ENSMUSG00000001323


Mus musculus

Features
Gene ID: ENSMUSG00000001323
  
Biological name :Srr
  
Synonyms : Q9QZX7 / Serine racemase / Srr
  
Possible biological names infered from orthology : Q9GZT4
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 74906359
Gene end: 74925948
  
Corresponding Affymetrix probe sets: 10388377 (MoGene1.0st)   1419664_at (Mouse Genome 430 2.0 Array)   1438549_a_at (Mouse Genome 430 2.0 Array)   1438550_x_at (Mouse Genome 430 2.0 Array)   1453421_at (Mouse Genome 430 2.0 Array)   1455045_at (Mouse Genome 430 2.0 Array)   1458393_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120012
Ensembl peptide - ENSMUSP00000118485
Ensembl peptide - ENSMUSP00000119256
Ensembl peptide - ENSMUSP00000067552
Ensembl peptide - ENSMUSP00000104086
Ensembl peptide - ENSMUSP00000104087
Ensembl peptide - ENSMUSP00000113372
NCBI entrez gene - 27364     See in Manteia.
MGI - MGI:1351636
RefSeq - NM_013761
RefSeq - NM_001163311
RefSeq - XM_011249057
RefSeq - XM_017314569
RefSeq - XM_017314570
RefSeq - XM_017314571
RefSeq - XM_017314572
RefSeq - XM_006533457
RefSeq - XM_011249056
RefSeq Peptide - NP_001156783
RefSeq Peptide - NP_038789
swissprot - A8Y5D6
swissprot - Q9QZX7
swissprot - Z4YMF3
Ensembl - ENSMUSG00000001323
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch73-263o4.3ENSDARG00000096207Danio rerio
 si:ch73-263o4.4ENSDARG00000096045Danio rerio
 SRRENSGALG00000003155Gallus gallus
 SRRENSG00000167720Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000634  Serine/threonine dehydratase, pyridoxal-phosphate-binding site
 IPR001926  Pyridoxal-phosphate dependent enzyme
 IPR036052  Tryptophan synthase beta subunit-like PLP-dependent enzyme


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006520 cellular amino acid metabolic process IEA
 biological_processGO:0006563 L-serine metabolic process IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009069 serine family amino acid metabolic process IDA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042866 pyruvate biosynthetic process IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0051289 protein homotetramerization IDA
 biological_processGO:0070178 D-serine metabolic process IEA
 biological_processGO:0070179 D-serine biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045177 apical part of cell IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003941 L-serine ammonia-lyase activity ISO
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0008721 D-serine ammonia-lyase activity IEA
 molecular_functionGO:0016594 glycine binding IDA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0018114 threonine racemase activity IDA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding ISO
 molecular_functionGO:0030378 serine racemase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Serine biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acancmd-Bc/Acancmd-Bc
Genetic Background: BALB/cGaBc

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Tgfbr1tm1Bopa/Tgfbr1+
Genetic Background: B6.Cg-Tgfbr1tm1Bopa ApcMin

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax6Rgsc20/Pax6+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

Allelic Composition: Srrtm1.2Jtc/Srr+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

Allelic Composition: Srrtm1.2Jtc/Srr+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: ApcMin/Apc+,Tgfbr1tm1Bopa/Tgfbr1+
Genetic Background: B6.Cg-Tgfbr1tm1Bopa ApcMin

Allelic Composition: Srrrgsc1872/Srrrgsc1872
Genetic Background: C57BL/6JJcl-Srrrgsc1872

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Tgfbr1tm1Bopa/Tgfbr1+
Genetic Background: B6.Cg-Tgfbr1tm1Bopa ApcMin

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srrrgsc1872/Srrrgsc1872
Genetic Background: C57BL/6JJcl-Srrrgsc1872

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srrrgsc1872/Srrrgsc1872
Genetic Background: C57BL/6JJcl-Srrrgsc1872

Allelic Composition: Srrtm1.2Jtc/Srrtm1.2Jtc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srrrgsc1872/Srrrgsc1872
Genetic Background: C57BL/6JJcl-Srrrgsc1872

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srrrgsc1872/Srrrgsc1872
Genetic Background: C57BL/6JJcl-Srrrgsc1872

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001323 Srr / Q9QZX7 / Serine racemase / Q9GZT4*  / complex






 

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