ENSMUSG00000003865


Mus musculus

Features
Gene ID: ENSMUSG00000003865
  
Biological name :Gys1
  
Synonyms : Glycogen [starch] synthase, muscle / Gys1 / Q9Z1E4
  
Possible biological names infered from orthology : glycogen synthase 1 / P13807
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 45434844
Gene end: 45456619
  
Corresponding Affymetrix probe sets: 10552945 (MoGene1.0st)   1416737_at (Mouse Genome 430 2.0 Array)   1450196_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003964
Ensembl peptide - ENSMUSP00000148252
Ensembl peptide - ENSMUSP00000147424
NCBI entrez gene - 14936     See in Manteia.
MGI - MGI:101805
RefSeq - NM_030678
RefSeq Peptide - NP_109603
swissprot - A0A1B0GT92
swissprot - A0A1B0GR90
swissprot - Q9Z1E4
Ensembl - ENSMUSG00000003865
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gys1ENSDARG00000016875Danio rerio
 GYS1ENSG00000104812Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gys2 / Q8VCB3 / Glycogen [starch] synthase, liver / P54840* / glycogen synthase 2*ENSMUSG0000003024467


Protein motifs (from Interpro)
Interpro ID Name
 IPR008631  Glycogen synthase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0005978 glycogen biosynthetic process IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016234 inclusion body IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004373 glycogen (starch) synthase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005536 glucose binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0061547 glycogen synthase activity, transferring glucose-1-phosphate ISO


Pathways (from Reactome)
Pathway description
Glycogen synthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000255 vasculature congestion "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000950 pharmacologically induced seizures "seizure activity that is brought about by treatment with pharmacological agents" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: D2.B10-Dmdmdx/J

Allelic Composition: Nhlrc1tm1(KOMP)Vlcg/Nhlrc1tm1(KOMP)Vlcg,Gys1tm1a(EUCOMM)Wtsi/Gys1+,Tg(Nes-cre)1Kag/?
Genetic Background: involves: C57BL/6NTac

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0001650 electrically induced seizures "high or low frequency electrical stimulation applied to induce seizure activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
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Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: D2.B10-Dmdmdx/J

Allelic Composition: Nhlrc1tm1(KOMP)Vlcg/Nhlrc1tm1(KOMP)Vlcg,Gys1tm1a(EUCOMM)Wtsi/Gys1+,Tg(Nes-cre)1Kag/?
Genetic Background: involves: C57BL/6NTac

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002714 elevated glycogen catabolism rate "increased breakdown of this highly branched polysaccharide composed of glucose subunits; glycogen is the major carbohydrate storage form in the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002803 abnormal operant conditional behavior "defects in the operant conditioning system refers to abnormalities in scheduled controlled behavior; behavioral assessment occurs in an automated chamber where responses are reinforced with food" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nhlrc1tm1(KOMP)Vlcg/Nhlrc1tm1(KOMP)Vlcg,Gys1tm1a(EUCOMM)Wtsi/Gys1+,Tg(Nes-cre)1Kag/?
Genetic Background: involves: C57BL/6NTac

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004130 abnormal muscle cell glucose uptake "anomaly in the ability of muscle cells to take in glucose" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Gys1tm1.1Arte/Gys1+
Genetic Background: involves: C57BL/6J

Allelic Composition: Gsk3atm1Dral/Gsk3atm1Dral,Gsk3btm1Dral/Gsk3btm1Dral,Gys1tm1.1Arte/Gys1tm1.1Arte
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Nhlrc1tm1(KOMP)Vlcg/Nhlrc1tm1(KOMP)Vlcg,Gys1tm1a(EUCOMM)Wtsi/Gys1+,Tg(Nes-cre)1Kag/?
Genetic Background: involves: C57BL/6NTac

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010399 decreased skeletal muscle glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Gys1tm1.1Arte/Gys1+
Genetic Background: involves: C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Alx4Lst-2J/Alx4lst-J
Genetic Background: involves: C3H/FeJLe * C57BL/6J

 MP:0012501 abnormal pericardial cavity morphology "any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [MGI:anna]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0014075 decreased brain glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in brain" [MGI:csmith]
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Allelic Composition: Brinp1tm1.1Pib/Brinp1+
Genetic Background: involves: BALB/cJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019528 Gyg / Q9R062 / glycogenin / GYG1* / P46976* / glycogenin 1*  / complex
 ENSMUSG00000055493 Epm2a / Q9WUA5 / Laforin / O95278* / EPM2A, laforin glucan phosphatase*  / reaction
 ENSMUSG00000003865 Gys1 / Q9Z1E4 / Glycogen [starch] synthase, muscle / P13807* / glycogen synthase 1*  / complex
 ENSMUSG00000067279 Q7TMB3 / Ppp1r3c / Protein phosphatase 1 regulatory subunit 3C / Q9UQK1*  / reaction / complex
 ENSMUSG00000022707 Gbe1 / Q9D6Y9 / 1,4-alpha-glucan-branching enzyme / Q04446* / 1,4-alpha-glucan branching enzyme 1*  / reaction






 

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