ENSMUSG00000005609


Mus musculus

Features
Gene ID: ENSMUSG00000005609
  
Biological name :Ctr9
  
Synonyms : Ctr9 / Q62018 / RNA polymerase-associated
  
Possible biological names infered from orthology : CTR9 homolog, Paf1/RNA polymerase II complex component / Q6PD62
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E3
Gene start: 111028951
Gene end: 111056377
  
Corresponding Affymetrix probe sets: 10556321 (MoGene1.0st)   1422679_s_at (Mouse Genome 430 2.0 Array)   1422680_at (Mouse Genome 430 2.0 Array)   1422681_at (Mouse Genome 430 2.0 Array)   1442240_at (Mouse Genome 430 2.0 Array)   1448076_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005749
NCBI entrez gene - 22083     See in Manteia.
MGI - MGI:109345
RefSeq - NM_009431
RefSeq Peptide - NP_033457
swissprot - Q62018
Ensembl - ENSMUSG00000005609
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctr9ENSDARG00000009170Danio rerio
 CTR9ENSGALG00000005618Gallus gallus
 CTR9ENSG00000198730Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR027363  Methylthioribose-1-phosphate isomerase, N-terminal
 IPR031101  RNA polymerase-associated protein Ctr9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001711 endodermal cell fate commitment IMP
 biological_processGO:0001826 inner cell mass cell differentiation IMP
 biological_processGO:0001829 trophectodermal cell differentiation IMP
 biological_processGO:0001832 blastocyst growth IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007259 JAK-STAT cascade IMP
 biological_processGO:0010390 histone monoubiquitination IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016570 histone modification IEA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0033523 histone H2B ubiquitination IEA
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation IEA
 biological_processGO:0070102 interleukin-6-mediated signaling pathway IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0080182 histone H3-K4 trimethylation IEA
 biological_processGO:1900364 negative regulation of mRNA polyadenylation IEA
 biological_processGO:2000653 regulation of genetic imprinting IMP
 biological_processGO:2001162 positive regulation of histone H3-K79 methylation IEA
 biological_processGO:2001168 positive regulation of histone H2B ubiquitination IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016593 Cdc73/Paf1 complex IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0035327 transcriptionally active chromatin IDA
 molecular_functionGO:0000993 RNA polymerase II core binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042169 SH2 domain binding IDA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation
E3 ubiquitin ligases ubiquitinate target proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Cpsf3tm1b(EUCOMM)Wtsi/Cpsf3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cpsf3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0010851 decreased effector memory CD8-positive, alpha-beta T cell number "reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Cpsf3tm1b(EUCOMM)Wtsi/Cpsf3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cpsf3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cpsf3tm1b(EUCOMM)Wtsi/Cpsf3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cpsf3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Cpsf3tm1b(EUCOMM)Wtsi/Cpsf3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cpsf3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
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Allelic Composition: Cpsf3tm1b(EUCOMM)Wtsi/Cpsf3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cpsf3tm1b(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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