ENSMUSG00000003949


Mus musculus

Features
Gene ID: ENSMUSG00000003949
  
Biological name :Hlf
  
Synonyms : Hepatic leukemia factor / Hlf / Q8BW74
  
Possible biological names infered from orthology : HLF, PAR bZIP transcription factor / Q16534
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: C
Gene start: 90336536
Gene end: 90390895
  
Corresponding Affymetrix probe sets: 10389786 (MoGene1.0st)   1434735_at (Mouse Genome 430 2.0 Array)   1434736_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004051
Ensembl peptide - ENSMUSP00000135463
NCBI entrez gene - 217082     See in Manteia.
MGI - MGI:96108
RefSeq - XM_006533007
RefSeq - NM_172563
RefSeq - XM_006533004
RefSeq - XM_006533005
RefSeq - XM_006533006
RefSeq Peptide - NP_766151
swissprot - Q8BW74
swissprot - H3BKN8
Ensembl - ENSMUSG00000003949
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hlfaENSDARG00000074752Danio rerio
 hlfbENSDARG00000061011Danio rerio
 HLFENSGALG00000003059Gallus gallus
 HLFENSG00000108924Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tef / Q9JLC6 / Thyrotroph embryonic factor / Q10587* / TEF, PAR bZIP transcription factor*ENSMUSG0000002238952
Dbp / Q60925 / D site-binding protein / Q10586* / D-box binding PAR bZIP transcription factor*ENSMUSG0000005982444


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR029829  Hepatic leukemia factor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048511 rhythmic process IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001496 audiogenic seizures "a reflex seizure triggered by loud noises" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gfra3tm1Wss/Gfra3tm1Wss
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gfra3tm1Wss/Gfra3tm1Wss
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gfra3tm1Wss/Gfra3tm1Wss
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Dbptm1Schb/Dbptm1Schb,Hlftm1Schb/Hlftm1Schb,Teftm1Schb/Tef+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gfra3tm1Wss/Gfra3tm1Wss
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Hlftm1Schb/Hlftm1Schb,Teftm1Schb/Teftm1Schb
Genetic Background: involves: 129S2/SvPas

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Gfra3tm1Wss/Gfra3tm1Wss
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0003216 absence seizures "impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gfra3tm1Wss/Gfra3tm1Wss
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Dbptm1Schb/Dbptm1Schb,Hlftm1Schb/Hlftm1Schb,Teftm1Schb/Tef+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gfra3tm1Wss/Gfra3tm1Wss
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gfra3tm1Wss/Gfra3tm1Wss
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Dbptm1Schb/Dbptm1Schb,Hlftm1Schb/Hlftm1Schb,Teftm1Schb/Tef+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gfra3tm1Wss/Gfra3tm1Wss
Genetic Background: involves: 129X1/SvJ * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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