ENSMUSG00000022132


Mus musculus

Features
Gene ID: ENSMUSG00000022132
  
Biological name :Cldn10
  
Synonyms : Claudin-10 / Cldn10 / Q9Z0S6
  
Possible biological names infered from orthology : P78369
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: E4
Gene start: 118787908
Gene end: 118875489
  
Corresponding Affymetrix probe sets: 10417027 (MoGene1.0st)   10422312 (MoGene1.0st)   1426147_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071476
Ensembl peptide - ENSMUSP00000097889
Ensembl peptide - ENSMUSP00000041616
NCBI entrez gene - 58187     See in Manteia.
MGI - MGI:1913101
RefSeq - NM_023878
RefSeq - NM_021386
RefSeq - NM_001160096
RefSeq - NM_001160097
RefSeq - NM_001160098
RefSeq - NM_001160099
RefSeq Peptide - NP_001153568
RefSeq Peptide - NP_001153569
RefSeq Peptide - NP_001153570
RefSeq Peptide - NP_001153571
RefSeq Peptide - NP_067361
RefSeq Peptide - NP_076367
swissprot - Q9Z0S6
Ensembl - ENSMUSG00000022132
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cldn10aENSDARG00000058937Danio rerio
 cldn10bENSDARG00000104528Danio rerio
 CLDN10ENSGALG00000019114Gallus gallus
 CLDN10ENSG00000134873Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cldn15 / Q9Z0S5 / Claudin-15 / P56746*ENSMUSG0000000173944
Cldn17 / Q8BXA6 / Claudin-17 / P56750*ENSMUSG0000005581131
Cldn18 / P56857 / Claudin-18 / P56856*ENSMUSG0000003247331
Cldn20 / claudin 20 / P56880*ENSMUSG0000009153028
Cldn24 / claudin 24 / CLDN22* / A6NM45* / Q8N7P3* / claudin 22*ENSMUSG0000006197424
Q9D7U6 / Cldn22 / Claudin-22 / CLDN24* / A6NM45* / Q8N7P3* / claudin 24*ENSMUSG0000003806424


Protein motifs (from Interpro)
Interpro ID Name
 IPR003554  Claudin-10
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
 biological_processGO:0043269 regulation of ion transport IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0002986 hypocalciuria "excretion of abnormally low amounts of calcium in the urine" [J:83000]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0003197 kidney calcification "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0006357 abnormal circulating mineral level "anomalous concentration in the blood of any naturally occurring, homogeneous inorganic solid substance having a definite chemical composition and highly ordered atomic arrangement that is required for growth and survival" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0009350 decreased urine pH "increased urine acidity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0010092 increased circulating magnesium level "an elevation in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0010107 abnormal renal reabsorption "any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0010111 abnormal renal calcium reabsorption "any anomaly in the process by which calcium ions are transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0011436 decreased urine magnesium level "lower than normal amount of magnesium in the urine" [MGI:anna]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0011467 decreased urine urea nitrogen level "abnormally low amounts of nitrogen in the form of urea in the urine" [MGI:csmith]
Show

Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr