ENSMUSG00000001739


Mus musculus

Features
Gene ID: ENSMUSG00000001739
  
Biological name :Cldn15
  
Synonyms : Claudin-15 / Cldn15 / Q9Z0S5
  
Possible biological names infered from orthology : P56746
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 136966616
Gene end: 136975858
  
Corresponding Affymetrix probe sets: 10526514 (MoGene1.0st)   1418920_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001790
Ensembl peptide - ENSMUSP00000106722
NCBI entrez gene - 60363     See in Manteia.
MGI - MGI:1913103
RefSeq - NM_021719
RefSeq Peptide - NP_068365
swissprot - Q9Z0S5
Ensembl - ENSMUSG00000001739
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cldn15aENSDARG00000112049Danio rerio
 cldn15bENSDARG00000101109Danio rerio
 CLDN15ENSG00000106404Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cldn10 / Q9Z0S6 / Claudin-10 / P78369*ENSMUSG0000002213245
Cldn17 / Q8BXA6 / Claudin-17 / P56750*ENSMUSG0000005581130
Cldn18 / P56857 / Claudin-18 / P56856*ENSMUSG0000003247328
Cldn24 / claudin 24 / CLDN22* / A6NM45* / Q8N7P3* / claudin 22*ENSMUSG0000006197426
Q9D7U6 / Cldn22 / Claudin-22 / CLDN24* / A6NM45* / Q8N7P3* / claudin 24*ENSMUSG0000003806426
Cldn20 / claudin 20 / P56880*ENSMUSG0000009153023


Protein motifs (from Interpro)
Interpro ID Name
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR008094  Claudin-15
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000481 abnormal intestinal cell number "deviation from the normal numbers of enteryocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004002 abnormal jejunum morphology "malformation of the portion of the small intestine that extends from the duodenum to the ileum" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009483 enlarged ileum "increased size of the portion of the small intestine that extends from the jejunum to the colon" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011882 enlarged duodenum "increased size of the portion of the small intestine that extends from the pyloris to the junction with the jejunum" [MGI:Colin_McKerlie]
Show

Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0013796 abnormal duodenal goblet cell morphology "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the duodenum of the small intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus" [PMID:25872481]
Show

Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0013798 abnormal jeujunal goblet cell morphology "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the jejunum of the small intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus" [PMID:25872481]
Show

Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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