ENSMUSG00000000552


Mus musculus

Features
Gene ID: ENSMUSG00000000552
  
Biological name :Zfp385a
  
Synonyms : Q8VD12 / Zfp385a / zinc finger protein 385A
  
Possible biological names infered from orthology : Q96PM9 / ZNF385A
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F3
Gene start: 103313895
Gene end: 103340093
  
Corresponding Affymetrix probe sets: 10433104 (MoGene1.0st)   1418865_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130176
Ensembl peptide - ENSMUSP00000155498
Ensembl peptide - ENSMUSP00000155501
NCBI entrez gene - 29813     See in Manteia.
MGI - MGI:1352495
RefSeq - XM_011245656
RefSeq - NM_001356627
RefSeq - NM_013866
RefSeq - XM_006521055
RefSeq - XM_006521056
RefSeq - XM_006521057
RefSeq - XM_006521053
RefSeq - XM_006521054
RefSeq Peptide - NP_038894
RefSeq Peptide - NP_001343556
swissprot - Q8VD12
Ensembl - ENSMUSG00000000552
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 znf385aENSDARG00000009899Danio rerio
 ENSGALG00000046448Gallus gallus
 Q96PM9ENSG00000161642Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BXJ8 / Zfp385b / zinc finger protein 385B / Q569K4* / ZNF385B*ENSMUSG0000002701648
A2A5E6 / Zfp385c / zinc finger protein 385C / ZNF385C*ENSMUSG0000001419842


Protein motifs (from Interpro)
Interpro ID Name
 IPR003604  Matrin/U1-C-like, C2H2-type zinc finger
 IPR013087  Zinc finger C2H2-type
 IPR026939  At2g23090-like
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007599 hemostasis IMP
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008298 intracellular mRNA localization IMP
 biological_processGO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression IMP
 biological_processGO:0030220 platelet formation IMP
 biological_processGO:0035855 megakaryocyte development IMP
 biological_processGO:0045600 positive regulation of fat cell differentiation IMP
 biological_processGO:0070889 platelet alpha granule organization IMP
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IBA
 biological_processGO:1902164 positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IEA
 biological_processGO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:2000765 regulation of cytoplasmic translation IMP
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Association with Co-factors
Transcriptional activation of cell cycle inhibitor p21


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrg1tm2Zhou/Nrg1tm2Zhou
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0020431 decreased platelet alpha-granule number "decreased number of platelet alpha-granules" []
Show

Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / complex / reaction






 

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