ENSMUSG00000036564


Mus musculus

Features
Gene ID: ENSMUSG00000036564
  
Biological name :Ndrg4
  
Synonyms : Ndrg4 / Protein NDRG4 / Q8BTG7
  
Possible biological names infered from orthology : NDRG family member 4 / Q9ULP0
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D1
Gene start: 95676980
Gene end: 95715119
  
Corresponding Affymetrix probe sets: 10574384 (MoGene1.0st)   1426615_s_at (Mouse Genome 430 2.0 Array)   1436188_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079495
Ensembl peptide - ENSMUSP00000148779
Ensembl peptide - ENSMUSP00000148614
Ensembl peptide - ENSMUSP00000148590
Ensembl peptide - ENSMUSP00000131203
Ensembl peptide - ENSMUSP00000125703
Ensembl peptide - ENSMUSP00000036226
Ensembl peptide - ENSMUSP00000072883
NCBI entrez gene - 234593     See in Manteia.
MGI - MGI:2384590
RefSeq - XM_006530869
RefSeq - NM_001195006
RefSeq - NM_145602
RefSeq - XM_006530867
RefSeq - XM_006530868
RefSeq Peptide - NP_001181935
RefSeq Peptide - NP_663577
swissprot - A0A1D5RMH3
swissprot - A0A1D5RM37
swissprot - A0A1D5RM17
swissprot - Q8BTG7
swissprot - E0CZ50
swissprot - E9Q168
Ensembl - ENSMUSG00000036564
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndrg4ENSDARG00000103937Danio rerio
 NDRG4ENSGALG00000043662Gallus gallus
 NDRG4ENSG00000103034Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ndrg3 / Q9QYF9 / Mus musculus N-myc downstream regulated 3 (Ndrg3), transcript variant 6, mRNA. / Q9UGV2* / NDRG family member 3*ENSMUSG0000002763464
Ndrg2 / Q9QYG0 / Protein NDRG2 Protein NDRG2, N-terminally processed / Q9UN36* / NDRG family member 2*ENSMUSG0000000455860
Ndrg1 / Q62433 / Protein NDRG1 / Q92597* / N-myc downstream regulated 1*ENSMUSG0000000512560


Protein motifs (from Interpro)
Interpro ID Name
 IPR004142  NDRG
 IPR029058  Alpha/Beta hydrolase fold
 IPR030695  Protein NDRG4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007420 brain development IBA
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway ISO
 biological_processGO:0014912 negative regulation of smooth muscle cell migration ISO
 biological_processGO:0048278 vesicle docking IMP
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation ISO
 biological_processGO:0060973 cell migration involved in heart development IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:2001135 regulation of endocytic recycling IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016323 basolateral plasma membrane ISO
 cellular_componentGO:0031253 cell projection membrane IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Mertknmf12/Mertknmf12,Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6J

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mertknmf12/Mertknmf12,Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6J

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Mertknmf12/Mertknmf12,Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mertknmf12/Mertknmf12,Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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