ENSMUSG00000001436


Mus musculus

Features
Gene ID: ENSMUSG00000001436
  
Biological name :Slc19a1
  
Synonyms : P41438 / Slc19a1 / solute carrier family 19 (folate transporter), member 1
  
Possible biological names infered from orthology : P41440 / solute carrier family 19 member 1
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 77032241
Gene end: 77061002
  
Corresponding Affymetrix probe sets: 10364239 (MoGene1.0st)   1420138_at (Mouse Genome 430 2.0 Array)   1448132_at (Mouse Genome 430 2.0 Array)   1449744_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115658
Ensembl peptide - ENSMUSP00000121237
Ensembl peptide - ENSMUSP00000120266
Ensembl peptide - ENSMUSP00000119382
Ensembl peptide - ENSMUSP00000116784
Ensembl peptide - ENSMUSP00000116657
Ensembl peptide - ENSMUSP00000101050
Ensembl peptide - ENSMUSP00000114884
NCBI entrez gene - 20509     See in Manteia.
MGI - MGI:103182
RefSeq - XM_006513419
RefSeq - XM_006513417
RefSeq - XM_006513416
RefSeq - XM_006513415
RefSeq - XM_006513414
RefSeq - NM_031196
RefSeq - NM_001199271
RefSeq Peptide - NP_001186200
RefSeq Peptide - NP_112473
swissprot - D3Z4F3
swissprot - P41438
swissprot - Q542F3
swissprot - F6YWA3
swissprot - D3YU74
swissprot - D3YZE1
swissprot - D3Z0I6
swissprot - E9Q8X6
Ensembl - ENSMUSG00000001436
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc19a1ENSDARG00000033993Danio rerio
 SLC19A1ENSGALG00000030511Gallus gallus
 P41440ENSG00000173638Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99PL8 / Slc19a3 / Thiamine transporter 2 / Q9BZV2* / solute carrier family 19 member 3*ENSMUSG0000003849633
Q9EQN9 / Slc19a2 / Thiamine transporter 1 / O60779* / solute carrier family 19 member 2*ENSMUSG0000004091833


Protein motifs (from Interpro)
Interpro ID Name
 IPR002666  Reduced folate carrier
 IPR020846  Major facilitator superfamily domain
 IPR028339  Folate transporter 1
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015884 folic acid transport IEA
 biological_processGO:0035461 vitamin transmembrane transport IEA
 biological_processGO:0051180 vitamin transport IEA
 biological_processGO:0051958 methotrexate transport IEA
 biological_processGO:0098838 folate transmembrane transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0005542 folic acid binding IBA
 molecular_functionGO:0008517 folic acid transmembrane transporter activity IEA
 molecular_functionGO:0008518 folate:anion antiporter activity IEA
 molecular_functionGO:0015350 methotrexate transmembrane transporter activity IEA
 molecular_functionGO:0090482 vitamin transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Folr1tm1Fnn/Folr1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Folr1tm1Fnn/Folr1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Folr1tm1Fnn/Folr1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Folr1tm1Fnn/Folr1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Folr1tm1Fnn/Folr1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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