ENSMUSG00000005232


Mus musculus

Features
Gene ID: ENSMUSG00000005232
  
Biological name :G6pc2
  
Synonyms : G6pc2 / Glucose-6-phosphatase 2 / Q9Z186
  
Possible biological names infered from orthology : glucose-6-phosphatase catalytic subunit 2 / Q9NQR9
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C2
Gene start: 69211073
Gene end: 69227841
  
Corresponding Affymetrix probe sets: 10472531 (MoGene1.0st)   1423529_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005364
Ensembl peptide - ENSMUSP00000107936
NCBI entrez gene - 14378     See in Manteia.
MGI - MGI:1277193
RefSeq - NM_001289857
RefSeq - NM_001289856
RefSeq - NM_021331
RefSeq Peptide - NP_001276785
RefSeq Peptide - NP_001276786
RefSeq Peptide - NP_067306
swissprot - Q9Z186
Ensembl - ENSMUSG00000005232
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 G6PC2ENSGALG00000010899Gallus gallus
 G6PC2ENSG00000152254Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
G6pc / P35576 / Glucose-6-phosphatase / P35575* / glucose-6-phosphatase catalytic subunit*ENSMUSG0000007865049
G6pc3 / Q6NSQ9 / Glucose-6-phosphatase 3 / Q9BUM1* / glucose-6-phosphatase catalytic subunit 3*ENSMUSG0000003479332


Protein motifs (from Interpro)
Interpro ID Name
 IPR000326  Phosphatidic acid phosphatase type 2/haloperoxidase
 IPR016275  Glucose-6-phosphatase
 IPR036938  Phosphatidic acid phosphatase type 2/haloperoxidase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006094 gluconeogenesis IBA
 biological_processGO:0042593 glucose homeostasis ISO
 biological_processGO:0050796 regulation of insulin secretion ISO
 biological_processGO:0051156 glucose 6-phosphate metabolic process IBA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IBA
 molecular_functionGO:0004346 glucose-6-phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Gluconeogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1+
Genetic Background: Not Specified

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mogtm1Dpd/Mogtm1Dpd,Rag2tm1Cgn/Rag2tm1Cgn,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mogtm1Dpd/Mogtm1Dpd,Rag2tm1Cgn/Rag2tm1Cgn,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Mogtm1Dpd/Mogtm1Dpd,Rag2tm1Cgn/Rag2tm1Cgn,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1+
Genetic Background: Not Specified

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Mogtm1Dpd/Mogtm1Dpd,Rag2tm1Cgn/Rag2tm1Cgn,Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr