tm1Bobh/Nkx3-2tm1Bobh,Nkx3-1tm1Hha/Nkx3-1tm1Hha Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Gjc1tm1.1(Gjd2)Kwi/Gjc1tm1.1(Gjd2)Kwi,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
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MP:0003231 | abnormal placental vasculature | "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157] |
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Allelic Composition: Nkx3-2tm1Bobh/Nkx3-2tm1Bobh,Nkx3-1tm1Hha/Nkx3-1tm1Hha Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
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MP:0003393 | decreased cardiac output | "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Nkx3-2tm1Bobh/Nkx3-2tm1Bobh,Nkx3-1tm1Hha/Nkx3-1tm1Hha Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Allelic Composition: Gjc1tm2.1Kni/Gjc1tm2.1Kni Genetic Background: Not Specified
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MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gjc1tm1.1(Gjd2)Kwi/Gjc1tm1.1(Gjd2)Kwi,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Allelic Composition: Gjc1tm1.2(Gjd2)Kwi/Gjc1tm1.2(Gjd2)Kwi Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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MP:0004259 | small placenta | "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt
Allelic Composition: Gjc1tm1Kni/Gjc1tm1Kni Genetic Background: involves: 129S/SvEv * C57BL/6
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MP:0004937 | dilated heart | "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gjc1tm1.1(Gjd2)Kwi/Gjc1tm1.1(Gjd2)Kwi,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
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MP:0005140 | decreased cardiac muscle contractility | "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt
Allelic Composition: Gjc1tm1Kni/Gjc1tm1Kni Genetic Background: involves: 129S/SvEv * C57BL/6
Allelic Composition: Gjc1tm1.1(Gjd2)Kwi/Gjc1tm1.1(Gjd2)Kwi,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Allelic Composition: Gjc1tm1.2(Gjd2)Kwi/Gjc1tm1.2(Gjd2)Kwi Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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MP:0005253 | abnormal eye physiology | "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Slc18a2tm1Edw/Slc18a2+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0005312 | pericardial effusion | "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gjc1tm1.1(Gjd2)Kwi/Gjc1tm1.1(Gjd2)Kwi,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
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MP:0005333 | decreased heart rate | "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764] |
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Allelic Composition: Gjc1tm1.1(Gjd2)Kwi/Gjc1tm1.1(Gjd2)Kwi,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
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MP:0005385 | cardiovascular system phenotype | |
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+ Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics
Allelic Composition: Gjc1tm1.1(KOMP)Vlcg/Gjc1+ Genetic Background: C57BL/6N-Gjc1tm1.1(KOMP)Vlcg/Ucd
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MP:0005551 | abnormal eye electrophysiology | "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
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Allelic Composition: Slc18a2tm1Edw/Slc18a2+ Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Gjc1tm1Kwi/Gjc1tm1Weil,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt
Allelic Composition: Gjc1tm1Kni/Gjc1tm1Kni Genetic Background: involves: 129S/SvEv * C57BL/6
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MP:0006138 | congestive heart failure | "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gjc1tm1.1(Gjd2)Kwi/Gjc1tm1.1(Gjd2)Kwi,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
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MP:0006142 | abnormal sinoatrial node conduction | "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Wwtr1tm1.2Eno/Wwtr1tm1.2Eno Genetic Background: involves: 129S/SvEv
Allelic Composition: Gjc1tm1Kwi/Gjc1tm1Kwi,Tg(Myh6-icre/ERT2)#Wet/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0010508 | abnormal heart electrocardiography waveform feature | "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536] |
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Allelic Composition: Wwtr1tm1.2Eno/Wwtr1tm1.2Eno Genetic Background: involves: 129S/SvEv
Allelic Composition: Gjc1tm1Kwi/Gjc1tm1Kwi,Tg(Myh6-icre/ERT2)#Wet/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0010519 | atrioventricular block | "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gjc1tm1.1(Gjd2)Kwi/Gjc1tm1.1(Gjd2)Kwi,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
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MP:0010559 | heart block | "a partial or complete obstruction of the propogation of electric impulses through the impulse conduction system of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt
Allelic Composition: Gjc1tm1Kni/Gjc1tm1Kni Genetic Background: involves: 129S/SvEv * C57BL/6
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MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Egfrwa2/Egfrwa2,Sos1tm1Dlb/Sos1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn-a/A-Egfrwa2 Wnt3avt
Allelic Composition: Gjc1tm1Kni/Gjc1tm1Kni Genetic Background: involves: 129S/SvEv * C57BL/6
Allelic Composition: Gjc1tm2Kni/Gjc1tm2Kni,Tg(ACTC1-cre)1Miwa/0 Genetic Background: involves: C57BL/6 * DBA
Allelic Composition: Gjc1tm1.1(Gjd2)Kwi/Gjc1tm1.1(Gjd2)Kwi,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Allelic Composition: Gjc1tm1.2(Gjd2)Kwi/Gjc1tm1.2(Gjd2)Kwi Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
Allelic Composition: Gjc1tm1Kwi/Gjc1tm1Kwi,Tg(Myh6-icre/ERT2)#Wet/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0011953 | prolonged PQ interval | "increase in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly] |
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Allelic Composition: Gjc1tm1Kwi/Gjc1tm1Kwi,Gjd3tm2.1Kwi/Gjd3tm2.1Kwi,Tg(Myh6-icre/ERT2)#Wet/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Allelic Composition: Gjc1tm1Kwi/Gjc1tm1Kwi,Tg(Myh6-icre/ERT2)#Wet/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0012701 | increased embryonic neuroepithelium apoptosis | "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna] |
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Allelic Composition: Gjc1tm2Kni/Gjc1tm2Kni,Tg(ACTC1-cre)1Miwa/0 Genetic Background: involves: C57BL/6 * DBA
Allelic Composition: Gjc1tm2.1Kni/Gjc1tm2.1Kni Genetic Background: Not Specified
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MP:0013293 | embryonic lethality prior to tooth bud stage | "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb] |
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+ Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics
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