ENSMUSG00000027883


Mus musculus

Features
Gene ID: ENSMUSG00000027883
  
Biological name :Gpsm2
  
Synonyms : G-protein-signaling modulator 2 / Gpsm2 / Q8VDU0
  
Possible biological names infered from orthology : P81274
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F3
Gene start: 108678638
Gene end: 108722309
  
Corresponding Affymetrix probe sets: 10501402 (MoGene1.0st)   1424895_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029482
Ensembl peptide - ENSMUSP00000115759
NCBI entrez gene - 76123     See in Manteia.
MGI - MGI:1923373
RefSeq - XM_006502256
RefSeq - NM_029522
RefSeq Peptide - NP_083798
swissprot - Q3UPG3
swissprot - Q8VDU0
swissprot - A2AEL5
Ensembl - ENSMUSG00000027883
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpsm2ENSDARG00000017311Danio rerio
 gpsm2lENSDARG00000102026Danio rerio
 GPSM2ENSGALG00000002090Gallus gallus
 GPSM2ENSG00000121957Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpsm1 / Q6IR34 / Mus musculus G-protein signalling modulator 1 (AGS3-like, C. elegans) (Gpsm1), transcript variant 5, mRNA. / Q86YR5* / G protein signaling modulator 1*ENSMUSG0000002693058
Ttc28 / Q80XJ3 / tetratricopeptide repeat domain 28 / Q96AY4*ENSMUSG0000003320928
Pcp2 / P12660 / Purkinje cell protein 2 / Q8IVA1*ENSMUSG000000046305


Protein motifs (from Interpro)
Interpro ID Name
 IPR003109  GoLoco motif
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007052 mitotic spindle organization IEA
 biological_processGO:0031291 Ran protein signal transduction ISS
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051661 maintenance of centrosome location IEA
 biological_processGO:0060236 regulation of mitotic spindle organization IEA
 biological_processGO:1904778 positive regulation of protein localization to cell cortex IEA
 biological_processGO:1905832 positive regulation of spindle assembly IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0097431 mitotic spindle pole IEA
 cellular_componentGO:0097575 lateral cell cortex ISO
 cellular_componentGO:0099738 cell cortex region IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IPI
 molecular_functionGO:0005092 GDP-dissociation inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030695 GTPase regulator activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0070840 dynein complex binding IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002948 abnormal neuronal specification "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]
Show

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004532 abnormal inner hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004536 short inner hair cell stereocilia "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011060 abnormal kinocilium morphology "any structural anomaly of the nonmotile primary cilium that is found at the apical surface of auditory receptor cells" [GO:0060091]
Show

Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0020378 abnormal cell cytoskeleton morphology "any anomaly in the structure of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm" [GO:0005856, MGI:mberry]
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Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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