ENSMUSG00000006273


Mus musculus

Features
Gene ID: ENSMUSG00000006273
  
Biological name :Atp6v1b2
  
Synonyms : Atp6v1b2 / P62814 / V-type proton ATPase subunit B, brain isoform
  
Possible biological names infered from orthology : ATPase H+ transporting V1 subunit B2 / P21281
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 69088646
Gene end: 69113711
  
Corresponding Affymetrix probe sets: 10572146 (MoGene1.0st)   1415814_at (Mouse Genome 430 2.0 Array)   1419883_s_at (Mouse Genome 430 2.0 Array)   1446465_at (Mouse Genome 430 2.0 Array)   1449649_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006435
NCBI entrez gene - 11966     See in Manteia.
MGI - MGI:109618
RefSeq - NM_007509
RefSeq Peptide - NP_031535
swissprot - P62814
Ensembl - ENSMUSG00000006273
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp6v1b2ENSDARG00000043465Danio rerio
 ATP6V1B2ENSGALG00000033663Gallus gallus
 P21281ENSG00000147416Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp6v1b1 / ATPase, H+ transporting, lysosomal V1 subunit B1 / P15313* / ATPase H+ transporting V1 subunit B1*ENSMUSG0000000626984


Protein motifs (from Interpro)
Interpro ID Name
 IPR000194  ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
 IPR004100  ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
 IPR005723  ATPase, V1 complex, subunit B
 IPR020003  ATPase, alpha/beta subunit, nucleotide-binding domain, active site
 IPR022879  V-type ATP synthase regulatory subunit B/beta
 IPR024034  ATPase, F1/V1 complex, beta/alpha subunit, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0015991 ATP hydrolysis coupled proton transport IEA
 biological_processGO:0046034 ATP metabolic process IEA
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0033180 proton-transporting V-type ATPase, V1 domain IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Insulin receptor recycling
Transferrin endocytosis and recycling
Ion channel transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0002768 small adrenal glands "reduced size of endocrine glands located above the kidneys responsible for hormone and epinephrine secretion" [J:78062]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006269 Atp6v1b1 / ATPase, H+ transporting, lysosomal V1 subunit B1 / P15313* / ATPase H+ transporting V1 subunit B1*  / complex
 ENSMUSG00000006273 P62814 / Atp6v1b2 / V-type proton ATPase subunit B, brain isoform / P21281* / ATPase H+ transporting V1 subunit B2*  / complex






 

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