| MP:0000111 | cleft palate | "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
Show
Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
|
| MP:0000130 | abnormal cancellous bone morphology | "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0000150 | abnormal rib morphology | "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311] |
Show
Allelic Composition: Foxp3sf/?
Genetic Background: Not Specified
|
| MP:0000161 | scoliosis | "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943] |
Show
Allelic Composition: Foxp3sf/?
Genetic Background: Not Specified
|
| MP:0000221 | decreased WBC count | "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Lbrlym3/Lbrlym3
Genetic Background: C57BL/6-Lbrlym3
Allelic Composition: Lbric-J/Lbrlym3
Genetic Background: C57BL/6-Lbric-J/Lbrlym3
|
| MP:0000240 | extramedullary hematopoiesis | "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
|
| MP:0000367 | abnormal coat/ hair morphology | "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Lbric-J/Lbric-J
Genetic Background: C57BL/6J-Lbric-J
Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J
|
| MP:0000416 | sparse fur | "fur that is significantly less dense" [J:46854] |
Show
Allelic Composition: Zap70tm2.1Mmal/Zap70tm2.1Mmal,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * DBA/2
Allelic Composition: Lbric-J/Lbric-J
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0000422 | delayed hair appearance | "late onset of the first appearance of the fur" [J:17792] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0000564 | syndactyly | "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Zap70tm2.1Mmal/Zap70tm2.1Mmal,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * DBA/2
Allelic Composition: Lbric-J/Lbric-J
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
Show
Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Lbric-J/Lbric-J
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Opn4tm1Skay/Opn4tm1Skay,Pde6brd1/Pde6brd1
Genetic Background: B6.Cg-Pde6brd1 Opn4tm1Skay
|
| MP:0000694 | spleen hypoplasia | "small size due to reduced cell number in the spleen" [J:43971] |
Show
Allelic Composition: Lbrlym3/Lbrlym3
Genetic Background: C57BL/6-Lbrlym3
|
| MP:0000702 | enlarged lymph nodes | "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
|
| MP:0000716 | abnormal immune system cell morphology | "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Lbric-2J/Lbric-2J
Genetic Background: involves: A/J
Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J
|
| MP:0000717 | abnormal lymphocyte number | "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Lbrlym3/Lbrlym3
Genetic Background: C57BL/6-Lbrlym3
|
| MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0000825 | dilated lateral ventricles | "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857] |
Show
Allelic Composition: Lbric-J/Lbric-J
Genetic Background: C57BL/6J-Lbric-J
|
| MP:0000921 | demyelination | "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0001121 | uterine hypoplasia | "reduced size of the uterus due to decreased cell number" [J:45065] |
Show
Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
|
| MP:0001143 | constricted vaginal opening | "shrunken, narrowed external vaginal opening" [J:50844] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0001191 | abnormal skin condition | "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0001192 | scaly skin | "skin covered with shedding scales or flakes" [J:65146] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
Allelic Composition: Lbric-J/Lbric-J
Genetic Background: C57BL/6J-Lbric-J
Allelic Composition: Lbric-J/Lbric-J
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0001216 | abnormal epidermal layer morphology | "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
Allelic Composition: Lbric-2J/Lbric-2J
Genetic Background: involves: A/J
Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J
|
| MP:0001222 | epidermal hyperplasia | "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
Show
Allelic Composition: Zap70tm2.1Mmal/Zap70tm2.1Mmal,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * DBA/2
|
| MP:0001239 | abnormal granular layer morphology | "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0001240 | abnormal cornified layer morphology | "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0001242 | hyperkeratosis | "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133] |
Show
Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
|
| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
Show
Allelic Composition: Zap70tm2.1Mmal/Zap70tm2.1Mmal,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * DBA/2
Allelic Composition: Lbric-2J/Lbric-2J
Genetic Background: involves: A/J
Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J
|
| MP:0001282 | short vibrissae | "decreased length of the vibrissae" [J:30249] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
Show
Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Lbric-J/Lbric-J
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0001764 | abnormal homeostasis | "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0001823 | thymus hypoplasia | "small size due to reduced cell number in the thymus" [J:23255] |
Show
Allelic Composition: Tnni3tm1Jdp/Tnni3tm1Jdp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0001891 | hydroencephaly | "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
Show
Allelic Composition: Lbric-J/Lbric-J
Genetic Background: C57BL/6J-Lbric-J
|
| MP:0001922 | reduced male fertility | "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0001923 | reduced female fertility | "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
Show
Allelic Composition: Foxp3sf/?
Genetic Background: Not Specified
|
| MP:0001926 | female infertility | "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193] |
Show
Allelic Composition: Foxp3sf/?
Genetic Background: Not Specified
|
| MP:0001943 | abnormal respiration | "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0002073 | abnormal hair growth | "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0002080 | prenatal lethality | "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Lbric-2J/Lbric-2J
Genetic Background: involves: A/J
Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J
|
| MP:0002081 | perinatal lethality | "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Lbric-2J/Lbric-2J
Genetic Background: involves: A/J
Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J
|
| MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Foxp3sf/?
Genetic Background: Not Specified
|
| MP:0002098 | abnormal vibrissae morphology | "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0002113 | abnormal skeleton development | "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Opn4tm1Skay/Opn4tm1Skay,Pde6brd1/Pde6brd1
Genetic Background: B6.Cg-Pde6brd1 Opn4tm1Skay
|
| MP:0002183 | gliosis | "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
|
| MP:0002286 | cryptorchism | "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0002415 | abnormal neutrophil morphology/development | "anomalous structure, differentiation, or number of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Lbric-J/Lbric-J
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0002429 | abnormal blood cell morphology/development | "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Lbric-2J/Lbric-2J
Genetic Background: involves: A/J
Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J
Allelic Composition: Lbrlym3/Lbrlym3
Genetic Background: C57BL/6-Lbrlym3
|
| MP:0002441 | abnormal granulocyte morphology/development | "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J
Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
|
| MP:0002444 | abnormal T cell physiology | "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Lbrlym3/Lbrlym3
Genetic Background: C57BL/6-Lbrlym3
|
| MP:0002459 | abnormal B cell physiology | "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Tnni3tm1Jdp/Tnni3tm1Jdp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0002619 | abnormal lymphocyte morphology/development | "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Lbric-J/Lbric-J
Genetic Background: C57BL/6J-Lbric-J
Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
Allelic Composition: Lbrlym3/Lbrlym3
Genetic Background: C57BL/6-Lbrlym3
|
| MP:0003055 | abnormal epiphyseal plate morphology | "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
Show
Allelic Composition: Lbric-J/Lbric-J
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0003111 | abnormal nucleus morphology | "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
Allelic Composition: Lbric/Lbr+
Genetic Background: Not Specified
Allelic Composition: Lbric-J/Lbric-J
Genetic Background: C57BL/6J-Lbric-J
Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
|
| MP:0003203 | increased neuron apoptosis | "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
|
| MP:0003215 | renal interstitial fibrosis | "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1
|
| MP:0003409 | decreased width of hypertrophic chondrocyte zone | "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0003632 | abnormal nervous system morphology | |
Show
Allelic Composition: Lbric-2J/Lbric-2J
Genetic Background: involves: A/J
Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J
|
| MP:0003662 | abnormal proliferative zone | "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254] |
Show
Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0003725 | increased autoantibody level | "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator] |
Show
Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1
|
| MP:0003853 | dry skin | "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Lbric-J/Lbric-J
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0004794 | increased anti-nuclear antigen antibody level | "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1
|
| MP:0004801 | increased susceptibility to systemic lupus erythematosus | "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1
|
| MP:0004829 | increased anti-chromatin antibody level | "increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1
|
| MP:0005016 | decreased lymphocyte number | "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Lbrlym3/Lbrlym3
Genetic Background: C57BL/6-Lbrlym3
Allelic Composition: Lbric-J/Lbrlym3
Genetic Background: C57BL/6-Lbric-J/Lbrlym3
|
| MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lbrlym3/Lbrlym3
Genetic Background: C57BL/6-Lbrlym3
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| MP:0005018 | decreased T cell number | "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lbrlym3/Lbrlym3
Genetic Background: C57BL/6-Lbrlym3
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| MP:0005061 | abnormal eosinophil morphology | "structural anomaly of the granular leukocytes having a two-lobed nucleus and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lbric-J/Lbric-J
