Manteia

ENSMUSG00000022708

Mus musculus

Features

Gene ID:	ENSMUSG00000022708

Biological name :	Zbtb20

Synonyms :	Q8K0L9 / Zbtb20 / zinc finger and BTB domain containing 20

Possible biological names infered from orthology :	Q9HC78

Species:	Mus musculus

Chr. number:	16
Strand:	1
Band:	B4
Gene start:	42875881
Gene end:	43642602

Corresponding Affymetrix probe sets:	10435769 (MoGene1.0st) 10435789 (MoGene1.0st) 10435791 (MoGene1.0st) 1422064_a_at (Mouse Genome 430 2.0 Array) 1437065_at (Mouse Genome 430 2.0 Array) 1437066_at (Mouse Genome 430 2.0 Array) 1437598_at (Mouse Genome 430 2.0 Array) 1438443_at (Mouse Genome 430 2.0 Array) 1439128_at (Mouse Genome 430 2.0 Array) 1439278_at (Mouse Genome 430 2.0 Array) 1443471_at (Mouse Genome 430 2.0 Array) 1451577_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000124798 Ensembl peptide - ENSMUSP00000124189 Ensembl peptide - ENSMUSP00000124984 Ensembl peptide - ENSMUSP00000125241 Ensembl peptide - ENSMUSP00000125233 Ensembl peptide - ENSMUSP00000125016 Ensembl peptide - ENSMUSP00000078410 Ensembl peptide - ENSMUSP00000110338 Ensembl peptide - ENSMUSP00000110339 Ensembl peptide - ENSMUSP00000110342 Ensembl peptide - ENSMUSP00000110343 Ensembl peptide - ENSMUSP00000124126 NCBI entrez gene - 56490 See in Manteia. MGI - MGI:1929213 RefSeq - XM_017317105 RefSeq - XM_017317096 RefSeq - XM_017317097 RefSeq - XM_017317098 RefSeq - XM_017317099 RefSeq - XM_017317100 RefSeq - XM_017317101 RefSeq - XM_017317102 RefSeq - XM_017317103 RefSeq - XM_017317104 RefSeq - NM_001285805 RefSeq - NM_019778 RefSeq - NM_181058 RefSeq - XM_006522403 RefSeq - XM_006522404 RefSeq - XM_006522406 RefSeq - XM_006522409 RefSeq - XM_006522411 RefSeq - XM_006522412 RefSeq - XM_006522413 RefSeq - XM_006522414 RefSeq - XM_006522415 RefSeq - XM_006522416 RefSeq - XM_006522418 RefSeq - XM_006522422 RefSeq - XM_006522424 RefSeq - XM_011245978 RefSeq - XM_011245979 RefSeq - XM_011245980 RefSeq - XM_011245981 RefSeq - XM_011245982 RefSeq - XM_011245983 RefSeq - XM_011245984 RefSeq - XM_011245985 RefSeq - XM_011245986 RefSeq - XM_011245987 RefSeq - XM_011245988 RefSeq - XM_011245989 RefSeq - XM_011245990 RefSeq - XM_017317087 RefSeq - XM_017317088 RefSeq - XM_017317089 RefSeq - XM_017317090 RefSeq - XM_017317091 RefSeq - XM_017317092 RefSeq - XM_017317093 RefSeq - XM_017317094 RefSeq - XM_017317095 RefSeq Peptide - NP_062752 RefSeq Peptide - NP_851401 RefSeq Peptide - NP_001272734 swissprot - E0CXK1 swissprot - E0CYJ9 swissprot - Q8K0L9 swissprot - E0CX28 swissprot - E0CYH3 swissprot - E0CXT9 Ensembl - ENSMUSG00000022708

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
zbtb20	ENSDARG00000005586	Danio rerio
ZBTB20	ENSGALG00000015094	Gallus gallus
Q9HC78	ENSG00000181722	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q52KG4 / Zbtb45 / zinc finger and BTB domain containing 45 / Q96K62*	ENSMUSG00000049600	29
Q9Z0G7 / Zbtb22 / zinc finger and BTB domain containing 22 / O15209*	ENSMUSG00000051390	16
Zbtb9 / Q8CDC7 / zinc finger and BTB domain containing 9 / Q96C00*	ENSMUSG00000079605	15
Zbtb26 / zinc finger and BTB domain containing 26 / Q9HCK0*	ENSMUSG00000050714	13
Zbtb34 / zinc finger and BTB domain containing 34 / Q8NCN2*	ENSMUSG00000068966	13
Zbtb37 / zinc finger and BTB domain containing 37 / Q5TC79*	ENSMUSG00000043467	13
Q9DAI4 / Zbtb43 / zinc finger and BTB domain containing 43 / O43298*	ENSMUSG00000026788	13
Zbtb12 / zinc finger and BTB domain containing 12 / Q9Y330*	ENSMUSG00000049823	11
Nacc2 / Q9DCM7 / Nucleus accumbens-associated protein 2 / Q96BF6* / NACC family member 2*	ENSMUSG00000026932	11
Zbtb6 / Q8K088 / zinc finger and BTB domain containing 6 / Q15916*	ENSMUSG00000066798	11
Nacc1 / Q7TSZ8 / Nucleus accumbens-associated protein 1 / Q96RE7* / nucleus accumbens associated 1*	ENSMUSG00000001910	11

