ENSMUSG00000001773


Mus musculus

Features
Gene ID: ENSMUSG00000001773
  
Biological name :Folh1
  
Synonyms : Folh1 / Glutamate carboxypeptidase 2 / O35409
  
Possible biological names infered from orthology : folate hydrolase 1 / Q04609
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D3
Gene start: 86718977
Gene end: 86775943
  
Corresponding Affymetrix probe sets: 10565401 (MoGene1.0st)   1450154_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001824
Ensembl peptide - ENSMUSP00000102892
NCBI entrez gene - 53320     See in Manteia.
MGI - MGI:1858193
RefSeq - XM_006508023
RefSeq - NM_001159706
RefSeq - NM_016770
RefSeq Peptide - NP_058050
RefSeq Peptide - NP_001153178
swissprot - O35409
swissprot - Q0VDM6
Ensembl - ENSMUSG00000001773
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 naalad2ENSDARG00000021383Danio rerio
 FOLH1ENSGALG00000017234Gallus gallus
 FOLH1ENSG00000086205Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9CZR2 / Naalad2 / N-acetylated alpha-linked acidic dipeptidase 2 / Q9Y3Q0*ENSMUSG0000004394365
Q7M758 / Naaladl1 / N-acetylated-alpha-linked acidic dipeptidase-like protein / Q9UQQ1* / N-acetylated alpha-linked acidic dipeptidase like 1*ENSMUSG0000005499937
Tfrc / Q62351 / transferrin receptor / P02786*ENSMUSG0000002279725
Tfr2 / Q9JKX3 / Transferrin receptor protein 2 / Q9UP52* / transferrin receptor 2*ENSMUSG0000002971625
Naaladl2 / N-acetylated alpha-linked acidic dipeptidase like 2 / Q58DX5*ENSMUSG0000010275822


Protein motifs (from Interpro)
Interpro ID Name
 IPR003137  PA domain
 IPR007365  Transferrin receptor-like, dimerisation domain
 IPR007484  Peptidase M28
 IPR036757  Transferrin receptor-like, dimerisation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0006760 folic acid-containing compound metabolic process IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0035609 C-terminal protein deglutamylation IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004180 carboxypeptidase activity IDA
 molecular_functionGO:0004181 metallocarboxypeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016805 dipeptidase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1904492 Ac-Asp-Glu binding IEA
 molecular_functionGO:1904493 tetrahydrofolyl-poly(glutamate) polymer binding IEA


Pathways (from Reactome)
Pathway description
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr3tm4.1Cxd/Fgfr3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
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Allelic Composition: Dbn1tm1.1Lbc/Dbn1+
Genetic Background: B6.Cg-Dbn1tm1.1Lbc

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Fgfr3tm4.1Cxd/Fgfr3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr3tm4.1Cxd/Fgfr3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr3tm4.1Cxd/Fgfr3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dbn1tm1.1Lbc/Dbn1+
Genetic Background: B6.Cg-Dbn1tm1.1Lbc

 MP:0004220 abnormal peripheral nervous system regeneration "changes in the ability or inability of healthy peripheral nervous system tissue to regenerate following injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr3tm4.1Cxd/Fgfr3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbn1tm1.1Lbc/Dbn1+
Genetic Background: B6.Cg-Dbn1tm1.1Lbc

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Fgfr3tm4.1Cxd/Fgfr3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr3tm4.1Cxd/Fgfr3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr3tm4.1Cxd/Fgfr3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr3tm4.1Cxd/Fgfr3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Fgfr3tm4.1Cxd/Fgfr3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0012066 decreased astrocyte number "reduction in the number of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord" [CL:0000127, MGI:csmith]
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Allelic Composition: Dbn1tm1.1Lbc/Dbn1+
Genetic Background: B6.Cg-Dbn1tm1.1Lbc

 MP:0012306 enhanced spatial learning "enhanced ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Dbn1tm1.1Lbc/Dbn1+
Genetic Background: B6.Cg-Dbn1tm1.1Lbc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001773 Folh1 / O35409 / Glutamate carboxypeptidase 2 / Q04609* / folate hydrolase 1*  / complex






 

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