Manteia - Molecule gene

ENSMUSG00000030244

Mus musculus

Features

Gene ID:	ENSMUSG00000030244

Biological name :	Gys2

Synonyms :	Glycogen [starch] synthase, liver / Gys2 / Q8VCB3

Possible biological names infered from orthology :	glycogen synthase 2 / P54840

Species:	Mus musculus

Chr. number:	6
Strand:	-1
Band:	G2
Gene start:	142422613
Gene end:	142473109

Corresponding Affymetrix probe sets:	10549079 (MoGene1.0st) 1424815_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000145213 Ensembl peptide - ENSMUSP00000032371 NCBI entrez gene - 232493 See in Manteia. MGI - MGI:2385254 RefSeq - NM_145572 RefSeq - XM_006506957 RefSeq Peptide - NP_663547 swissprot - A0A0N4SVR4 swissprot - Q8VCB3 Ensembl - ENSMUSG00000030244

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
gys2	ENSDARG00000004904	Danio rerio
GYS2	ENSGALG00000013265	Gallus gallus
GYS2	ENSG00000111713	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gys1 / Q9Z1E4 / Glycogen [starch] synthase, muscle / P13807* / glycogen synthase 1*	ENSMUSG00000003865	70

Protein motifs (from Interpro)

Interpro ID	Name
IPR008631	Glycogen synthase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0005978	glycogen biosynthetic process	ISO
biological_process	GO:0008152	metabolic process	IEA
biological_process	GO:0009749	response to glucose	ISS
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005829	cytosol	ISS
cellular_component	GO:0005856	cytoskeleton	ISS
cellular_component	GO:0005938	cell cortex	ISS
cellular_component	GO:0030864	cortical actin cytoskeleton	ISS
cellular_component	GO:0043265	ectoplasm	ISS
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0004373	glycogen (starch) synthase activity	ISO
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0016757	transferase activity, transferring glycosyl groups	IEA

Pathways (from Reactome)

Pathway description

Glycogen synthesis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000187	abnormal triglyceride level	"anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gys2^tm1.1Pro/Gys2^tm1.1Pro,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA
MP:0000194	hypercalcemia	"abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fto^{tm1a(EUCOMM)Wtsi}/Fto^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Fto^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Fto^{tm1a(EUCOMM)Wtsi}/Fto^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Fto^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Sall1)Ryn}/Gt(ROSA)26Sor⁺,Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 Allelic Composition: Gys2^tm1.1Arte/Gys2^tm1.1Arte Genetic Background: Not Specified
MP:0002098	abnormal vibrissae morphology	"irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fto^{tm1a(EUCOMM)Wtsi}/Fto^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Fto^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002715	reduced glycogen catabolism rate	"decreased breakdown of this highly branched polysaccharide composed of glucose subunits; glycogen is the major carbohydrate storage form in the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gys2^tm1.1Pro/Gys2^tm1.1Pro,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA Allelic Composition: Gys2^tm1.1Arte/Gys2⁺ Genetic Background: Not Specified Allelic Composition: Gys2^tm1.1Arte/Gys2^tm1.1Arte Genetic Background: Not Specified
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Gys2^tm1.1Pro/Gys2^tm1.1Pro,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA Allelic Composition: Gys2^tm1.1Arte/Gys2^tm1.1Arte Genetic Background: Not Specified
MP:0002834	decreased heart weight	"less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Gys2^tm1.1Pro/Gys2^tm1.1Pro,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA
MP:0003019	increased circulating chloride level	"elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Gys2^{tm1a(KOMP)Wtsi}/Gys2^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Gys2^{tm1a(KOMP)Wtsi}/Wtsi
MP:0003383	abnormal gluconeogenesis	"anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]	Show Allelic Composition: Gys2^tm1.1Pro/Gys2^tm1.1Pro,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA Allelic Composition: Gys2^tm1.1Arte/Gys2^tm1.1Arte Genetic Background: Not Specified
MP:0003402	decreased liver weight	"reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gys2^tm1.1Pro/Gys2^tm1.1Pro,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA
MP:0003442	decreased circulating glycerol level	"lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gys2^{tm1a(KOMP)Wtsi}/Gys2^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Gys2^{tm1a(KOMP)Wtsi}/Wtsi
MP:0003457	abnormal circulating ketone body level	"aberrant amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gys2^tm1.1Pro/Gys2^tm1.1Pro,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gys2^tm1.1Pro/Gys2^tm1.1Pro,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA Allelic Composition: Gys2^tm1.1Arte/Gys2⁺ Genetic Background: Not Specified Allelic Composition: Gys2^tm1.1Arte/Gys2^tm1.1Arte Genetic Background: Not Specified
MP:0005331	insulin resistance	"diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Gys2^tm1.1Arte/Gys2^tm1.1Arte Genetic Background: Not Specified
MP:0005439	decreased glycogen level	"less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gys2^tm1.1Pro/Gys2^tm1.1Pro,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gys2^tm1.1Pro/Gys2^tm1.1Pro,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA Allelic Composition: Gys2^tm1.1Arte/Gys2^tm1.1Arte Genetic Background: Not Specified Allelic Composition: Gys2^{tm1a(KOMP)Wtsi}/Gys2^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Gys2^{tm1a(KOMP)Wtsi}/Wtsi
MP:0005568	increased circulating total protein level	"greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]	Show Allelic Composition: Gys2^{tm1a(KOMP)Wtsi}/Gys2^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Gys2^{tm1a(KOMP)Wtsi}/Wtsi
MP:0005633	increased circulating sodium level	"greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Gys2^{tm1a(KOMP)Wtsi}/Gys2^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Gys2^{tm1a(KOMP)Wtsi}/Wtsi
MP:0006263	decreased diastolic blood pressure	"abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]	Show Allelic Composition: Gys2^tm1.1Pro/Gys2^tm1.1Pro,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA
MP:0009355	increased liver triglyceride level	"higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gys2^tm1.1Pro/Gys2^tm1.1Pro,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA Allelic Composition: Gys2^tm1.1Arte/Gys2⁺ Genetic Background: Not Specified Allelic Composition: Gys2^tm1.1Arte/Gys2^tm1.1Arte Genetic Background: Not Specified
MP:0010080	abnormal hepatocyte physiology	"any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gys2^tm1.1Arte/Gys2⁺ Genetic Background: Not Specified Allelic Composition: Gys2^tm1.1Arte/Gys2^tm1.1Arte Genetic Background: Not Specified
MP:0010398	decreased liver glycogen level	"less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghrhr^lit/Ghrhr^lit Genetic Background: C3.B6-Ghrhr^lit/J Allelic Composition: Gys2^tm1.1Arte/Gys2^tm1.1Arte Genetic Background: Not Specified
MP:0012106	impaired exercise endurance	"impaired performance during controlled physical activity" [MGI:smb]	Show Allelic Composition: Gys2^tm1.1Pro/Gys2^tm1.1Pro,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA
MP:0030020	decreased cardiac cell glucose uptake	"reduced ability of the cells of the heart to take in glucose" [MGI:anna]	Show Allelic Composition: Gys2^tm1.1Pro/Gys2^tm1.1Pro,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr