| MP:0000182 | increased circulating LDL cholesterol level | "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0000186 | decreased circulating HDL cholesterol level | "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0000611 | jaundice | "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0001260 | increased body weight | "greater than normal average weight " [J:33400] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0001547 | abnormal lipid level | "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0001860 | liver inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0002644 | decreased circulating triglyceride level | "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0002702 | decreased circulating free fatty acid level | "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0002830 | gallstones | "caliculi in the gallbladder or a bile duct; chemical composition of cholesterol, calcium carbonate or calcium bilirubinate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0002941 | increased circulating alanine transaminase level | "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0003674 | oxidative stress | "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
|
| MP:0003887 | increased hepatocyte apoptosis | "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
|
| MP:0004773 | abnormal bile composition | "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
|
| MP:0004789 | increased bile salt level | "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
|
| MP:0004921 | decreased placenta weight | "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024
|
| MP:0005178 | increased total circulating cholesterol level | "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0005290 | decreased oxygen consumption | "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0005339 | increased susceptibility to atherosclerosis | "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0005343 | increased circulating aspartate transaminase level | "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204] |
Show
Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0005344 | increased circulating bilirubin level | "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204] |
Show
Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0005365 | abnormal bile salt homeostasis | "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0005658 | susceptibility to diet-induced obesity | "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator] |
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Allelic Composition: Tmprss6hem8/Tmprss6tm1Dgen
Genetic Background: involves: C57BL/6 * C57BL/6J
|
| MP:0008469 | abnormal protein level | "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
|
| MP:0009118 | increased white fat cell size | "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
|
| MP:0009121 | increased white fat cell lipid droplet size | "increase in the size of the single large lipid droplet or vacuole of white fat cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
|
| MP:0009285 | increased gonadal fat pad weight | "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
|
| MP:0009304 | increased retroperitoneal fat pad weight | |
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
|
| MP:0009356 | decreased liver triglyceride level | "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
|
| MP:0009431 | decreased fetal weight | "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024
|
| MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
|
| MP:0010027 | increased liver cholesterol level | "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
|
| MP:0010934 | increased subcutaneous adipose tissue amount | "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
|
| MP:0010956 | abnormal mitochondrial ATP synthesis coupled electron transport | "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
|
| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024
|
| MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024
|
| MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: PhexMhdabap024/PhexMhdabap024
Genetic Background: C3HeB/FeJ-PhexMhdabap024
|
| MP:0012338 | decreased bile salt level | "reduced level of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith] |
Show
Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
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| MP:0012604 | decreased glutathione level | |
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Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA
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| MP:0014172 | decreased fatty acid oxidation | |
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Allelic Composition: Pon3tm1Dmsh/Pon3tm1Dmsh
Genetic Background: B6J.129X1-Pon3tm1Dmsh
|
