ENSMUSG00000002588


Mus musculus

Features
Gene ID: ENSMUSG00000002588
  
Biological name :Pon1
  
Synonyms : P52430 / paraoxonase 1 / Pon1
  
Possible biological names infered from orthology : P27169
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A1
Gene start: 5168090
Gene end: 5193946
  
Corresponding Affymetrix probe sets: 10542983 (MoGene1.0st)   1418190_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002663
Ensembl peptide - ENSMUSP00000135195
Ensembl peptide - ENSMUSP00000135728
NCBI entrez gene - 18979     See in Manteia.
MGI - MGI:103295
RefSeq - XM_006505011
RefSeq - XM_011241049
RefSeq - NM_011134
RefSeq Peptide - NP_035264
swissprot - P52430
swissprot - H3BLB8
swissprot - H3BK03
Ensembl - ENSMUSG00000002588
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pon1ENSDARG00000032496Danio rerio
 pon2ENSDARG00000016856Danio rerio
 pon3.2ENSDARG00000097789Danio rerio
 pon3.2ENSDARG00000040290Danio rerio
 PON2ENSGALG00000009689Gallus gallus
 PON1ENSG00000005421Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pon2 / Q62086 / Serum paraoxonase/arylesterase 2 / Q15165* / paraoxonase 2*ENSMUSG0000003266764
Pon3 / Q62087 / Serum paraoxonase/lactonase 3 / Q15166* / paraoxonase 3*ENSMUSG0000002975958


Protein motifs (from Interpro)
Interpro ID Name
 IPR002640  Arylesterase
 IPR008363  Paraoxonase1
 IPR011042  Six-bladed beta-propeller, TolB-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008015 blood circulation TAS
 biological_processGO:0008203 cholesterol metabolic process TAS
 biological_processGO:0009636 response to toxic substance IMP
 biological_processGO:0010875 positive regulation of cholesterol efflux IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0019439 aromatic compound catabolic process IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032411 positive regulation of transporter activity IEA
 biological_processGO:0046395 carboxylic acid catabolic process IEA
 biological_processGO:0046434 organophosphate catabolic process IEA
 biological_processGO:0046470 phosphatidylcholine metabolic process IEA
 biological_processGO:0051099 positive regulation of binding IEA
 biological_processGO:0070542 response to fatty acid IEA
 biological_processGO:1902617 response to fluoride IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0034364 high-density lipoprotein particle ISO
 cellular_componentGO:0034366 spherical high-density lipoprotein particle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004063 aryldialkylphosphatase activity ISO
 molecular_functionGO:0004064 arylesterase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0008035 high-density lipoprotein particle binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0102007 acyl-L-homoserine-lactone lactonohydrolase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of 5-eicosatetraenoic acids


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pon1tm1Lus/Pon1tm1Lus
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002588 Pon1 / P52430 / paraoxonase 1 / P27169*  / complex






 

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