ENSMUSG00000003808


Mus musculus

Features
Gene ID: ENSMUSG00000003808
  
Biological name :Farsa
  
Synonyms : Farsa / Phenylalanine--tRNA ligase alpha subunit / Q8C0C7
  
Possible biological names infered from orthology : phenylalanyl-tRNA synthetase alpha subunit / Q9Y285
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C2
Gene start: 84856989
Gene end: 84869257
  
Corresponding Affymetrix probe sets: 10573434 (MoGene1.0st)   1424907_a_at (Mouse Genome 430 2.0 Array)   1440063_at (Mouse Genome 430 2.0 Array)   1445003_at (Mouse Genome 430 2.0 Array)   1446301_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003906
Ensembl peptide - ENSMUSP00000120609
Ensembl peptide - ENSMUSP00000105376
NCBI entrez gene - 66590     See in Manteia.
MGI - MGI:1913840
RefSeq - NM_025648
RefSeq - XM_006531288
RefSeq Peptide - NP_079924
swissprot - E9PWY9
swissprot - Q8C0C7
swissprot - D6RIJ2
Ensembl - ENSMUSG00000003808
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 farsaENSDARG00000098825Danio rerio
 FARSAENSGALG00000040258Gallus gallus
 FARSAENSG00000179115Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002319  Phenylalanyl-tRNA synthetase
 IPR004529  Phenylalanyl-tRNA synthetase, class IIc, alpha subunit
 IPR006195  Aminoacyl-tRNA synthetase, class II
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006432 phenylalanyl-tRNA aminoacylation IEA
 biological_processGO:0043039 tRNA aminoacylation IEA
 biological_processGO:0051290 protein heterotetramerization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009328 phenylalanine-tRNA ligase complex IEA
 molecular_functionGO:0000049 tRNA binding IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004826 phenylalanine-tRNA ligase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0003795 abnormal bone structure 
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Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0005634 decreased circulating sodium level "less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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