ENSMUSG00000005125


Mus musculus

Features
Gene ID: ENSMUSG00000005125
  
Biological name :Ndrg1
  
Synonyms : Ndrg1 / Protein NDRG1 / Q62433
  
Possible biological names infered from orthology : N-myc downstream regulated 1 / Q92597
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D2
Gene start: 66929318
Gene end: 66969640
  
Corresponding Affymetrix probe sets: 10429140 (MoGene1.0st)   1420760_s_at (Mouse Genome 430 2.0 Array)   1423413_at (Mouse Genome 430 2.0 Array)   1450976_at (Mouse Genome 430 2.0 Array)   1450977_s_at (Mouse Genome 430 2.0 Array)   1456174_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126091
Ensembl peptide - ENSMUSP00000130584
Ensembl peptide - ENSMUSP00000130281
Ensembl peptide - ENSMUSP00000130150
Ensembl peptide - ENSMUSP00000129093
Ensembl peptide - ENSMUSP00000127940
Ensembl peptide - ENSMUSP00000127302
Ensembl peptide - ENSMUSP00000127099
Ensembl peptide - ENSMUSP00000127075
Ensembl peptide - ENSMUSP00000126985
Ensembl peptide - ENSMUSP00000005256
NCBI entrez gene - 17988     See in Manteia.
MGI - MGI:1341799
RefSeq - NM_008681
RefSeq Peptide - NP_032707
swissprot - E9Q514
swissprot - E9Q3F9
swissprot - E9Q147
swissprot - E9Q0J8
swissprot - E9PZC7
swissprot - E9PVF3
swissprot - F6VLR8
swissprot - Q545R3
swissprot - E9Q7V2
swissprot - Q62433
swissprot - E9Q7G8
swissprot - E9Q5I8
Ensembl - ENSMUSG00000005125
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndrg1aENSDARG00000032849Danio rerio
 ndrg1bENSDARG00000010420Danio rerio
 NDRG1ENSGALG00000035397Gallus gallus
 NDRG1ENSG00000104419Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ndrg3 / Q9QYF9 / Mus musculus N-myc downstream regulated 3 (Ndrg3), transcript variant 6, mRNA. / Q9UGV2* / NDRG family member 3*ENSMUSG0000002763461
Ndrg4 / Q8BTG7 / Protein NDRG4 / Q9ULP0* / NDRG family member 4*ENSMUSG0000003656454
Ndrg2 / Q9QYG0 / Protein NDRG2 Protein NDRG2, N-terminally processed / Q9UN36* / NDRG family member 2*ENSMUSG0000000455850


Protein motifs (from Interpro)
Interpro ID Name
 IPR004142  NDRG
 IPR029058  Alpha/Beta hydrolase fold
 IPR030693  Protein NDRG1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0032287 peripheral nervous system myelin maintenance IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045576 mast cell activation IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0090232 positive regulation of spindle checkpoint IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0043015 gamma-tubulin binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0000958 peripheral nervous system degeneration "a retrogressive impairment of function or destruction of the ganglia and peripheral nerves that lie outside the brain and spinal cord" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

Allelic Composition: Ndrg1tm1Hem/Ndrg1+
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0003207 decreased sensitivity to gamma-irradiation "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

Allelic Composition: Ndrg1tm1Hem/Ndrg1+
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

Allelic Composition: Ndrg1tm1Hem/Ndrg1+
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcna1mceph/Kcna1mceph
Genetic Background: BALB/cByJ-Kcna1mceph/J

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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