ENSMUSG00000034793


Mus musculus

Features
Gene ID: ENSMUSG00000034793
  
Biological name :G6pc3
  
Synonyms : G6pc3 / Glucose-6-phosphatase 3 / Q6NSQ9
  
Possible biological names infered from orthology : glucose-6-phosphatase catalytic subunit 3 / Q9BUM1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 102189620
Gene end: 102194081
  
Corresponding Affymetrix probe sets: 10381539 (MoGene1.0st)   1428245_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064276
Ensembl peptide - ENSMUSP00000077995
NCBI entrez gene - 68401     See in Manteia.
MGI - MGI:1915651
RefSeq - NM_175935
RefSeq Peptide - NP_787949
swissprot - Q6NSQ9
Ensembl - ENSMUSG00000034793
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 g6pc3ENSDARG00000020371Danio rerio
 G6PC3ENSG00000141349Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
G6pc / P35576 / Glucose-6-phosphatase / P35575* / glucose-6-phosphatase catalytic subunit*ENSMUSG0000007865035
G6pc2 / Q9Z186 / Glucose-6-phosphatase 2 / Q9NQR9* / glucose-6-phosphatase catalytic subunit 2*ENSMUSG0000000523233


Protein motifs (from Interpro)
Interpro ID Name
 IPR000326  Phosphatidic acid phosphatase type 2/haloperoxidase
 IPR016275  Glucose-6-phosphatase
 IPR036938  Phosphatidic acid phosphatase type 2/haloperoxidase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006094 gluconeogenesis IBA
 biological_processGO:0006796 phosphate-containing compound metabolic process IEA
 biological_processGO:0015760 glucose-6-phosphate transport IGI
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0051156 glucose 6-phosphate metabolic process IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IBA
 molecular_functionGO:0004346 glucose-6-phosphatase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Gluconeogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc16a2tm1Dgen/Y
Genetic Background: either: (involves: C57BL/6N) or (involves: NMRI)

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc16a2tm1Dgen/Y
Genetic Background: either: (involves: C57BL/6N) or (involves: NMRI)

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc16a2tm1Dgen/Y
Genetic Background: either: (involves: C57BL/6N) or (involves: NMRI)

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc16a2tm1Dgen/Y
Genetic Background: either: (involves: C57BL/6N) or (involves: NMRI)

 MP:0002712 increased circulating glucagon level "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

 MP:0005074 defective granulocyte bactericidal activity "inability or reduced ability of neutrophils, eosinophils, or basophils to kill bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5405]
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Allelic Composition: Slc16a2tm1Dgen/Y
Genetic Background: either: (involves: C57BL/6N) or (involves: NMRI)

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc16a2tm1Dgen/Y
Genetic Background: either: (involves: C57BL/6N) or (involves: NMRI)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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