ENSMUSG00000005899


Mus musculus

Features
Gene ID: ENSMUSG00000005899
  
Biological name :Smpd4
  
Synonyms : Q6ZPR5 / Smpd4 / sphingomyelin phosphodiesterase 4
  
Possible biological names infered from orthology : Q9NXE4
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A3
Gene start: 17619354
Gene end: 17644828
  
Corresponding Affymetrix probe sets: 10434067 (MoGene1.0st)   1429530_a_at (Mouse Genome 430 2.0 Array)   1429531_at (Mouse Genome 430 2.0 Array)   1437024_at (Mouse Genome 430 2.0 Array)   1453182_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006053
Ensembl peptide - ENSMUSP00000087620
Ensembl peptide - ENSMUSP00000130720
Ensembl peptide - ENSMUSP00000131867
NCBI entrez gene - 77626     See in Manteia.
MGI - MGI:1924876
RefSeq - XM_006522725
RefSeq - NM_001164609
RefSeq - NM_001164610
RefSeq - NM_001164611
RefSeq - NM_029945
RefSeq - XM_006522720
RefSeq - XM_006522721
RefSeq - XM_006522722
RefSeq Peptide - NP_001158081
RefSeq Peptide - NP_001158082
RefSeq Peptide - NP_001158083
RefSeq Peptide - NP_084221
swissprot - Q6ZPR5
Ensembl - ENSMUSG00000005899
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smpd4ENSDARG00000020730Danio rerio
 ENSGALG00000006455Gallus gallus
 SMPD4ENSG00000136699Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024129  Sphingomyelin phosphodiesterase 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006685 sphingomyelin catabolic process ISS
 biological_processGO:0046475 glycerophospholipid catabolic process ISO
 biological_processGO:0046513 ceramide biosynthetic process ISO
 biological_processGO:0071356 cellular response to tumor necrosis factor ISO
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005802 trans-Golgi network ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004767 sphingomyelin phosphodiesterase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050290 sphingomyelin phosphodiesterase D activity ISS


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Smotm1b(KOMP)Wtsi/Bay

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Smotm1b(KOMP)Wtsi/Bay

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Smotm1b(KOMP)Wtsi/Bay

 MP:0003586 ureter dilation "abnormal distention of the ureter due to accumulation of fluid" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Smotm1b(KOMP)Wtsi/Bay

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Smotm1b(KOMP)Wtsi/Bay

 MP:0011513 abnormal vertebral artery morphology "any structural anomaly of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [ISBN:0-683-40008-8]
Show

Allelic Composition: Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Smotm1b(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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