ENSMUSG00000038496


Mus musculus

Features
Gene ID: ENSMUSG00000038496
  
Biological name :Slc19a3
  
Synonyms : Q99PL8 / Slc19a3 / Thiamine transporter 2
  
Possible biological names infered from orthology : Q9BZV2 / solute carrier family 19 member 3
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C5
Gene start: 83012523
Gene end: 83038448
  
Corresponding Affymetrix probe sets: 10356145 (MoGene1.0st)   1436417_at (Mouse Genome 430 2.0 Array)   1450348_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041683
Ensembl peptide - ENSMUSP00000126646
NCBI entrez gene - 80721     See in Manteia.
MGI - MGI:1931307
RefSeq - XM_011238716
RefSeq - NM_030556
RefSeq - XM_006496580
RefSeq - XM_011238715
RefSeq - XM_006496579
RefSeq Peptide - NP_085033
swissprot - Q99PL8
Ensembl - ENSMUSG00000038496
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc19a3aENSDARG00000006447Danio rerio
 slc19a3bENSDARG00000061103Danio rerio
 ENSGALG00000021092Gallus gallus
 ENSGALG00000003025Gallus gallus
 Q9BZV2ENSG00000135917Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9EQN9 / Slc19a2 / Thiamine transporter 1 / O60779* / solute carrier family 19 member 2*ENSMUSG0000004091847
P41438 / Slc19a1 / solute carrier family 19 (folate transporter), member 1 / P41440* / solute carrier family 19 member 1*ENSMUSG0000000143635


Protein motifs (from Interpro)
Interpro ID Name
 IPR002666  Reduced folate carrier
 IPR020846  Major facilitator superfamily domain
 IPR028337  Thiamine transporter 2
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015888 thiamine transport ISO
 biological_processGO:0051180 vitamin transport IEA
 biological_processGO:0071934 thiamine transmembrane transport IMP
 cellular_componentGO:0005886 plasma membrane IC
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0015234 thiamine transmembrane transporter activity IMP
 molecular_functionGO:0090482 vitamin transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Vitamin B1 (thiamin) metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0001671 abnormal vitamin absorption "anomalous ability to take in any of a group of organic substances, present in food, that are essential to normal metabolism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0008986 abnormal liver parenchyma morphology "any structural anomaly of the functional units of the liver including the lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009860 nephrosclerosis "hardening of the kidney from overgrowth, infiltration by fibrous connective tissue, and contraction of the interstitial connective tissue; often a result of renovascular diseases or chronic hypertension" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C12.777.419.610]
Show

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011226 abnormal thiamin level "any anomaly in the concentration of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver" [GO:0006772]
Show

Allelic Composition: Rbpjtm1Hon/Rbpjtm1.1Hon,Shhtm2(cre/ERT2)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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