ENSMUSG00000000731


Mus musculus

Features
Gene ID: ENSMUSG00000000731
  
Biological name :Aire
  
Synonyms : Aire / Autoimmune regulator / Q9Z0E3
  
Possible biological names infered from orthology : O43918
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 78030022
Gene end: 78043610
  
Corresponding Affymetrix probe sets: 10370397 (MoGene1.0st)   1419241_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122190
Ensembl peptide - ENSMUSP00000121477
Ensembl peptide - ENSMUSP00000122659
Ensembl peptide - ENSMUSP00000123678
Ensembl peptide - ENSMUSP00000019257
Ensembl peptide - ENSMUSP00000101034
Ensembl peptide - ENSMUSP00000101035
Ensembl peptide - ENSMUSP00000114808
Ensembl peptide - ENSMUSP00000114904
Ensembl peptide - ENSMUSP00000115162
Ensembl peptide - ENSMUSP00000117094
Ensembl peptide - ENSMUSP00000118317
Ensembl peptide - ENSMUSP00000120150
NCBI entrez gene - 11634     See in Manteia.
MGI - MGI:1338803
RefSeq - NM_001271559
RefSeq - NM_001271549
RefSeq - NM_001271550
RefSeq - NM_001271551
RefSeq - NM_001271552
RefSeq - NM_001271553
RefSeq - NM_001271554
RefSeq - NM_001271555
RefSeq - NM_001271556
RefSeq - NM_001271557
RefSeq - NM_001271558
RefSeq - NM_009646
RefSeq - XM_011243277
RefSeq Peptide - NP_001258486
RefSeq Peptide - NP_001258487
RefSeq Peptide - NP_001258488
RefSeq Peptide - NP_033776
RefSeq Peptide - NP_001258480
RefSeq Peptide - NP_001258481
RefSeq Peptide - NP_001258478
RefSeq Peptide - NP_001258479
RefSeq Peptide - NP_001258482
RefSeq Peptide - NP_001258483
RefSeq Peptide - NP_001258484
RefSeq Peptide - NP_001258485
swissprot - Q3ZB71
swissprot - Q9Z0E3
swissprot - E9Q441
swissprot - D6RDQ5
swissprot - Q3ZB65
swissprot - B2MVU6
Ensembl - ENSMUSG00000000731
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aireENSDARG00000056784Danio rerio
 AIREENSG00000160224Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Phf12 / Q5SPL2 / PHD finger protein 12 / Q96QT6*ENSMUSG0000003779116


Protein motifs (from Interpro)
Interpro ID Name
 IPR000770  SAND domain
 IPR001965  Zinc finger, PHD-type
 IPR004865  HSR domain
 IPR008087  Autoimmune regulator, AIRE
 IPR010919  SAND-like domain superfamily
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002458 peripheral T cell tolerance induction IDA
 biological_processGO:0002509 central tolerance induction to self antigen ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006959 humoral immune response IMP
 biological_processGO:0032602 chemokine production IMP
 biological_processGO:0045060 negative thymic T cell selection IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0097536 thymus epithelium morphogenesis IMP
 biological_processGO:2000410 regulation of thymocyte migration IMP
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003712 transcription coregulator activity IBA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0042393 histone binding ISS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS
 molecular_functionGO:0045182 translation regulator activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Airetm1Pltn/Airetm1Pltn
Genetic Background: B6.129S4-Airetm1Pltn

 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Airetm1Mmat/Airetm1Mmat
Genetic Background: C.Cg-Airetm1Mmat

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Airetm1Pltn/Airetm1Pltn
Genetic Background: B6.129S4-Airetm1Pltn

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Atp7aMo-dp2/Y
Genetic Background: Not Specified

Allelic Composition: Airetm1Mmat/Airetm2Mmat
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Airetm1Mmat/Airetm2Mmat,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Airetm1Mand/Airetm1Mand
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Airetm1Mand/Aire+
Genetic Background: NOD.129P2-Airetm1Mand

