ENSMUSG00000004630


Mus musculus

Features
Gene ID: ENSMUSG00000004630
  
Biological name :Pcp2
  
Synonyms : P12660 / Pcp2 / Purkinje cell protein 2
  
Possible biological names infered from orthology : Q8IVA1
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.1
Gene start: 3623371
Gene end: 3625545
  
Corresponding Affymetrix probe sets: 10576749 (MoGene1.0st)   1419084_a_at (Mouse Genome 430 2.0 Array)   1419085_at (Mouse Genome 430 2.0 Array)   1424944_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121403
Ensembl peptide - ENSMUSP00000121079
Ensembl peptide - ENSMUSP00000122902
Ensembl peptide - ENSMUSP00000146683
Ensembl peptide - ENSMUSP00000146399
Ensembl peptide - ENSMUSP00000004749
NCBI entrez gene - 18545     See in Manteia.
MGI - MGI:97508
RefSeq - XM_006508733
RefSeq - NM_001129803
RefSeq - NM_001129804
RefSeq - NM_008790
RefSeq - XM_006508729
RefSeq - XM_006508730
RefSeq - XM_006508731
RefSeq - XM_006508732
RefSeq Peptide - NP_001123275
RefSeq Peptide - NP_032816
RefSeq Peptide - NP_001123276
swissprot - A0A140LHG1
swissprot - A0A0R4IZX8
swissprot - P12660
swissprot - A8IK50
swissprot - A0A140LI57
Ensembl - ENSMUSG00000004630
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PCP2ENSG00000174788Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpsm1 / Q6IR34 / Mus musculus G-protein signalling modulator 1 (AGS3-like, C. elegans) (Gpsm1), transcript variant 5, mRNA. / Q86YR5* / G protein signaling modulator 1*ENSMUSG0000002693032
Gpsm2 / Q8VDU0 / G-protein-signaling modulator 2 / P81274*ENSMUSG0000002788326
Ttc28 / Q80XJ3 / tetratricopeptide repeat domain 28 / Q96AY4*ENSMUSG0000003320924


Protein motifs (from Interpro)
Interpro ID Name
 IPR003109  GoLoco motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016056 rhodopsin mediated signaling pathway IMP
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0030695 GTPase regulator activity IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Runx2tm1Gss/Runx2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx2tm1Gss/Runx2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

Allelic Composition: Pcp2tm1Bhk/Pcp2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Pcp2tm1Jim/Pcp2tm1Jim
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grm1tm1Stl/Grm1tm1Stl,Pcp2tm1(tTA)23Atai/Pcp2+,Tg(tetO-Grm1)7Atai/?
Genetic Background: involves: 129S2/SvPas * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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