Protein motifs (from Interpro)

Interpro ID	Name
IPR000210	BTB/POZ domain
IPR011333	SKP1/BTB/POZ domain superfamily
IPR013087	Zinc finger C2H2-type
IPR036236	Zinc finger C2H2 superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0010629	negative regulation of gene expression	IMP
biological_process	GO:0032728	positive regulation of interferon-beta production	IMP
biological_process	GO:0032755	positive regulation of interleukin-6 production	IMP
biological_process	GO:0032760	positive regulation of tumor necrosis factor production	IMP
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	IDA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0016604	nuclear body	ISO
molecular_function	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003677	DNA binding	IDA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000808	abnormal hippocampus development	"improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000812	abnormal dentate gyrus morphology	"absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]	Show Allelic Composition: Zbtb20^tm1Stoy/Zbtb20^tm1Stoy Genetic Background: involves: 129S2/SvPas
MP:0000815	abnormal ammon gyrus morphology	"malformations of one of the two interlocking gyri of the hippocampus; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Zbtb20^tm1Stoy/Zbtb20^tm1Stoy Genetic Background: involves: 129S2/SvPas
MP:0001038	abnormal cholinergic neuron morphology	"malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter " [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Tg(Gfap-TGFB1)64Lms/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: BALB/c * C57BL/6 * DBA/2 * SJL
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Zbtb20^tm1Stoy/Zbtb20^tm1Stoy Genetic Background: involves: 129S2/SvPas
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Tbp^tm1.1Xjl/Tbp⁺ Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
MP:0001364	decreased anxiety-related response	"when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]	Show Allelic Composition: Gata2^tm1.1Sac/Gata2^tm1.1Sac Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Pla2g4a^tm1Jvb/Pla2g4a⁺,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Pla2g4a^tm1Jvb/Pla2g4a^tm1Jvb,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Gata2^tm1.1Sac/Gata2^tm1.1Sac Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Zbtb20^tm1Stoy/Zbtb20^tm1Stoy Genetic Background: involves: 129S2/SvPas
MP:0001463	abnormal spatial learning	"defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Gata2^tm1.1Sac/Gata2^tm1.1Sac Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Mapt^tm1Hnd/Mapt⁺,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Pla2g4a^tm1Jvb/Pla2g4a⁺,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Pla2g4a^tm1Jvb/Pla2g4a^tm1Jvb,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Tg(Gfap-TGFB1)64Lms/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: BALB/c * C57BL/6 * DBA/2 * SJL
MP:0001511	disheveled coat	"coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zbtb20^tm1Stoy/Zbtb20^tm1Stoy Genetic Background: involves: 129S2/SvPas
MP:0001614	abnormal vasculature	"anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tg(Gfap-TGFB1)64Lms/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: BALB/c * C57BL/6 * DBA/2 * SJL
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001908	abnormal somatosensory cortex function	"anomalous activity of the area of the parietal lobe concerned with receiving general sensations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tg(Gfap-TGFB1)64Lms/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: BALB/c * C57BL/6 * DBA/2 * SJL
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gata2^tm1.1Sac/Gata2^tm1.1Sac Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tg(Camk2a-IDE)1Selk/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Tg(Camk2a-MME)3Selk/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Zbtb20^tm1Stoy/Zbtb20^tm1Stoy Genetic Background: involves: 129S2/SvPas Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0,Tg(tetO-MAPT)32Lms/0 Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2
MP:0002183	gliosis	"increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tg(Camk2a-IDE)1Selk/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Tg(Camk2a-MME)3Selk/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0002229	CNS neurodegeneration	"a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gata2^tm1.1Sac/Gata2^tm1.1Sac Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002575	increased circulating ketone body level	"greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002712	increased circulating glucagon level	"greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002801	abnormal long-term recognition memory	"defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Gata2^tm1.1Sac/Gata2^tm1.1Sac Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002882	abnormal neuron	"anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Gata2^tm1.1Sac/Gata2^tm1.1Sac Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Mapt^tm1Hnd/Mapt^tm1Hnd,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Mapt^tm1Hnd/Mapt⁺,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
MP:0002887	resistance to pharmacologically induced seizures	"ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]	Show Allelic Composition: Mapt^tm1Hnd/Mapt^tm1Hnd,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Mapt^tm1Hnd/Mapt⁺,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002906	susceptibility to pharmacologically induced seizures	"inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]	Show Allelic Composition: Gata2^tm1.1Sac/Gata2^tm1.1Sac Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0003240	loss of hippocampal neurons	"loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]	Show Allelic Composition: Zc3h12a^tm1Fum/Zc3h12a^tm1Fum Genetic Background: C57BL/6-Zc3h12a^tm1Fum
MP:0003329	amyloid beta deposits		Show Allelic Composition: Gata2^tm1.1Sac/Gata2^tm1.1Sac Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Mapt^tm1Hnd/Mapt^tm1Hnd,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Mapt^tm1Hnd/Mapt⁺,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Tg(Camk2a-IDE)1Selk/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Tg(Camk2a-MME)3Selk/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: B6.Cg-Zbtb20^{Tg(PDGFB-APPSwInd)20Lms} Allelic Composition: Tg(Gfap-TGFB1)64Lms/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: BALB/c * C57BL/6 * DBA/2 * SJL Allelic Composition: C3^tm1Crr/C3^tm1Crr,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/? Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Apoe^tm1Unc/Apoe^{tm2(APOE_i3)Yhg},Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Apoe^tm1Unc/Apoe^{tm3(APOE_i4)Yhg},Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Psen1^tm4.1Shn/Psen1⁺,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tg(Camk2a-IDE)1Selk/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Tg(Camk2a-MME)3Selk/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Tg(Gfap-TGFB1)64Lms/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: BALB/c * C57BL/6 * DBA/2 * SJL
MP:0004254	cerebral amyloid angiopathy	"a pathological condition where there is a deposition of amyloid in the walls of the small cerebral vessels which supply the brain; this results in an increased risk of infarcts and/or intracerebral hemorrhage, possibly resulting in dementia" [acv:Alicia Valenzuela_Genetic Resources Curator]	Show Allelic Composition: Tg(Gfap-TGFB1)64Lms/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: BALB/c * C57BL/6 * DBA/2 * SJL
MP:0004950	abnormal brain vasculature	"any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tg(Gfap-TGFB1)64Lms/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: BALB/c * C57BL/6 * DBA/2 * SJL
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0005343	increased circulating aspartate transaminase level	"greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0005344	increased circulating bilirubin level	"greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0005438	abnormal glycogen homeostasis	"abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0005439	decreased glycogen level	"less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0005591	decreased vasodilation	"less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tg(Gfap-TGFB1)64Lms/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: BALB/c * C57BL/6 * DBA/2 * SJL
MP:0005627	increased circulating potassium level	"greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0005668	decreased circulating leptin level	"less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0006203	eye hemorrhage	"bleeding into the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Zbtb20^tm1Stoy/Zbtb20^tm1Stoy Genetic Background: involves: 129S2/SvPas
MP:0008263	abnormal hippocampus CA1 region morphology		Show Allelic Composition: Zbtb20^tm1Stoy/Zbtb20^tm1Stoy Genetic Background: involves: 129S2/SvPas
MP:0008283	small hippocampus	"reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zbtb20^tm1Stoy/Zbtb20^tm1Stoy Genetic Background: involves: 129S2/SvPas
MP:0008287	abnormal subiculum morphology	"any structural anomaly of the transitional zone beteween the parahippocampal gyrus and the Ammon gyrus" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zbtb20^tm1Stoy/Zbtb20^tm1Stoy Genetic Background: involves: 129S2/SvPas
MP:0008414	abnormal spatial reference memory	"anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tg(Gfap-TGFB1)64Lms/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: BALB/c * C57BL/6 * DBA/2 * SJL
MP:0008415	abnormal neurite morphology	"any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]	Show Allelic Composition: Tg(Camk2a-IDE)1Selk/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Tg(Camk2a-MME)3Selk/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: B6.Cg-Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}
MP:0008569	lethality at weaning	"premature death at weaning age usually due to the inability to make the transition to solid food" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ace2^tm1Lex/Y Genetic Background: B6;129S5-Ace2^tm1Lex/Mmucd
MP:0009026	abnormal brain pia mater morphology	"any structural anomaly of the fibrous membrane forming the innermost of the three coverings that surrounds the brain within the cranial cavity that is firmly attached to the glial capsule" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Tg(Gfap-TGFB1)64Lms/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: BALB/c * C57BL/6 * DBA/2 * SJL
MP:0009642	abnormal blood homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gata2^tm1.1Sac/Gata2^tm1.1Sac Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Mapt^tm1Hnd/Mapt^tm1Hnd,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Mapt^tm1Hnd/Mapt⁺,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
MP:0009969	abnormal cerebral cortex pyramidal cell morphology	"any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0 Genetic Background: B6.Cg-Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}
MP:0010831	partial lethality	"the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tg(Camk2a-tTA)1Mmay/0,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0,Tg(tetO-MAPT)32Lms/0 Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2
MP:0011084	partial lethality at weaning	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]	Show Allelic Composition: Zbtb20^tm1.1Wpjz/Zbtb20^tm1.1Wpjz Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Zbtb20^tm1Stoy/Zbtb20^tm1Stoy Genetic Background: involves: 129S2/SvPas
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ace2^tm1Lex/Y Genetic Background: B6;129S5-Ace2^tm1Lex/Mmucd
MP:0012460	decreased dentate gyrus size	"reduced size of one of two interlocking gyri of the hippocampus formation that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [MGI:csmith]	Show Allelic Composition: Zbtb20^tm1Stoy/Zbtb20^tm1Stoy Genetic Background: involves: 129S2/SvPas
MP:0020448	increased microglial cell activation	"increase in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]	Show Allelic Composition: C3^tm1Crr/C3^tm1Crr,Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/? Genetic Background: involves: 129S4/SvJae * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr