ENSG00000066405


Homo sapiens

Features
Gene ID: ENSG00000066405
  
Biological name :CLDN18
  
Synonyms : claudin 18 / CLDN18 / P56856
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q22.3
Gene start: 137998735
Gene end: 138033655
  
Corresponding Affymetrix probe sets: 214135_at (Human Genome U133 Plus 2.0 Array)   221132_at (Human Genome U133 Plus 2.0 Array)   221133_s_at (Human Genome U133 Plus 2.0 Array)   232578_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000340939
Ensembl peptide - ENSP00000183605
Ensembl peptide - ENSP00000419732
NCBI entrez gene - 51208     See in Manteia.
OMIM - 609210
RefSeq - NM_016369
RefSeq - NM_001002026
RefSeq Peptide - NP_001002026
RefSeq Peptide - NP_057453
swissprot - P56856
swissprot - F8WEY4
Ensembl - ENSG00000066405
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FQ377628.1ENSDARG00000103087Danio rerio
 CLDN18ENSGALG00000006593Gallus gallus
 Cldn18ENSMUSG00000032473Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLDN10 / P78369 / claudin 10ENSG0000013487328
CLDN22 / Q8N7P3 / claudin 22ENSG0000017730026
A6NM45 / CLDN24 / claudin 24ENSG0000018575826
CLDN17 / P56750 / claudin 17ENSG0000015628225
CLDN15 / P56746 / claudin 15ENSG0000010640425
CLDN20 / P56880 / claudin 20ENSG0000017121723
C9JDP6 / CLDN25 / claudin 25ENSG0000022860720


Protein motifs (from Interpro)
Interpro ID Name
 IPR003928  Claudin-18
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045779 negative regulation of bone resorption IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0071847 TNFSF11-mediated signaling pathway IEA
 biological_processGO:1900181 negative regulation of protein localization to nucleus IEA
 biological_processGO:2001205 negative regulation of osteoclast development IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
Tight junction interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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