ENSMUSG00000003923


Mus musculus

Features
Gene ID: ENSMUSG00000003923
  
Biological name :Tfam
  
Synonyms : P40630 / Tfam / transcription factor A, mitochondrial
  
Possible biological names infered from orthology : Q00059
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B5.3
Gene start: 71225464
Gene end: 71238280
  
Corresponding Affymetrix probe sets: 10369867 (MoGene1.0st)   1448224_at (Mouse Genome 430 2.0 Array)   1456215_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101072
Ensembl peptide - ENSMUSP00000120871
Ensembl peptide - ENSMUSP00000113581
Ensembl peptide - ENSMUSP00000090086
NCBI entrez gene - 21780     See in Manteia.
MGI - MGI:107810
RefSeq - NM_009360
RefSeq - XM_017313918
RefSeq Peptide - NP_033386
swissprot - D3Z0F3
swissprot - P40630
swissprot - A0A0R4J1N9
Ensembl - ENSMUSG00000003923
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfamENSDARG00000063145Danio rerio
 TFAMENSGALG00000002703Gallus gallus
 TFAMENSG00000108064Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006390 mitochondrial transcription ISO
 biological_processGO:0006391 transcription initiation from mitochondrial promoter ISO
 biological_processGO:0033108 mitochondrial respiratory chain complex assembly IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex TAS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042645 mitochondrial nucleoid ISS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001018 mitochondrial promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001223 transcription coactivator binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0008301 DNA binding, bending ISS
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Mitochondrial transcription initiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000233 abnormal blood flow velocity "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Tfamtm1.1Ncdl/Tfamtm1.1Ncdl,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000648 absent sebaceous gland "missing the holocrine glands of the dermis that secrete sebum into the hair follicles" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Tfamtm1.1Ncdl/Tfamtm1.1Ncdl,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000743 muscle spasms "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001105 abnormal PNS glia "malformation or absence of non-neuronal cells that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Tfamtm1.1Ncdl/Tfamtm1.1Ncdl,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm1Bird/Y,Ssttm2.1(cre)Zjh/Sst+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001333 absent optic nerve "absence of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja5tm1Lumi/Gja5+,Irx3tm1Hui/Irx3tm1Hui
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Myhca-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Tfamtm1.1Ncdl/Tfamtm1.1Ncdl,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tfamtm1.1Ncdl/Tfamtm1.1Ncdl,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Myhca-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Myhca-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Myhca-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Prkntm1Roo/Prkntm1Roo,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Myhca-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Myhca-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Myhca-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfamtm1.1Ncdl/Tfamtm1.1Ncdl,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003244 loss of dopaminergic neurons "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Prkntm1Roo/Prkntm1Roo,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
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Allelic Composition: Tfamtm1.1Ncdl/Tfamtm1.1Ncdl,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0004143 hypertonia "increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004191 neuronal intranuclear inclusions "presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington s disease" [acv:Alicia Valenzuela_Genetic Resources Curator]
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Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Sncatm1Nbm/Sncatm1Nbm,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Prkntm1Roo/Prkntm1Roo,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Myhca-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Lrsn/Slc6a3+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Tfamtm1.1Ncdl/Tfamtm1.1Ncdl,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfamtm1.1Ncdl/Tfamtm1.1Ncdl,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfamtm1.1Ncdl/Tfamtm1.1Ncdl,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008859 abnormal hair cycle catagen phase "anomaly in the phase of the hair growth cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored hair is produced" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfamtm1.1Ncdl/Tfamtm1.1Ncdl,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009004 progressive hair loss "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfamtm1.1Ncdl/Tfamtm1.1Ncdl,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0009174 absent pancreatic beta cells "absence of the cells of the pancreas that secrete insulin" [MESH:A03.734.414.131]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Myhca-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfamtm1.1Ncdl/Tfamtm1.1Ncdl,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Myhca-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Myl1tm1(cre)Sjb/Myl1+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Myhca-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0011602 increased glutathione peroxidase activity "greater ability to catalyze the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O" [GO:0004602]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0011636 disorganized mitochondrial cristae "derangement of the pattern of the inward folds of the mitochondrial inner membrane" [MGI:csmith]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020329 Polrmt / Q8BKF1 / polymerase (RNA) mitochondrial (DNA directed) / O00411* / RNA polymerase mitochondrial*  / reaction / complex
 ENSMUSG00000026492 Tfb2m / Q3TL26 / transcription factor B2, mitochondrial / Q9H5Q4*  / reaction / complex






 

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