ENSMUSG00000001910


Mus musculus

Features
Gene ID: ENSMUSG00000001910
  
Biological name :Nacc1
  
Synonyms : Nacc1 / Nucleus accumbens-associated protein 1 / Q7TSZ8
  
Possible biological names infered from orthology : nucleus accumbens associated 1 / Q96RE7
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C2
Gene start: 84670483
Gene end: 84687862
  
Corresponding Affymetrix probe sets: 10542892 (MoGene1.0st)   10580188 (MoGene1.0st)   1420968_at (Mouse Genome 430 2.0 Array)   1420969_at (Mouse Genome 430 2.0 Array)   1433140_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001975
NCBI entrez gene - 66830     See in Manteia.
MGI - MGI:1914080
RefSeq - XM_006531295
RefSeq - NM_025788
RefSeq - XM_006531293
RefSeq - XM_006531294
RefSeq - XM_006531292
RefSeq Peptide - NP_080064
swissprot - Q7TSZ8
Ensembl - ENSMUSG00000001910
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nacc1aENSDARG00000099164Danio rerio
 nacc1bENSDARG00000078238Danio rerio
 NACC1ENSG00000160877Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nacc2 / Q9DCM7 / Nucleus accumbens-associated protein 2 / Q96BF6* / NACC family member 2*ENSMUSG0000002693256
Q9Z0G7 / Zbtb22 / zinc finger and BTB domain containing 22 / O15209*ENSMUSG0000005139018
Zbtb37 / zinc finger and BTB domain containing 37 / Q5TC79*ENSMUSG0000004346717
Q9DAI4 / Zbtb43 / zinc finger and BTB domain containing 43 / O43298*ENSMUSG0000002678816
Q8K0L9 / Zbtb20 / zinc finger and BTB domain containing 20 / Q9HC78*ENSMUSG0000002270815
Zbtb9 / Q8CDC7 / zinc finger and BTB domain containing 9 / Q96C00*ENSMUSG0000007960515
Zbtb34 / zinc finger and BTB domain containing 34 / Q8NCN2*ENSMUSG0000006896614
Q52KG4 / Zbtb45 / zinc finger and BTB domain containing 45 / Q96K62*ENSMUSG0000004960013
Zbtb6 / Q8K088 / zinc finger and BTB domain containing 6 / Q15916*ENSMUSG0000006679812
Zbtb26 / zinc finger and BTB domain containing 26 / Q9HCK0*ENSMUSG0000005071412
Zbtb12 / zinc finger and BTB domain containing 12 / Q9Y330*ENSMUSG0000004982311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR018379  BEN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0051260 protein homooligomerization IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atf3tm1Dron/Atf3tm1Dron,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000461 reduced number of presacral vertebrae "redecued number of the vertebrae anterior to the sacrum" [J:13069]
Show

Allelic Composition: Atf3tm1Dron/Atf3tm1Dron,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Atf3tm1Dron/Atf3tm1Dron,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Atf3tm1Dron/Atf3tm1Dron,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atf3tm1Dron/Atf3tm1Dron,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atf3tm1Dron/Atf3tm1Dron,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Atf3tm1Dron/Atf3tm1Dron,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atf3tm1Dron/Atf3tm1Dron,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004622 sacral vertebral fusion "the union of one or more sacral vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atf3tm1Dron/Atf3tm1Dron,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Isl2tm3.1(Mnx1-Lhx3)Slp/Isl2+,Tg(Mnx1-GFP)1Slp/?
Genetic Background: Not Specified

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Isl2tm3.1(Mnx1-Lhx3)Slp/Isl2+,Tg(Mnx1-GFP)1Slp/?
Genetic Background: Not Specified

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Isl2tm3.1(Mnx1-Lhx3)Slp/Isl2+,Tg(Mnx1-GFP)1Slp/?
Genetic Background: Not Specified

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Atf3tm1Dron/Atf3tm1Dron,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Nacc1tm1.1Jlwa/Nacc1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Atf3tm1Dron/Atf3tm1Dron,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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