ENSMUSG00000032473


Mus musculus

Features
Gene ID: ENSMUSG00000032473
  
Biological name :Cldn18
  
Synonyms : Claudin-18 / Cldn18 / P56857
  
Possible biological names infered from orthology : P56856
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E3.3
Gene start: 99689461
Gene end: 99717267
  
Corresponding Affymetrix probe sets: 10596014 (MoGene1.0st)   1425445_a_at (Mouse Genome 430 2.0 Array)   1449428_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035048
Ensembl peptide - ENSMUSP00000108503
Ensembl peptide - ENSMUSP00000115782
Ensembl peptide - ENSMUSP00000117382
NCBI entrez gene - 56492     See in Manteia.
MGI - MGI:1929209
RefSeq - NM_001194922
RefSeq - NM_001194921
RefSeq - NM_001194923
RefSeq - NM_019815
RefSeq Peptide - NP_001181850
RefSeq Peptide - NP_001181851
RefSeq Peptide - NP_001181852
RefSeq Peptide - NP_062789
swissprot - P56857
Ensembl - ENSMUSG00000032473
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FQ377628.1ENSDARG00000103087Danio rerio
 CLDN18ENSGALG00000006593Gallus gallus
 CLDN18ENSG00000066405Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cldn10 / Q9Z0S6 / Claudin-10 / P78369*ENSMUSG0000002213227
Cldn24 / claudin 24 / CLDN22* / A6NM45* / Q8N7P3* / claudin 22*ENSMUSG0000006197426
Cldn20 / claudin 20 / P56880*ENSMUSG0000009153025
Q9D7U6 / Cldn22 / Claudin-22 / CLDN24* / A6NM45* / Q8N7P3* / claudin 24*ENSMUSG0000003806425
Cldn17 / Q8BXA6 / Claudin-17 / P56750*ENSMUSG0000005581125
Cldn15 / Q9Z0S5 / Claudin-15 / P56746*ENSMUSG0000000173924


Protein motifs (from Interpro)
Interpro ID Name
 IPR003928  Claudin-18
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045779 negative regulation of bone resorption IMP
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0071847 TNFSF11-mediated signaling pathway IMP
 biological_processGO:1900181 negative regulation of protein localization to nucleus IDA
 biological_processGO:2001205 negative regulation of osteoclast development IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004140 abnormal chief cell morphology "malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010810 increased type II pneumocyte number "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
Show

Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010898 abnormal pulmonary alveolus epithelium morphology "any structural anomaly of the epithelial layer of the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0010899 abnormal pulmonary alveolar system morphology 
Show

Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0010933 decreased trabecular bone connectivity density "reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]
Show

Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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