ENSMUSG00000001508


Mus musculus

Features
Gene ID: ENSMUSG00000001508
  
Biological name :Sgca
  
Synonyms : Alpha-sarcoglycan / P82350 / Sgca
  
Possible biological names infered from orthology : Q16586 / sarcoglycan alpha
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 94962791
Gene end: 94976327
  
Corresponding Affymetrix probe sets: 10390090 (MoGene1.0st)   1422654_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117637
Ensembl peptide - ENSMUSP00000118455
Ensembl peptide - ENSMUSP00000130617
Ensembl peptide - ENSMUSP00000099451
Ensembl peptide - ENSMUSP00000098118
NCBI entrez gene - 20391     See in Manteia.
MGI - MGI:894698
RefSeq - XM_017314395
RefSeq - NM_009161
RefSeq - XM_011248836
RefSeq Peptide - NP_033187
swissprot - Q5SWB0
swissprot - Q5SWB4
swissprot - P82350
Ensembl - ENSMUSG00000001508
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgcaENSDARG00000074156Danio rerio
 SGCAENSG00000108823Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sgce / O70258 / Epsilon-sarcoglycan / O43556* / sarcoglycan epsilon*ENSMUSG0000000463145


Protein motifs (from Interpro)
Interpro ID Name
 IPR006644  Dystroglycan-type cadherin-like
 IPR008908  Sarcoglycan alpha/epsilon
 IPR015919  Cadherin-like
 IPR028658  Alpha-sarcoglycan


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003012 muscle system process IBA
 biological_processGO:0014894 response to denervation involved in regulation of muscle adaptation IEA
 biological_processGO:0043403 skeletal muscle tissue regeneration IEA
 biological_processGO:0061024 membrane organization TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016011 dystroglycan complex IDA
 cellular_componentGO:0016012 sarcoglycan complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0045121 membrane raft IDA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Sgcatm2Kcam/Sgcatm2Kcam
Genetic Background: either: (129S6/SvEvTac-Sgcatm2Kcam) or (involves: 129S6/SvEvTac * C57BL/6J)

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Selenoptm1Rfb/Selenoptm1Rfb
Genetic Background: involves: 129 * C57BL/6J

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003199 muscle calcification "pathologic deposition of calcium salts in muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Sgcatm2Kcam/Sgcatm2Kcam
Genetic Background: either: (129S6/SvEvTac-Sgcatm2Kcam) or (involves: 129S6/SvEvTac * C57BL/6J)

 MP:0003397 increased muscle weight "greater than average muscle weight" [J:94134, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgcatm2Kcam/Sgcatm2Kcam
Genetic Background: either: (129S6/SvEvTac-Sgcatm2Kcam) or (involves: 129S6/SvEvTac * C57BL/6J)

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Sgcatm2Kcam/Sgcatm2Kcam
Genetic Background: either: (129S6/SvEvTac-Sgcatm2Kcam) or (involves: 129S6/SvEvTac * C57BL/6J)

 MP:0004121 abnormal sarcolemma morphology "structural anomaly in the plasma membrane of a muscle fiber that is cabable of conducting electrical impuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Sgcatm2Kcam/Sgcatm2Kcam
Genetic Background: either: (129S6/SvEvTac-Sgcatm2Kcam) or (involves: 129S6/SvEvTac * C57BL/6J)

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Tg(Ckm-SGCE)1Kcam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Sgcatm2Kcam/Sgcatm2Kcam
Genetic Background: either: (129S6/SvEvTac-Sgcatm2Kcam) or (involves: 129S6/SvEvTac * C57BL/6J)

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

 MP:0009423 increased extensor digitorum longus weight "increase in the weight of the penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

 MP:0009425 increased soleus weight "increase in the weight of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Sgcatm2Kcam/Sgcatm2Kcam
Genetic Background: either: (129S6/SvEvTac-Sgcatm2Kcam) or (involves: 129S6/SvEvTac * C57BL/6J)

 MP:0010106 abnormal circulating pyruvate kinase level "abnormal concentration in the blood of the phosphotransferase in the glycolytic pathway that catalyzes the transfer of phosphate from phosphoenolpyruvate to ADP, forming ATP and p; deficiency results in hemolytic anemia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

 MP:0010632 cardiac muscle necrosis "pathological death of cardiomyocytes or a portion of the cardiac muscle tissue; usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf8tm2Mrc/Fgf8tm2Mrc
Genetic Background: Not Specified

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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