ENSMUSG00000005683


Mus musculus

Features
Gene ID: ENSMUSG00000005683
  
Biological name :Cs
  
Synonyms : Citrate synthase, mitochondrial / Cs / Q9CZU6
  
Possible biological names infered from orthology : citrate synthase / O75390
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 128337734
Gene end: 128362479
  
Corresponding Affymetrix probe sets: 10367292 (MoGene1.0st)   1422577_at (Mouse Genome 430 2.0 Array)   1422578_at (Mouse Genome 430 2.0 Array)   1450667_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005826
NCBI entrez gene - 12974     See in Manteia.
MGI - MGI:88529
RefSeq - NM_026444
RefSeq Peptide - NP_080720
swissprot - Q9CZU6
Ensembl - ENSMUSG00000005683
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 csENSDARG00000103364Danio rerio
 CSENSGALG00000030466Gallus gallus
 CSENSG00000062485Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Csl / citrate synthase like / CS* / O75390* / citrate synthase*ENSMUSG0000004693492


Protein motifs (from Interpro)
Interpro ID Name
 IPR002020  Citrate synthase
 IPR010109  Citrate synthase, eukaryotic-type
 IPR016142  Citrate synthase-like, large alpha subdomain
 IPR016143  Citrate synthase-like, small alpha subdomain
 IPR019810  Citrate synthase active site
 IPR036969  Citrate synthase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process ISO
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006101 citrate metabolic process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix ISO
 molecular_functionGO:0004108 citrate (Si)-synthase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer IDA


Pathways (from Reactome)
Pathway description
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Traddtm1.1Mpa/Traddtm1.1Mpa
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Traddtm1.1Mpa/Traddtm1.1Mpa
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cpsf3tm1b(EUCOMM)Wtsi/Cpsf3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cpsf3tm1b(EUCOMM)Wtsi/Wtsi

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Traddtm1.1Mpa/Traddtm1.1Mpa
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

Allelic Composition: Csahl4/Csahl4
Genetic Background: (A/J x B6.A-Csahl4)F1

Allelic Composition: Csahl4/Csahl4,mt-Trm1/mt-Trm1
Genetic Background: involves: A/J * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000046934 Csl / citrate synthase like / CS* / O75390* / citrate synthase*  / complex
 ENSMUSG00000005683 Cs / Q9CZU6 / Citrate synthase, mitochondrial / O75390* / citrate synthase*  / complex






 

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