ENSMUSG00000006215


Mus musculus

Features
Gene ID: ENSMUSG00000006215
  
Biological name :Zbtb17
  
Synonyms : Q60821 / Zbtb17 / zinc finger and BTB domain containing 17
  
Possible biological names infered from orthology : Q13105
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 141444654
Gene end: 141467930
  
Corresponding Affymetrix probe sets: 10509998 (MoGene1.0st)   1416224_at (Mouse Genome 430 2.0 Array)   1443041_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006377
NCBI entrez gene - 22642     See in Manteia.
MGI - MGI:107410
RefSeq - NM_009541
RefSeq - XM_006538727
RefSeq Peptide - NP_033567
swissprot - Q60821
Ensembl - ENSMUSG00000006215
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zbtb17ENSDARG00000074548Danio rerio
 ZBTB17ENSGALG00000035352Gallus gallus
 Q13105ENSG00000116809Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80X44 / Zbtb24 / zinc finger and BTB domain containing 24 / O43167*ENSMUSG0000001982622
Q8K3J5 / Zfp131 / zinc finger protein 131 / P52739* / ZNF131*ENSMUSG0000009487019


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007398 ectoderm development IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001223 transcription coactivator binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4tm2Nnt/Il4tm2Nnt,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.Cg-Tgfb1tm1Doe Il4tm2Nnt

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Il4tm2Nnt/Il4tm2Nnt,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.Cg-Tgfb1tm1Doe Il4tm2Nnt

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000404 reduced curvature of zigzag hairs "smaller bending arch of the zigzag hairs" [J:62217]
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Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Zbtb17tm1Cksn/Zbtb17tm1Cksn,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6.Cg-Zbtb17tm1Cksn Cdkn1atm1Led Commd10Tg(Vav1-icre)A2Kio

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004381 abnormal hair follicle melanocyte morphology "any structural anomaly of the cells that produce pigment in the hair follicles" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0005409 darkened coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
Show

Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0008538 decreased zigzag hair amount "reduced number of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0010130 decreased DN1 thymic pro-T cell number "reduced number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]
Show

Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0010132 decreased DN2 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive" [CL:0000806]
Show

Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0010134 decreased DN3 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
Show

Allelic Composition: Notch1sot/Notch1sot
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1.1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0010202 focal dorsal hair loss "focal hair loss on the dorsal area of a rodent resulting in dorsal skin visible in a patch where hair loss occurs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:Sanger_Karp "Submission from Natasha Karp"]
Show

Allelic Composition: Zbtb17tm1Cksn/Zbtb17tm1Cksn,Krt14tm1(cre)Wbm/Krt14+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011198 absent proamniotic cavity "absence of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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