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Airetm1Mand/Aire+
Genetic Background: NOD.129P2-Airetm1Mand

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Thl/Trp53tm1Thl,Tyrc-Brd/Tyrc-Brd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2-Airetm1.1Doi

 MP:0001313 increased incidence of corneal inflammation "greater than average and persistent occurrence of corneal irritation" [J:4606]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2(B6)-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: C.129S2-Airetm1.1Doi/Doi

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: B6.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2(B6)-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: C.129S2-Airetm1.1Doi/Doi

 MP:0001337 dry eyes "absence of natural or normal moisture in the eye" [J:53284]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

 MP:0001346 abnormal lacrimal gland morphology "malformation of the glands that secrete tears" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Airetm1Mand/Airetm1Mand
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Thl/Trp53tm1Thl,Tyrc-Brd/Tyrc-Brd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk,Tg(Myh6-NFATC4)#Eno/?
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Airetm1Mmat/Airetm1Mmat
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Airetm1Mmat/Airetm1Mmat
Genetic Background: B6.Cg-Airetm1Mmat

Allelic Composition: Airetm2Mmat/Airetm2Mmat
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Airetm1Mmat/Airetm2Mmat
Genetic Background: involves: C57BL/6 * CBA

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Airetm1Mand/Airetm1Mand
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001851 eye inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Airetm1Mand/Aire+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2(B6)-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: C.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: SJL.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD

Allelic Composition: Airetm1Pltn/Airetm1Pltn
Genetic Background: B6.129S4-Airetm1Pltn

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: B6.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2(B6)-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: C.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: SJL.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2-Airetm1.1Doi

Allelic Composition: Airetm1Mand/Airetm1.1Doi
Genetic Background: NOD.129-Airetm1Mand/Airetm1.1Doi

 MP:0001868 ovary inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the ovary" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2(B6)-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: C.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: SJL.129S2-Airetm1.1Doi/Doi

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Airetm1Mmat/Airetm1Mmat
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2(B6)-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: SJL.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Spi1tm1Ram/Spi1tm1Ram,Tg(SOD1*G93A)1Gur/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2(B6)-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: C.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: SJL.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD

Allelic Composition: Airetm1Mand/Aire+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Airetm1Mand/Airetm1Mand
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Airetm1Mand/Aire+
Genetic Background: NOD.129P2-Airetm1Mand

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2-Airetm1.1Doi

Allelic Composition: Airetm1Mand/Airetm1.1Doi
Genetic Background: NOD.129-Airetm1Mand/Airetm1.1Doi

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

Allelic Composition: Airetm1Mmat/Airetm1Mmat
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Airetm1Mmat/Airetm1Mmat
Genetic Background: C.Cg-Airetm1Mmat

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: B6.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2(B6)-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: C.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: SJL.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,H2b/H2b
Genetic Background: NOD.Cg-Airetm1.1Doi H2b/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Idd3C57BL/6/Idd3C57BL/6,Idd5C57BL/10SnJ/Idd5C57BL/10SnJ
Genetic Background: NOD.Cg-Idd3C57BL/6 Idd5C57BL/10SnJ Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2-Airetm1.1Doi

Allelic Composition: Airetm1Mand/Airetm1.1Doi
Genetic Background: NOD.129-Airetm1Mand/Airetm1.1Doi

Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Agrptm1Sqn/Agrptm1Sqn,Npytm1Rpa/Npytm1Rpa
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Airetm1Mmat/Airetm1Mmat
Genetic Background: involves: C57BL/6 * CBA

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk,Tg(Myh6-NFATC4)#Eno/?
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Airetm1Pltn/Airetm1Pltn
Genetic Background: B6.129S4-Airetm1Pltn

