ENSMUSG00000004558


Mus musculus

Features
Gene ID: ENSMUSG00000004558
  
Biological name :Ndrg2
  
Synonyms : Ndrg2 / Protein NDRG2 Protein NDRG2, N-terminally processed / Q9QYG0
  
Possible biological names infered from orthology : NDRG family member 2 / Q9UN36
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C1
Gene start: 51905271
Gene end: 51914158
  
Corresponding Affymetrix probe sets: 10419578 (MoGene1.0st)   1448154_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004673
Ensembl peptide - ENSMUSP00000107259
Ensembl peptide - ENSMUSP00000154279
Ensembl peptide - ENSMUSP00000154716
Ensembl peptide - ENSMUSP00000153830
Ensembl peptide - ENSMUSP00000153938
Ensembl peptide - ENSMUSP00000154135
NCBI entrez gene - 29811     See in Manteia.
MGI - MGI:1352498
RefSeq - XM_017316052
RefSeq - NM_001145959
RefSeq - NM_013864
RefSeq - XM_017316049
RefSeq - XM_017316050
RefSeq - XM_017316051
RefSeq - XM_006519098
RefSeq - XM_006519099
RefSeq - XM_006519103
RefSeq - XM_006519104
RefSeq - XM_006519105
RefSeq - XM_017316045
RefSeq - XM_017316046
RefSeq - XM_017316047
RefSeq - XM_017316048
RefSeq Peptide - NP_038892
RefSeq Peptide - NP_001139431
swissprot - Q9QYG0
Ensembl - ENSMUSG00000004558
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndrg2ENSDARG00000011170Danio rerio
 NDRG2ENSG00000165795Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ndrg3 / Q9QYF9 / Mus musculus N-myc downstream regulated 3 (Ndrg3), transcript variant 6, mRNA. / Q9UGV2* / NDRG family member 3*ENSMUSG0000002763458
Ndrg4 / Q8BTG7 / Protein NDRG4 / Q9ULP0* / NDRG family member 4*ENSMUSG0000003656457
Ndrg1 / Q62433 / Protein NDRG1 / Q92597* / N-myc downstream regulated 1*ENSMUSG0000000512553


Protein motifs (from Interpro)
Interpro ID Name
 IPR004142  NDRG
 IPR029058  Alpha/Beta hydrolase fold
 IPR030690  Protein NDRG2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001818 negative regulation of cytokine production IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007420 brain development IBA
 biological_processGO:0010574 regulation of vascular endothelial growth factor production IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IDA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0090361 regulation of platelet-derived growth factor production IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

Allelic Composition: Ndrg2tm1Kmori/Ndrg2+
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

Allelic Composition: Ndrg2tm1Kmori/Ndrg2+
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

Allelic Composition: Ndrg2tm1Kmori/Ndrg2+
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhotm1Phm/Rhotm1Phm,Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Ndrg2tm1Xzg/Ndrg2tm1Xzg,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Ndrg2tm1.1Xzg/Ndrg2tm1.1Xzg
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

Allelic Composition: Ndrg2tm1.1Xzg/Ndrg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

Allelic Composition: Ndrg2tm1Kmori/Ndrg2+
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0003690 abnormal glial cell physiology "anomalous function of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhotm1Phm/Rhotm1Phm,Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Ndrg2tm1Xzg/Ndrg2tm1Xzg,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Ndrg2tm1.1Xzg/Ndrg2tm1.1Xzg
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

Allelic Composition: Ndrg2tm1.1Xzg/Ndrg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0004617 sacral vertebral transformation "homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhotm1Phm/Rhotm1Phm,Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Ndrg2tm1Xzg/Ndrg2tm1Xzg,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Ndrg2tm1.1Xzg/Ndrg2tm1.1Xzg
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

Allelic Composition: Ndrg2tm1.1Xzg/Ndrg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhotm1Phm/Rhotm1Phm,Tg(Rho*G90D*A337V)202Sie/Tg(Rho*G90D*A337V)202Sie
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Ndrg2tm1Xzg/Ndrg2tm1Xzg,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Ndrg2tm1.1Xzg/Ndrg2tm1.1Xzg
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

Allelic Composition: Ndrg2tm1.1Xzg/Ndrg2+
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0006262 testis tumor "presence of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:60034]
Show

Allelic Composition: Ndrg2tm1Kmori/Ndrg2+
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

Allelic Composition: Ndrg2tm1Kmori/Ndrg2+
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

Allelic Composition: Ndrg2tm1Kmori/Ndrg2+
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0009153 pancreas tumor "tumors or cancer of the pancreas" [MESH:C04.588.274.761]
Show

Allelic Composition: Ndrg2tm1Kmori/Ndrg2+
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0009277 brain tumor "presence of abnormal rapidly proliferating cells in the brain, usually in the form of a distinct mass" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ndrg2tm1Kmori/Ndrg2+
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ndrg2tm1Kmori/Ndrg2+
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ndrg2tm1Kmori/Ndrg2+
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0010761 abnormal microglial cell chemotaxis "anomaly in the movement of a microglial cell guided by a specific chemical concentration gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Ctnna1Tvrm5/Ctnna1+
Genetic Background: C57BL/6J-Ctnna1Tvrm5/Pjn

Allelic Composition: Ndrg2tm1Kmori/Ndrg2+
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0012066 decreased astrocyte number "reduction in the number of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord" [CL:0000127, MGI:csmith]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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