ENSMUSG00000026930


Mus musculus

Features
Gene ID: ENSMUSG00000026930
  
Biological name :Gpsm1
  
Synonyms : Gpsm1 / Mus musculus G-protein signalling modulator 1 (AGS3-like, C. elegans) (Gpsm1), transcript variant 5, mRNA. / Q6IR34
  
Possible biological names infered from orthology : G protein signaling modulator 1 / Q86YR5
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 26315515
Gene end: 26348237
  
Corresponding Affymetrix probe sets: 10470248 (MoGene1.0st)   1423689_a_at (Mouse Genome 430 2.0 Array)   1423690_s_at (Mouse Genome 430 2.0 Array)   1436917_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115680
Ensembl peptide - ENSMUSP00000109769
Ensembl peptide - ENSMUSP00000120934
Ensembl peptide - ENSMUSP00000065000
Ensembl peptide - ENSMUSP00000067964
Ensembl peptide - ENSMUSP00000077686
NCBI entrez gene - 67839     See in Manteia.
MGI - MGI:1915089
RefSeq - XM_017319226
RefSeq - NM_001199146
RefSeq - NM_001199147
RefSeq - NM_001355574
RefSeq - NM_001355575
RefSeq - NM_001355576
RefSeq - NM_153410
RefSeq - XM_006498253
RefSeq Peptide - NP_001342504
RefSeq Peptide - NP_001342505
RefSeq Peptide - NP_700459
RefSeq Peptide - NP_001186075
RefSeq Peptide - NP_001186076
RefSeq Peptide - NP_001342503
swissprot - Q6IR34
swissprot - F6SX81
swissprot - A2AIV4
swissprot - A2AIV3
Ensembl - ENSMUSG00000026930
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpsm1aENSDARG00000092517Danio rerio
 gpsm1bENSDARG00000054874Danio rerio
 GPSM1ENSGALG00000001797Gallus gallus
 GPSM1ENSG00000160360Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpsm2 / Q8VDU0 / G-protein-signaling modulator 2 / P81274*ENSMUSG0000002788355
Ttc28 / Q80XJ3 / tetratricopeptide repeat domain 28 / Q96AY4*ENSMUSG0000003320928
Pcp2 / P12660 / Purkinje cell protein 2 / Q8IVA1*ENSMUSG000000046306


Protein motifs (from Interpro)
Interpro ID Name
 IPR003109  GoLoco motif
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0016239 positive regulation of macroautophagy ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0034260 negative regulation of GTPase activity ISO
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:1905098 negative regulation of guanyl-nucleotide exchange factor activity ISO
 cellular_componentGO:0000139 Golgi membrane ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005938 cell cortex ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005092 GDP-dissociation inhibitor activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030695 GTPase regulator activity IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpsm1tm1.1Lajb/Gpsm1tm1.1Lajb,Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Gpsm1tm1.1Lajb/Gpsm1tm1.1Lajb,Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gpsm1tm1.1Lajb/Gpsm1+,Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

 MP:0004184 abnormal baroreceptor physiology "anomaly in the function of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gpsm1tm1.1Lajb/Gpsm1tm1.1Lajb,Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpsm1tm1.1Lajb/Gpsm1tm1.1Lajb,Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gpsm1tm1.1Lajb/Gpsm1+,Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpsm1tm1.1Lajb/Gpsm1tm1.1Lajb,Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gpsm1tm1.1Lajb/Gpsm1+,Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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