ENSMUSG00000006191


Mus musculus

Features
Gene ID: ENSMUSG00000006191
  
Biological name :Cdkal1
  
Synonyms : Cdkal1 / Q91WE6 / Threonylcarbamoyladenosine tRNA methylthiotransferase
  
Possible biological names infered from orthology : CDK5 regulatory subunit associated protein 1 like 1 / Q5VV42
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.2
Gene start: 29191746
Gene end: 29855674
  
Corresponding Affymetrix probe sets: 10408455 (MoGene1.0st)   1423953_at (Mouse Genome 430 2.0 Array)   1430039_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120432
Ensembl peptide - ENSMUSP00000122249
Ensembl peptide - ENSMUSP00000121792
Ensembl peptide - ENSMUSP00000006353
Ensembl peptide - ENSMUSP00000089262
Ensembl peptide - ENSMUSP00000105952
Ensembl peptide - ENSMUSP00000117404
Ensembl peptide - ENSMUSP00000118815
NCBI entrez gene - 68916     See in Manteia.
MGI - MGI:1921765
RefSeq - XM_017315589
RefSeq - NM_001308486
RefSeq - NM_144536
RefSeq - XM_011244342
RefSeq Peptide - NP_653119
RefSeq Peptide - NP_001295415
swissprot - B7FAT1
swissprot - Q91WE6
swissprot - F6S0I8
swissprot - I7HPB3
swissprot - D6RJ19
Ensembl - ENSMUSG00000006191
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01090785.1ENSDARG00000110572Danio rerio
 cdkal1ENSDARG00000104848Danio rerio
 CDKAL1ENSGALG00000012677Gallus gallus
 CDKAL1ENSG00000145996Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BTW8 / Cdk5rap1 / CDK5 regulatory subunit-associated protein 1 / Q96SZ6*ENSMUSG0000002748721


Protein motifs (from Interpro)
Interpro ID Name
 IPR002792  TRAM domain
 IPR005839  Methylthiotransferase
 IPR006466  MiaB-like tRNA modifying enzyme, archaeal-type
 IPR006638  Elp3/MiaB/NifB
 IPR007197  Radical SAM
 IPR013785  Aldolase-type TIM barrel
 IPR013848  Methylthiotransferase, N-terminal
 IPR020612  Methylthiotransferase, conserved site
 IPR023404  Radical SAM, alpha/beta horseshoe


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006400 tRNA modification IEA
 biological_processGO:0008033 tRNA processing IEA
 biological_processGO:0035600 tRNA methylthiolation IMP
 biological_processGO:1990145 maintenance of translational fidelity IMP
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035598 N6-threonylcarbomyladenosine methylthiotransferase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA
 molecular_functionGO:0061712 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Chattm1(cre)Lowl/Chat+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Chattm1(cre)Lowl/Chat+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Chattm1(cre)Lowl/Chat+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

Allelic Composition: Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/JNCrj

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Chattm1(cre)Lowl/Chat+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Chattm1(cre)Lowl/Chat+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Chattm1(cre)Lowl/Chat+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Mc4rtm1Lowl/Mc4rtm1Lowl,Chattm1(cre)Lowl/Chat+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/JNCrj

 MP:0009287 decreased abdominal fat pad weight "less than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/JNCrj

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/JNCrj

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/JNCrj

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
Show

Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/JNCrj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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