ENSMUSG00000020329


Mus musculus

Features
Gene ID: ENSMUSG00000020329
  
Biological name :Polrmt
  
Synonyms : Polrmt / polymerase (RNA) mitochondrial (DNA directed) / Q8BKF1
  
Possible biological names infered from orthology : O00411 / RNA polymerase mitochondrial
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 79736123
Gene end: 79746581
  
Corresponding Affymetrix probe sets: 10370610 (MoGene1.0st)   1437377_a_at (Mouse Genome 430 2.0 Array)   1452835_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124230
Ensembl peptide - ENSMUSP00000124936
Ensembl peptide - ENSMUSP00000124556
Ensembl peptide - ENSMUSP00000020580
NCBI entrez gene - 216151     See in Manteia.
MGI - MGI:1915843
RefSeq - NM_172551
RefSeq Peptide - NP_766139
swissprot - Q3U3J3
swissprot - E9PWD9
swissprot - Q8BKF1
swissprot - E0CY15
swissprot - F6TLB0
Ensembl - ENSMUSG00000020329
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polrmtENSDARG00000101220Danio rerio
 POLRMTENSGALG00000001377Gallus gallus
 O00411ENSG00000099821Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002092  DNA-directed RNA polymerase, phage-type
 IPR002885  Pentatricopeptide repeat
 IPR024075  DNA-directed RNA polymerase, helix hairpin domain superfamily
 IPR029262  DNA-directed RNA polymerase, N-terminal
 IPR037159  DNA-directed RNA polymerase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006390 mitochondrial transcription IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0034245 mitochondrial DNA-directed RNA polymerase complex IBA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003899 DNA-directed 5"-3" RNA polymerase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Mitochondrial transcription initiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0003929 decreased heart rate variability "reduced variation of beat-to-beat intervals of the heart, usually indicitive of cardiac disease" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Saa3tm1(KOMP)Vlcg/Saa3+
Genetic Background: involves: C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003923 Tfam / P40630 / transcription factor A, mitochondrial / Q00059*  / reaction / complex
 ENSMUSG00000026492 Tfb2m / Q3TL26 / transcription factor B2, mitochondrial / Q9H5Q4*  / complex






 

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