ENSMUSG00000030554


Mus musculus

Features
Gene ID: ENSMUSG00000030554
  
Biological name :Synm
  
Synonyms : Q70IV5 / synemin, intermediate filament protein / Synm
  
Possible biological names infered from orthology : O15061 / synemin
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: C
Gene start: 67730160
Gene end: 67759742
  
Corresponding Affymetrix probe sets: 10564482 (MoGene1.0st)   1455610_at (Mouse Genome 430 2.0 Array)   1457275_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073855
Ensembl peptide - ENSMUSP00000147111
Ensembl peptide - ENSMUSP00000147089
Ensembl peptide - ENSMUSP00000146510
Ensembl peptide - ENSMUSP00000050987
NCBI entrez gene - 233335     See in Manteia.
MGI - MGI:2661187
RefSeq - NM_183312
RefSeq - NM_201639
RefSeq - NM_207663
RefSeq Peptide - NP_964001
RefSeq Peptide - NP_997546
RefSeq Peptide - NP_899135
swissprot - Q70IV5
swissprot - A0A140LJ61
swissprot - A0A140LHQ9
swissprot - A0A140LJ79
Ensembl - ENSMUSG00000030554
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 synmENSDARG00000062350Danio rerio
 SYNMENSGALG00000007048Gallus gallus
 SYNMENSG00000182253Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nes / Q6P5H2 / Nestin / P48681*ENSMUSG0000000489116


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR018039  Intermediate filament protein, conserved site
 IPR030634  Synemin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031443 fast-twitch skeletal muscle fiber contraction IMP
 biological_processGO:0045104 intermediate filament cytoskeleton organization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0005912 adherens junction ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030018 Z disc ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0043034 costamere ISO
 cellular_componentGO:0060053 neurofilament cytoskeleton IDA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008307 structural constituent of muscle IEA
 molecular_functionGO:0017166 vinculin binding ISS
 molecular_functionGO:0019215 intermediate filament binding IDA
 molecular_functionGO:0030674 protein binding, bridging ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Klf2tm1Hhn/Klf2tm1Hhn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
Show

Allelic Composition: Sufutm1b(KOMP)Wtsi/Sufutm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Sufutm1b(KOMP)Wtsi/Ucd

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf2tm1Hhn/Klf2tm1Hhn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf2tm1Hhn/Klf2tm1Hhn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003646 muscle fatigue "increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306]
Show

Allelic Composition: Klf2tm1Hhn/Klf2tm1Hhn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003852 skeletal muscle necrosis "pathological cell death in the skeletal muscle, usually due to irreversible damage" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Klf2tm1Hhn/Klf2tm1Hhn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf2tm1Hhn/Klf2tm1Hhn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004121 abnormal sarcolemma morphology "structural anomaly in the plasma membrane of a muscle fiber that is cabable of conducting electrical impuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Klf2tm1Hhn/Klf2tm1Hhn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klf2tm1Hhn/Klf2tm1Hhn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009046 muscle twitch "minor, sometimes imperceptible, local muscle contractions or uncontrollable movement of a single muscle group served by a single motor nerve fiber or filament sometime, but not always, indicating a neurological disorder" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klf2tm1Hhn/Klf2tm1Hhn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010240 decreased skeletal muscle size "less than average dimensions of one or more of the muscles of the skeleton" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klf2tm1Hhn/Klf2tm1Hhn
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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