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: B6.129S2-Airetm1.1Doi/Doi

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+,Ptentm1Hwu/Ptentm1Hwu,Trp53tm1Thl/Trp53tm1Thl,Tyrc-Brd/Tyrc-Brd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Airetm1Mand/Airetm1.1Doi
Genetic Background: NOD.129-Airetm1Mand/Airetm1.1Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Tg(Ins2-TFRC/OVA)296Wehi/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sema3am808Ddg/Sema3atm1Mcf
Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Airetm1Pltn/Airetm1Pltn
Genetic Background: B6.129S4-Airetm1Pltn

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C57BL/6-Airetm1Ptsn

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Airetm1Mand/Aire+
Genetic Background: NOD.129P2-Airetm1Mand

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,H2b/H2b
Genetic Background: NOD.Cg-Airetm1.1Doi H2b/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Idd3C57BL/6/Idd3C57BL/6,Idd5C57BL/10SnJ/Idd5C57BL/10SnJ
Genetic Background: NOD.Cg-Idd3C57BL/6 Idd5C57BL/10SnJ Airetm1.1Doi/Doi

 MP:0003341 chronic pancreas inflammation "persistant inflammatory response in the pancreas, often caused by persistant infection or during an autoimmune response" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Airetm1Mand/Aire+
Genetic Background: NOD.129P2-Airetm1Mand

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2-Airetm1.1Doi

Allelic Composition: Airetm1Mand/Airetm1.1Doi
Genetic Background: NOD.129-Airetm1Mand/Airetm1.1Doi

 MP:0003504 thyroid inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the thyroid gland" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2(B6)-Airetm1.1Doi/Doi

Allelic Composition: Airetm1Mand/Aire+
Genetic Background: NOD.129P2-Airetm1Mand

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2-Airetm1.1Doi

Allelic Composition: Airetm1Mand/Airetm1.1Doi
Genetic Background: NOD.129-Airetm1Mand/Airetm1.1Doi

 MP:0003608 prostate inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the prostate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2(B6)-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: C.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: SJL.129S2-Airetm1.1Doi/Doi

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Airetm1Mand/Aire+
Genetic Background: NOD.129P2-Airetm1Mand

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Airetm1Mmat/Airetm1Mmat
Genetic Background: C.Cg-Airetm1Mmat

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: B6.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2(B6)-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: C.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: SJL.129S2-Airetm1.1Doi/Doi

Allelic Composition: Airetm1Mand/Aire+
Genetic Background: NOD.129P2-Airetm1Mand

Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C57BL/6-Airetm1Ptsn

 MP:0003763 abnormal thymus physiology "anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Airetm2Mmat/Airetm2Mmat
Genetic Background: involves: C57BL/6 * CBA

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Airetm1Mand/Aire+
Genetic Background: NOD.129P2-Airetm1Mand

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2-Airetm1.1Doi

Allelic Composition: Airetm1Mand/Airetm1.1Doi
Genetic Background: NOD.129-Airetm1Mand/Airetm1.1Doi

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Airetm1Mand/Aire+
Genetic Background: NOD.129P2-Airetm1Mand

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Airetm1Pltn/Airetm1Pltn
Genetic Background: B6.129S4-Airetm1Pltn

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cttntm1.2Dvst/Cttn+
Genetic Background: B6.Cg-Cttntm1.2Dvst

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Airetm1Pltn/Airetm1Pltn
Genetic Background: B6.129S4-Airetm1Pltn

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2(B6)-Airetm1.1Doi/Doi

 MP:0005313 absent adrenal gland "missing endocrine glands that are normally located above the kidney and responsible for hormone and epinepherine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56651]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

 MP:0005398 decreased susceptibility to fungal infection "reduced likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Airetm1Mand/Aire+
Genetic Background: NOD.129P2-Airetm1Mand

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2-Airetm1.1Doi

Allelic Composition: Airetm1Mand/Airetm1.1Doi
Genetic Background: NOD.129-Airetm1Mand/Airetm1.1Doi

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

 MP:0005515 uveitis "inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2-Airetm1.1Doi

Allelic Composition: Airetm1Mand/Airetm1.1Doi
Genetic Background: NOD.129-Airetm1Mand/Airetm1.1Doi

Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C57BL/6-Airetm1Ptsn

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

 MP:0006082 CNS inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
Show

Allelic Composition: Airetm1Mand/Aire+
Genetic Background: NOD.129P2-Airetm1Mand

 MP:0006194 keratoconjunctivitis "inflammation of the conjunctiva and cornea" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

 MP:0006201 vitreous body inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the vitreous body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C57BL/6-Airetm1Ptsn

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Tg(Ins2-TFRC/OVA)296Wehi/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cttntm1.2Dvst/Cttn+
Genetic Background: B6.Cg-Cttntm1.2Dvst

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cttntm1.2Dvst/Cttn+
Genetic Background: B6.Cg-Cttntm1.2Dvst

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Airetm1Pltn/Airetm1Pltn
Genetic Background: B6.129S4-Airetm1Pltn

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Airetm1Pltn/Airetm1Pltn
Genetic Background: B6.129S4-Airetm1Pltn

 MP:0008241 abnormal metallophilic macrophage morphology "any structural anomaly of the macrophage cells that surround the white pulp of the spleen, adjacent to the marginal sinus" [PMID:16322748]
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Allelic Composition: Airetm1Pltn/Airetm1Pltn
Genetic Background: B6.129S4-Airetm1Pltn

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

 MP:0008690 increased interleukin-23 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
Show

Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Airetm1Mand/Aire+
Genetic Background: NOD.129P2-Airetm1Mand

 MP:0008879 submandibular gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Airetm1Mmat/Airetm1Mmat
Genetic Background: involves: C57BL/6 * CBA

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Airetm1Mmat/Airetm1Mmat
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Airetm1Mand/Aire+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Airetm1Mand/Airetm1Mand
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Airetm1Mand/Aire+
Genetic Background: NOD.129P2-Airetm1Mand

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi
Genetic Background: NOD.129S2-Airetm1.1Doi

Allelic Composition: Airetm1Mand/Airetm1.1Doi
Genetic Background: NOD.129-Airetm1Mand/Airetm1.1Doi

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

 MP:0009540 absent Hassall s corpuscle "absence of the small spherical bodies of epithelial cells found in the medulla of the thymus, that are arranged in a concentric pattern around clusters of degenerating lymphocytes, eosinophils and macrophages" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Airetm2Mmat/Airetm2Mmat
Genetic Background: involves: C57BL/6 * CBA

 MP:0010222 abnormal T-helper 17 cell physiology "any functional anomaly of a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C.B6-Airetm1Ptsn

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Airetm1Mmat/Airetm1Mmat
Genetic Background: C.Cg-Airetm1Mmat

 MP:0012164 abnormal conjunctiva goblet cell morphology "any structural anomaly of a goblet cell that is part of the epithelium of the conjunctiva, and is the source of tear mucins which are secreted from it" [MGI:csmith]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1tm1Imx
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

 MP:0013367 parotid gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in either of the largest of the major salivary glands situated below and in front of each ear " [MGI:Anna]
Show

Allelic Composition: Airetm1Mmat/Airetm1Mmat
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C57BL/6-Airetm1Ptsn

 MP:0013533 sublingual gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in either of the small mucin-producing salivary glands located in the floor of the mouth beneath the tongue, anterior to the submandibular gland " [MGI:Anna]
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Allelic Composition: Airetm1Ptsn/Airetm1Ptsn
Genetic Background: C57BL/6-Airetm1Ptsn

 MP:0013754 abnormal ocular surface morphology "any structural anomaly of the integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms" [http://www.medscape.org/viewarticle/702141, ISBN:978-1-4665-6559-3, ISBN:978-3-318-01404-4]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Il1r1tm1Imx/Il1r1+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * NOD

 MP:0020220 decreased tear production "decreased production of the amount of fluid produced in the eye" [GOC:NV]
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Allelic Composition: Airetm1Mmat/Airetm1Mmat
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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