Manteia

ENSMUSG00000005312

Mus musculus

Features

Gene ID:	ENSMUSG00000005312

Biological name :	Ubqln1

Synonyms :	Q8R317 / ubiquilin 1 / Ubqln1

Possible biological names infered from orthology :	Q9UMX0

Species:	Mus musculus

Chr. number:	13
Strand:	-1
Band:	B1
Gene start:	58176156
Gene end:	58215653

Corresponding Affymetrix probe sets:	10409645 (MoGene1.0st) 1419385_a_at (Mouse Genome 430 2.0 Array) 1424368_s_at (Mouse Genome 430 2.0 Array) 1450345_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000153666 Ensembl peptide - ENSMUSP00000050191 Ensembl peptide - ENSMUSP00000075782 NCBI entrez gene - 56085 See in Manteia. MGI - MGI:1860276 RefSeq - NM_026842 RefSeq - NM_152234 RefSeq Peptide - NP_081118 RefSeq Peptide - NP_689420 swissprot - A0A286YE09 swissprot - Q8R317 Ensembl - ENSMUSG00000005312

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
	ENSGALG00000012585	Gallus gallus
Q9UMX0	ENSG00000135018	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q9QZM0 / Ubqln2 / ubiquilin 2 / Q9UHD9*	ENSMUSG00000050148	75
Q99NB8 / Ubqln4 / ubiquilin 4 / Q9NRR5*	ENSMUSG00000008604	61
Q8C5U9 / Ubqln3 / ubiquilin 3 / Q9H347*	ENSMUSG00000051618	46
Q14DL0 / Ubqlnl / ubiquilin-like / Q8IYU4*	ENSMUSG00000051437	35
Ubqln5 / ubiquilin 5	ENSMUSG00000055643	29

Protein motifs (from Interpro)

Interpro ID	Name
IPR000626	Ubiquitin domain
IPR006636	Heat shock chaperonin-binding
IPR009060	UBA-like superfamily
IPR015496	Ubiquilin
IPR015940	Ubiquitin-associated domain
IPR028799	Ubiquilin-1
IPR029071	Ubiquitin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000045	autophagosome assembly	ISO
biological_process	GO:0006914	autophagy	IEA
biological_process	GO:0016236	macroautophagy	ISO
biological_process	GO:0030433	ubiquitin-dependent ERAD pathway	ISS
biological_process	GO:0031396	regulation of protein ubiquitination	ISS
biological_process	GO:0031398	positive regulation of protein ubiquitination	ISO
biological_process	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	IMP
biological_process	GO:0034976	response to endoplasmic reticulum stress	ISO
biological_process	GO:0035973	aggrephagy	ISO
biological_process	GO:0071456	cellular response to hypoxia	ISS
biological_process	GO:0097352	autophagosome maturation	ISO
biological_process	GO:1901340	negative regulation of store-operated calcium channel activity	ISO
biological_process	GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISS
biological_process	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process	ISS
cellular_component	GO:0000502	proteasome complex	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005776	autophagosome	ISO
cellular_component	GO:0005783	endoplasmic reticulum	ISS
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016235	aggresome	ISS
cellular_component	GO:0031410	cytoplasmic vesicle	IEA
cellular_component	GO:0032991	protein-containing complex	IEA
cellular_component	GO:0048471	perinuclear region of cytoplasm	ISS
molecular_function	GO:0005102	signaling receptor binding	NAS
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0019215	intermediate filament binding	NAS
molecular_function	GO:0019900	kinase binding	ISS
molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	ISS
molecular_function	GO:0042802	identical protein binding	ISO

Pathways (from Reactome)

Pathway description

Cargo recognition for clathrin-mediated endocytosis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Pdlim7^{Gt(OST445990)Lex}/Pdlim7^{Gt(OST445990)Lex} Genetic Background: B6.129S5-Pdlim7^{Gt(OST445990)Lex}
MP:0003075	response to CNS ischemic injury		Show Allelic Composition: Pdlim7^{Gt(OST445990)Lex}/Pdlim7^{Gt(OST445990)Lex} Genetic Background: B6.129S5-Pdlim7^{Gt(OST445990)Lex}
MP:0006060	increased cerebral infarction size	"increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pdlim7^{Gt(OST445990)Lex}/Pdlim7^{Gt(OST445990)Lex} Genetic Background: B6.129S5-Pdlim7^{Gt(OST445990)Lex}

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr