ENSMUSG00000027487


Mus musculus

Features
Gene ID: ENSMUSG00000027487
  
Biological name :Cdk5rap1
  
Synonyms : Cdk5rap1 / CDK5 regulatory subunit-associated protein 1 / Q8BTW8
  
Possible biological names infered from orthology : Q96SZ6
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H1
Gene start: 154335380
Gene end: 154373010
  
Corresponding Affymetrix probe sets: 10488748 (MoGene1.0st)   1448626_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028990
Ensembl peptide - ENSMUSP00000105352
Ensembl peptide - ENSMUSP00000105353
NCBI entrez gene - 66971     See in Manteia.
MGI - MGI:1914221
RefSeq - NM_025876
RefSeq Peptide - NP_080152
swissprot - Q3UW67
swissprot - Q8BTW8
Ensembl - ENSMUSG00000027487
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk5rap1ENSDARG00000044925Danio rerio
 CDK5RAP1ENSGALG00000006738Gallus gallus
 Q96SZ6ENSG00000101391Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdkal1 / Q91WE6 / Threonylcarbamoyladenosine tRNA methylthiotransferase / Q5VV42* / CDK5 regulatory subunit associated protein 1 like 1*ENSMUSG0000000619121


Protein motifs (from Interpro)
Interpro ID Name
 IPR002792  TRAM domain
 IPR005839  Methylthiotransferase
 IPR006463  tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase MiaB
 IPR006638  Elp3/MiaB/NifB
 IPR007197  Radical SAM
 IPR013848  Methylthiotransferase, N-terminal
 IPR020612  Methylthiotransferase, conserved site
 IPR023404  Radical SAM, alpha/beta horseshoe


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity ISS
 biological_processGO:0006400 tRNA modification IEA
 biological_processGO:0035600 tRNA methylthiolation IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity ISS
 biological_processGO:0045903 positive regulation of translational fidelity IGI
 biological_processGO:0070131 positive regulation of mitochondrial translation IMP
 biological_processGO:0070900 mitochondrial tRNA modification IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035597 N6-isopentenyladenosine methylthiotransferase activity IMP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0010959 abnormal oxidative phosphorylation "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0011638 abnormal mitochondrial chromosome morphology "any structrual anomaly of the chromosome found in the mitochondrion of a eukaryotic cell" [GO:0000262]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0012557 decreased calcium uptake by cardiac muscle "decreased directed movement of calcium ions into cardiac muscle; decreased or disrupted uptake may give rise to energetic deficit and oxidative stress. leading to cardiac disease" [http://orcid.org/0000-0001-5208-3432, PMID:22902320]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0013272 abnormal translation "any anomaly in the cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain; translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA; translation ends with the release of a polypeptide chain from the ribosome" [GO:0006412]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0014046 abnormal mitophagy "any anomaly in the autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions" [MGI:Anna, PMID:22743996]
Show

Allelic Composition: Epotm1.2Mym/Epotm1.2Mym,Tg(Epo*)458Mym/Tg(Epo*)458Mym
Genetic Background: involves: C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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