ENSMUSG00000004631


Mus musculus

Features
Gene ID: ENSMUSG00000004631
  
Biological name :Sgce
  
Synonyms : Epsilon-sarcoglycan / O70258 / Sgce
  
Possible biological names infered from orthology : O43556 / sarcoglycan epsilon
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A1
Gene start: 4674350
Gene end: 4747207
  
Corresponding Affymetrix probe sets: 10542965 (MoGene1.0st)   1420688_a_at (Mouse Genome 430 2.0 Array)   1443518_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120910
Ensembl peptide - ENSMUSP00000120718
Ensembl peptide - ENSMUSP00000121964
Ensembl peptide - ENSMUSP00000004750
Ensembl peptide - ENSMUSP00000088185
Ensembl peptide - ENSMUSP00000099200
Ensembl peptide - ENSMUSP00000111240
Ensembl peptide - ENSMUSP00000111242
NCBI entrez gene - 20392     See in Manteia.
MGI - MGI:1329042
RefSeq - XM_006505024
RefSeq - NM_001130188
RefSeq - NM_001130189
RefSeq - NM_001130190
RefSeq - NM_001130191
RefSeq - NM_011360
RefSeq - XM_006505019
RefSeq - XM_006505020
RefSeq - XM_006505021
RefSeq - XM_006505022
RefSeq - XM_006505023
RefSeq Peptide - NP_001123662
RefSeq Peptide - NP_001123663
RefSeq Peptide - NP_035490
RefSeq Peptide - NP_001123661
RefSeq Peptide - NP_001123660
swissprot - E9PX46
swissprot - O70258
swissprot - D3Z572
swissprot - F6R6P2
swissprot - F6ULV5
swissprot - F6WKE4
swissprot - F8WGM3
Ensembl - ENSMUSG00000004631
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgceENSDARG00000012138Danio rerio
 SGCEENSGALG00000009670Gallus gallus
 SGCEENSG00000127990Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sgca / P82350 / Alpha-sarcoglycan / Q16586* / sarcoglycan alpha*ENSMUSG0000000150837


Protein motifs (from Interpro)
Interpro ID Name
 IPR006644  Dystroglycan-type cadherin-like
 IPR008908  Sarcoglycan alpha/epsilon
 IPR030775  Epsilon-sarcoglycan


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003012 muscle system process IBA
 biological_processGO:0061024 membrane organization IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016010 dystrophin-associated glycoprotein complex ISO
 cellular_componentGO:0016012 sarcoglycan complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032590 dendrite membrane IDA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rad54btm1Roka/Rad54btm1Roka
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Sgcetm1Ygl/Sgce+
Genetic Background: involves: 129S2/SvPas

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sgcetm1Ygl/Sgce+
Genetic Background: involves: 129S2/SvPas

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rad54btm1Roka/Rad54btm1Roka
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Sgcetm1Ygl/Sgce+
Genetic Background: involves: 129S2/SvPas

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Rad54btm1Roka/Rad54btm1Roka
Genetic Background: involves: 129P2/OlaHsd

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Sgcetm1Ygl/Sgce+
Genetic Background: involves: 129S2/SvPas

 MP:0003122 maternal imprinting "specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rad54btm1Roka/Rad54btm1Roka
Genetic Background: involves: 129P2/OlaHsd

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003908 decreased stereotypic behavior "less frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Sgcetm1Ygl/Sgce+
Genetic Background: involves: 129S2/SvPas

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010632 cardiac muscle necrosis "pathological death of cardiomyocytes or a portion of the cardiac muscle tissue; usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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