ENSMUSG00000004891


Mus musculus

Features
Gene ID: ENSMUSG00000004891
  
Biological name :Nes
  
Synonyms : Nes / Nestin / Q6P5H2
  
Possible biological names infered from orthology : P48681
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 87971078
Gene end: 87980451
  
Corresponding Affymetrix probe sets: 10493114 (MoGene1.0st)   1418289_at (Mouse Genome 430 2.0 Array)   1449022_at (Mouse Genome 430 2.0 Array)   1453997_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000088493
Ensembl peptide - ENSMUSP00000125571
NCBI entrez gene - 18008     See in Manteia.
MGI - MGI:101784
RefSeq - NM_016701
RefSeq Peptide - NP_057910
swissprot - Q6P5H2
Ensembl - ENSMUSG00000004891
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NESENSG00000132688Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Synm / Q70IV5 / synemin, intermediate filament protein / O15061* / synemin*ENSMUSG0000003055414


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR018039  Intermediate filament protein, conserved site
 IPR031211  Nestin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007420 brain development ISS
 biological_processGO:0030844 positive regulation of intermediate filament depolymerization ISS
 biological_processGO:0031076 embryonic camera-type eye development ISS
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0048858 cell projection morphogenesis IMP
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005882 intermediate filament IDA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019215 intermediate filament binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Stc2tm1Gthi/Stc2tm1Gthi
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Stc2tm1Gthi/Stc2tm1Gthi
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Rps28GT(RNA3)Whk/Rps28GT(RNA3)Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps28GT(RNA3)Whk/Rps28GT(RNA3)Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rps28GT(RNA3)Whk/Rps28GT(RNA3)Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rps28GT(RNA3)Whk/Rps28GT(RNA3)Whk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Nestm1Dopa/Nestm1Dopa,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
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Allelic Composition: Rps28GT(RNA3)Whk/Rps28GT(RNA3)Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011105 partial embryonic lethality between implantation and placentation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Rps28GT(RNA3)Whk/Rps28GT(RNA3)Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Rps28GT(RNA3)Whk/Rps28GT(RNA3)Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Kcnh3tm1.1(KOMP)Vlcg/Kcnh3+
Genetic Background: C57BL/6N-Kcnh3tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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