ENSMUSG00000006269


Mus musculus

Features
Gene ID: ENSMUSG00000006269
  
Biological name :Atp6v1b1
  
Synonyms : Atp6v1b1 / ATPase, H+ transporting, lysosomal V1 subunit B1
  
Possible biological names infered from orthology : ATPase H+ transporting V1 subunit B1 / P15313
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C3
Gene start: 83742990
Gene end: 83758855
  
Corresponding Affymetrix probe sets: 10539449 (MoGene1.0st)   1419373_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006431
Ensembl peptide - ENSMUSP00000146154
Ensembl peptide - ENSMUSP00000145710
NCBI entrez gene - 110935     See in Manteia.
MGI - MGI:103285
RefSeq - NM_134157
RefSeq Peptide - NP_598918
swissprot - A0A0U1RPW7
swissprot - A0A0U1RNU9
swissprot - Q91YH6
Ensembl - ENSMUSG00000006269
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P15313ENSG00000116039Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62814 / Atp6v1b2 / V-type proton ATPase subunit B, brain isoform / P21281* / ATPase H+ transporting V1 subunit B2*ENSMUSG0000000627383


Protein motifs (from Interpro)
Interpro ID Name
 IPR000194  ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
 IPR004100  ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
 IPR005723  ATPase, V1 complex, subunit B
 IPR020003  ATPase, alpha/beta subunit, nucleotide-binding domain, active site
 IPR022879  V-type ATP synthase regulatory subunit B/beta
 IPR024034  ATPase, F1/V1 complex, beta/alpha subunit, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification ISO
 biological_processGO:0006885 regulation of pH ISO
 biological_processGO:0007588 excretion ISO
 biological_processGO:0007605 sensory perception of sound ISO
 biological_processGO:0015991 ATP hydrolysis coupled proton transport IEA
 biological_processGO:0045851 pH reduction ISO
 biological_processGO:0046034 ATP metabolic process IEA
 biological_processGO:0055074 calcium ion homeostasis ISO
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0016328 lateral plasma membrane IDA
 cellular_componentGO:0016471 vacuolar proton-transporting V-type ATPase complex ISO
 cellular_componentGO:0033180 proton-transporting V-type ATPase, V1 domain IEA
 cellular_componentGO:0098850 extrinsic component of synaptic vesicle membrane IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015078 proton transmembrane transporter activity IMP


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Insulin receptor recycling
Transferrin endocytosis and recycling
Ion channel transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0000035 abnormal membranous labyrinth "malformations in the complex arrangement of communicating canaliculi and sacs suspended within the cavity of the bony labyrinth of the inner ear" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0001395 bi-directional circling "circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0001983 abnormal olfactory system physiology "abnormal function of the system relating to smell " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vps52tm1.1Kab/Vps52tm1.2Kab,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL * C57BL/6 * CBA * DBA

 MP:0002985 abnormal urine calcium level "any change in the level of excretion of calcium in the urine" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002986 hypocalciuria "excretion of abnormally low amounts of calcium in the urine" [J:83000]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

Allelic Composition: Atp6v1b1vtx/Atp6v1b1vtx
Genetic Background: B6.MRL-Atp6v1b1vtx/Kjn

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003017 decreased circulating bicarbonate level "reduced concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003031 acidosis "a pathological state characterized by an increase in the hydrogen ion concentration of arterial blood; caused by an decrease in the concentration of alkaline compounds, or by a increase in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003144 reduced number of otoliths "decreased average number of the crystalline calciferous particles adhering to the otolithic membrane" [J:30611, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0003462 abnormal response to novel odor "altered investigative behavior from controls in reactions associated with exposing an animal to a novel odor" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Vps52tm1.1Kab/Vps52tm1.2Kab,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL * C57BL/6 * CBA * DBA

 MP:0004043 abnormal pH regulation "anomaly in the function of the buffer systems of the body in combination with the respiratory and renal systems that control the relative acidity or alkalinity of the body, as measured by the concentration of hydrogen ion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vps52tm1.1Kab/Vps52tm1.2Kab,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL * C57BL/6 * CBA * DBA

 MP:0004287 abnormal spiral limbus morphology "any structural abnormality in the border of the spiral lamina, i.e. the thickened periosteum covering the upper plate of the bony spiral lamina of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0004292 abnormal spiral ligament fibrocyte morphology "any structural abnormality in the four types of fibrocytes (types I, II , III and IV) that constitute the spiral ligament" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0004293 abnormal type I spiral ligament fibrocytes "any structural abnormality of type I spiral ligament fibrocytes which occupy the region beneath the stria vascularis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0004295 abnormal type III spiral ligament fibrocytes "any structural abnormality of type III spiral ligament fibrocytes which form a cell layer attached to the otic capsule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0004411 decreased endocochlear potential "reduction of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0004862 small scala tympani "volume reduction of the division of the spiral canal of the cochlea lying on the basal side of the spiral lamina " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0004863 thin spiral ligament "reduced thickness of the periosteal lining of the bony cochlea that forms the outer wall of the cochlear duct to which the basal lamina attaches" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0006012 dilated endolymphatic duct "an expansion in the volume of the endolymphatic duct" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:67072:]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0006021 abnormal Reissner membrane morphology "any strutural alteration in Reissner s membrane which separates the cochlear duct from the vestibular canal, i.e. the endolymph of the scala media from the perilymph of the scala vestibuli; the Reissner membrane consists of squamous epithelial cells with microvilli toward the ductus, a basement membrane, and a thin layer of connective tissue toward the scala. " [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0006403 abnormal cochlear endolymph ionic homeostasis "anomaly in the state of equilibrium in the cochlear endolymph with respect to charged molecules; cochlear endolymph is not only an unusual extracellular fluid for its high potassium ion and low sodium ion concentration but also for its low calcium ion concentration, high HCO3- concentration and low protein content" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0008309 dilated scala media "stretched or widened aperture of the luminal space of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

 MP:0009349 increased urine pH "increased urine alkalinity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atp6v1b1vtx/Atp6v1b1vtx
Genetic Background: B6.MRL-Atp6v1b1vtx/Kjn

 MP:0011417 abnormal renal transport "any anomaly of the directed movement of substances through the kidney" [MGI:csmith]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Mybpc3tm2.1Lcrr/Mybpc3+
Genetic Background: involves: 129S2/SvPasCrl * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006269 Atp6v1b1 / ATPase, H+ transporting, lysosomal V1 subunit B1 / P15313* / ATPase H+ transporting V1 subunit B1*  / complex
 ENSMUSG00000006273 P62814 / Atp6v1b2 / V-type proton ATPase subunit B, brain isoform / P21281* / ATPase H+ transporting V1 subunit B2*  / complex






 

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