Manteia - Molecule gene

ENSMUSG00000002660

Mus musculus

Features

Gene ID:	ENSMUSG00000002660

Biological name :	Clpp

Synonyms :	ATP-dependent Clp protease proteolytic subunit, mitochondrial / Clpp / O88696

Possible biological names infered from orthology :	caseinolytic mitochondrial matrix peptidase proteolytic subunit / Q16740

Species:	Mus musculus

Chr. number:	17
Strand:	1
Band:	D
Gene start:	56990264
Gene end:	56996371

Corresponding Affymetrix probe sets:	10446207 (MoGene1.0st) 1416615_at (Mouse Genome 430 2.0 Array) 1416616_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000002735 NCBI entrez gene - 53895 See in Manteia. MGI - MGI:1858213 RefSeq - NM_017393 RefSeq Peptide - NP_059089 swissprot - O88696 Ensembl - ENSMUSG00000002660

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
clpp	ENSDARG00000020679	Danio rerio
CLPP	ENSG00000125656	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001907	ATP-dependent Clp protease proteolytic subunit
IPR018215	ClpP, Ser active site
IPR023562	Clp protease proteolytic subunit /Translocation-enhancing protein TepA
IPR029045	ClpP/crotonase-like domain superfamily
IPR033135	ClpP, histidine active site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	ISA
biological_process	GO:0051260	protein homooligomerization	IEA
biological_process	GO:0051603	proteolysis involved in cellular protein catabolic process	IEA
cellular_component	GO:0005739	mitochondrion	ISO
cellular_component	GO:0005759	mitochondrial matrix	ISO
cellular_component	GO:0009368	endopeptidase Clp complex	IEA
molecular_function	GO:0004252	serine-type endopeptidase activity	ISO
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008233	peptidase activity	IEA
molecular_function	GO:0008236	serine-type peptidase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0042802	identical protein binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000220	increased monocyte count	"greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0001127	small ovary	"reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0001155	arrest of spermatogenesis	"block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0001194	dermatitis	"inflammation of the skin" [J:65146]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0001489	decreased startle reflex	"greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0001828	abnormal T cell activation	"anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001931	abnormal oogenesis	"atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0002590	increased mean corpuscular volume	"greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002680	decreased number of corpora lutea	"fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0002757	reduced vertical activity	"lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0003795	abnormal bone structure		Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005011	increased eosinophil count	"greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005159	azoospermia	"absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0005344	increased circulating bilirubin level	"greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005561	increased mean corpuscular hemoglobin	"greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0008008	early cellular replicative senescence	"increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0008040	decreased NK T cell number	"reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0008044	increased NK cell number	"greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0008210	increased mature B cell number	"greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0008347	decreased gamma-delta T cell number	"reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0008805	decreased circulating amylase level	"reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0008810	increased circulating iron level	"elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0008868	abnormal granulosa cell morphology	"any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0010088	decreased circulating fructosamine level	"decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010182	decreased susceptibility to weight gain	"smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0010845	decreased effector memory CD4-positive, alpha-beta T cell number	"reduced number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010851	decreased effector memory CD8-positive, alpha-beta T cell number	"reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0010954	abnormal cellular respiration	"anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0011630	increased mitochondria size	"enlarged the cellular organelles responsible for energy production" [MGI:csmith]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0011636	disorganized mitochondrial cristae	"derangement of the pattern of the inward folds of the mitochondrial inner membrane" [MGI:csmith]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0011638	abnormal mitochondrial chromosome morphology	"any structrual anomaly of the chromosome found in the mitochondrion of a eukaryotic cell" [GO:0000262]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0011750	abnormal seminiferous tubule epithelium morphology	"any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0012765	decreased alpha-beta T cell number	"reduced number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0012767	increased KLRG1-positive NK cell number	"increase in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation" [MGI:Annie_Speak, PMID:19479342]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013022	increased Ly6C high monocyte number	"increase in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013025	increased Ly6C low monocyte number	"increase in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]	Show Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0013504	increased embryonic tissue cell apoptosis	"increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]	Show Allelic Composition: Clpp^{Gt(IST13563G11)Tigm}/Clpp^{Gt(IST13563G11)Tigm} Genetic Background: involves: C57BL/6N
MP:0013508	increased granulosa cell apoptosis	"increase in the timing or the number of granulsa cells undergoing programmed cell death" [MGI:csmith]	Show Allelic Composition: Bmi1^tm1.1Lees/Bmi1^tm1.1Lees,Apc^tm2Cip/Apc⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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