ENSMUSG00000078650


Mus musculus

Features
Gene ID: ENSMUSG00000078650
  
Biological name :G6pc
  
Synonyms : G6pc / Glucose-6-phosphatase / P35576
  
Possible biological names infered from orthology : glucose-6-phosphatase catalytic subunit / P35575
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 101367561
Gene end: 101377903
  
Corresponding Affymetrix probe sets: 10381387 (MoGene1.0st)   1417880_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019469
NCBI entrez gene - 14377     See in Manteia.
MGI - MGI:95607
RefSeq - NM_008061
RefSeq Peptide - NP_032087
swissprot - P35576
Ensembl - ENSMUSG00000078650
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 g6pca.1ENSDARG00000031616Danio rerio
 g6pca.2ENSDARG00000013721Danio rerio
 g6pcbENSDARG00000014967Danio rerio
 G6PCENSGALG00000030034Gallus gallus
 G6PCENSG00000131482Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
G6pc2 / Q9Z186 / Glucose-6-phosphatase 2 / Q9NQR9* / glucose-6-phosphatase catalytic subunit 2*ENSMUSG0000000523248
G6pc3 / Q6NSQ9 / Glucose-6-phosphatase 3 / Q9BUM1* / glucose-6-phosphatase catalytic subunit 3*ENSMUSG0000003479334


Protein motifs (from Interpro)
Interpro ID Name
 IPR000326  Phosphatidic acid phosphatase type 2/haloperoxidase
 IPR016275  Glucose-6-phosphatase
 IPR036938  Phosphatidic acid phosphatase type 2/haloperoxidase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005977 glycogen metabolic process IMP
 biological_processGO:0005980 glycogen catabolic process IMP
 biological_processGO:0006094 gluconeogenesis ISO
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0006796 phosphate-containing compound metabolic process IEA
 biological_processGO:0008202 steroid metabolic process IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0015760 glucose-6-phosphate transport IMP
 biological_processGO:0032094 response to food IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0046415 urate metabolic process IMP
 biological_processGO:0046838 phosphorylated carbohydrate dephosphorylation IEA
 biological_processGO:0051156 glucose 6-phosphate metabolic process IMP
 biological_processGO:0055088 lipid homeostasis IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IBA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004346 glucose-6-phosphatase activity ISO
 molecular_functionGO:0016773 phosphotransferase activity, alcohol group as acceptor IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042301 phosphate ion binding IEA


Pathways (from Reactome)
Pathway description
Gluconeogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: G6pctm2.2Jyc/G6pctm2.2Jyc
Genetic Background: involves:129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tph2tm2.1Pasq/Tph2tm2.2Pasq,Tg(CMV-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bub1tm3.1Jvd/Bub1tm3.1Jvd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: G6pctm2.2Jyc/G6pctm2.2Jyc
Genetic Background: involves:129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: G6pctm2.2Jyc/G6pctm2.2Jyc
Genetic Background: involves:129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: G6pctm2.2Jyc/G6pctm2.2Jyc
Genetic Background: involves:129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tph2tm2.1Pasq/Tph2tm2.2Pasq,Tg(CMV-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csf1op/Csf1op
Genetic Background: B6;C3Fe a/a-Csf1op/J

Allelic Composition: G6pctm2.1Jyc/G6pctm2.1Jyc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tph2tm2.1Pasq/Tph2tm2.2Pasq,Tg(CMV-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002901 hyperphosphaturia "an increase of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002959 increased microalbumin excretion "greater than the normal amount of fragments of this protein voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: G6pctm2.2Jyc/G6pctm2.2Jyc
Genetic Background: involves:129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: G6pctm2.2Jyc/G6pctm2.2Jyc
Genetic Background: involves:129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: G6pctm2.2Jyc/G6pctm2.2Jyc
Genetic Background: involves:129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Tph2tm2.1Pasq/Tph2tm2.2Pasq,Tg(CMV-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005440 increased glycogen level "greater than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: G6pctm2.2Jyc/G6pctm2.2Jyc
Genetic Background: involves:129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008821 increased blood uric acid level "greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: G6pctm2.2Jyc/G6pctm2.2Jyc
Genetic Background: involves:129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0009350 decreased urine pH "increased urine acidity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: G6pctm2.2Jyc/G6pctm2.2Jyc
Genetic Background: involves:129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0009810 increased urine uric acid level "greater concentration in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011363 renal glomerulus atrophy "acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Col2a1tm1Prc/Col2a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011435 increased urine magnesium level "higher than normal amount of magnesium in the urine" [MGI:anna]
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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