ENSMUSG00000002455


Mus musculus

Features
Gene ID: ENSMUSG00000002455
  
Biological name :Prpf6
  
Synonyms : Pre-mRNA-processing factor 6 / Prpf6 / Q91YR7
  
Possible biological names infered from orthology : O94906
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H4
Gene start: 181591868
Gene end: 181655660
  
Corresponding Affymetrix probe sets: 10479649 (MoGene1.0st)   1424036_at (Mouse Genome 430 2.0 Array)   1426026_at (Mouse Genome 430 2.0 Array)   1454789_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117711
Ensembl peptide - ENSMUSP00000121340
Ensembl peptide - ENSMUSP00000002529
NCBI entrez gene - 68879     See in Manteia.
MGI - MGI:1922946
RefSeq - NM_133701
RefSeq Peptide - NP_598462
swissprot - B7ZCS1
swissprot - Q91YR7
Ensembl - ENSMUSG00000002455
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prpf6ENSDARG00000091367Danio rerio
 PRPF6ENSGALG00000006001Gallus gallus
 PRPF6ENSG00000101161Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003107  HAT (Half-A-TPR) repeat
 IPR010491  PRP1 splicing factor, N-terminal
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR027108  Pre-mRNA-processing factor 6/Prp1/STA1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000244 spliceosomal tri-snRNP complex assembly IEA
 biological_processGO:0000398 mRNA splicing, via spliceosome IEA
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006403 RNA localization IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005682 U5 snRNP IEA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0046540 U4/U6 x U5 tri-snRNP complex IEA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA
 molecular_functionGO:0050681 androgen receptor binding IEA


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prpf31tm1a(EUCOMM)Wtsi/Prpf31tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Prpf31tm1a(EUCOMM)Wtsi/Nju

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Prpf31tm1a(EUCOMM)Wtsi/Prpf31tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Prpf31tm1a(EUCOMM)Wtsi/Nju

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Prpf31tm1a(EUCOMM)Wtsi/Prpf31tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Prpf31tm1a(EUCOMM)Wtsi/Nju

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prpf31tm1a(EUCOMM)Wtsi/Prpf31tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Prpf31tm1a(EUCOMM)Wtsi/Nju

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prpf31tm1a(EUCOMM)Wtsi/Prpf31tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Prpf31tm1a(EUCOMM)Wtsi/Nju

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prpf31tm1a(EUCOMM)Wtsi/Prpf31tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Prpf31tm1a(EUCOMM)Wtsi/Nju

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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