ENSG00000086205


Homo sapiens

Features
Gene ID: ENSG00000086205
  
Biological name :FOLH1
  
Synonyms : folate hydrolase 1 / FOLH1 / Q04609
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p11.12
Gene start: 49146635
Gene end: 49208670
  
Corresponding Affymetrix probe sets: 205860_x_at (Human Genome U133 Plus 2.0 Array)   211303_x_at (Human Genome U133 Plus 2.0 Array)   215363_x_at (Human Genome U133 Plus 2.0 Array)   217483_at (Human Genome U133 Plus 2.0 Array)   217487_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431263
Ensembl peptide - ENSP00000349129
Ensembl peptide - ENSP00000431463
Ensembl peptide - ENSP00000436569
Ensembl peptide - ENSP00000434928
Ensembl peptide - ENSP00000431577
Ensembl peptide - ENSP00000256999
Ensembl peptide - ENSP00000344131
NCBI entrez gene - 2346     See in Manteia.
OMIM - 600934
RefSeq - XM_017017451
RefSeq - XM_017017441
RefSeq - XM_017017442
RefSeq - XM_017017443
RefSeq - XM_017017444
RefSeq - XM_017017445
RefSeq - XM_017017446
RefSeq - XM_017017447
RefSeq - XM_017017448
RefSeq - XM_017017449
RefSeq - XM_017017450
RefSeq - NM_001014986
RefSeq - NM_001193471
RefSeq - NM_001193472
RefSeq - NM_001193473
RefSeq - NM_004476
RefSeq - XM_011519958
RefSeq - XM_017017432
RefSeq - XM_017017433
RefSeq - XM_017017434
RefSeq - XM_017017435
RefSeq - XM_017017436
RefSeq - XM_017017437
RefSeq - XM_017017438
RefSeq - XM_017017439
RefSeq - XM_017017440
RefSeq Peptide - NP_001180400
RefSeq Peptide - NP_001180401
RefSeq Peptide - NP_001180402
RefSeq Peptide - NP_004467
RefSeq Peptide - NP_001014986
swissprot - E9PMK6
swissprot - E9PLV0
swissprot - E9PKM3
swissprot - Q04609
swissprot - E9PI29
Ensembl - ENSG00000086205
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 naalad2ENSDARG00000021383Danio rerio
 FOLH1ENSGALG00000017234Gallus gallus
 Folh1ENSMUSG00000001773Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Y3Q0 / NAALAD2 / N-acetylated alpha-linked acidic dipeptidase 2ENSG0000007761668
Q9UQQ1 / NAALADL1 / N-acetylated alpha-linked acidic dipeptidase like 1ENSG0000016806038
TFR2 / Q9UP52 / transferrin receptor 2ENSG0000010632725
TFRC / P02786 / transferrin receptorENSG0000007227424
Q58DX5 / NAALADL2 / N-acetylated alpha-linked acidic dipeptidase like 2ENSG0000017769422


Protein motifs (from Interpro)
Interpro ID Name
 IPR003137  PA domain
 IPR007365  Transferrin receptor-like, dimerisation domain
 IPR007484  Peptidase M28
 IPR036757  Transferrin receptor-like, dimerisation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0006760 folic acid-containing compound metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008652 cellular amino acid biosynthetic process TAS
 biological_processGO:0035609 C-terminal protein deglutamylation IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004180 carboxypeptidase activity IEA
 molecular_functionGO:0004181 metallocarboxypeptidase activity IDA
 molecular_functionGO:0008233 peptidase activity NAS
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016805 dipeptidase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1904492 Ac-Asp-Glu binding IDA
 molecular_functionGO:1904493 tetrahydrofolyl-poly(glutamate) polymer binding IDA


Pathways (from Reactome)
Pathway description
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000086205 FOLH1 / Q04609 / folate hydrolase 1  / complex






 

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contact: otassy@igbmc.fr