Genetic Background: C57BL/6J-Lbric-J
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| MP:0005065 | abnormal neutrophil morphology | "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lbric-J/Lbric-J
Genetic Background: C57BL/6J-Lbric-J
Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
Allelic Composition: Lbrlym3/Lbrlym3
Genetic Background: C57BL/6-Lbrlym3
Allelic Composition: Lbrlym3/Lbr+
Genetic Background: C57BL/6-Lbrlym3
Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1
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| MP:0005095 | decreased T cell proliferation | "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Lbrlym3/Lbrlym3
Genetic Background: C57BL/6-Lbrlym3
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| MP:0005253 | abnormal eye physiology | "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
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| MP:0005264 | glomerulosclerosis | "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1
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| MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lbric-J/Lbr+
Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1
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| MP:0006038 | increased mitochondrial proliferation | "greater than normal reproduction of mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
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| MP:0008075 | decreased CD4-positive T cell number | "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lbrlym3/Lbrlym3
Genetic Background: C57BL/6-Lbrlym3
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| MP:0008079 | decreased CD8-positive T cell number | "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lbrlym3/Lbrlym3
Genetic Background: C57BL/6-Lbrlym3
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| MP:0008101 | lymph node hypoplasia | "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lbrlym3/Lbrlym3
Genetic Background: C57BL/6-Lbrlym3
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| MP:0008111 | abnormal granulocyte differentiaton | "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
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| MP:0008535 | enlarged lateral ventricles | "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
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| MP:0008730 | fused phalanges | "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
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| MP:0008844 | decreased subcutaneous adipose tissue amount | "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
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| MP:0008890 | abnormal nuclear lamina morphology | "alteration in the structure of the inner nuclear membrane surrounding the nuclear periphery, comprising a scaffold-like network of protein filaments responsible for trafficking of mRNA to the cytoplasm" [https://npd.hgu.mrc.ac.uk/compartments.html, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
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| MP:0009606 | increased keratohyalin granule size | "increased number of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
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| MP:0009611 | epidermis stratum spinosum hyperplasia | "overdevelopment or increased size, usually due an increased number of cells, of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
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| MP:0009675 | orthokeratosis | "thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lbric-J/Lbric-J
Genetic Background: C57BL/6J-Lbric-J
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Lbric-J/Lbr+,Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
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| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Lbric-J/Lbric-J
Genetic Background: C57BL/6J-Lbric-J
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Lbric-J/Lbric-J
Genetic Background: C57BL/6J-Lbric-J
Allelic Composition: LbrGt(XE569)Byg/LbrGt(XE569)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr
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| MP:0013178 | tail necrosis | "morphological changes resulting from pathological death of tail tissue; usually due to irreversible damage" [MGI:anna] |
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Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
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| MP:0020351 | decreased vocalization | "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702] |
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Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
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| MP:0030571 | dilated piliary canal | "stretched or widened aperture of the luminal space of the tubular connection that is found between the epidermal surface and the most distal part of the hair follicle inner root sheath and contains the hair shaft; the infundibulum is the opening of the hair canal to the skin surface" [MGI:anna, PMID:11171393] |
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Allelic Composition: Lbric-J/Lbric-J
Genetic Background: C57BL/6J-Lbric-J
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