ENSMUSG00000006301


Mus musculus

Features
Gene ID: ENSMUSG00000006301
  
Biological name :Tmbim1
  
Synonyms : Tmbim1 / transmembrane BAX inhibitor motif containing 1
  
Possible biological names infered from orthology : Q969X1
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C3
Gene start: 74288247
Gene end: 74305622
  
Corresponding Affymetrix probe sets: 10355567 (MoGene1.0st)   1417162_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115444
Ensembl peptide - ENSMUSP00000122874
Ensembl peptide - ENSMUSP00000121814
Ensembl peptide - ENSMUSP00000016309
Ensembl peptide - ENSMUSP00000109427
NCBI entrez gene - 69660     See in Manteia.
MGI - MGI:1916910
RefSeq - NM_027154
RefSeq Peptide - NP_081430
swissprot - D3Z0A5
swissprot - F6YG30
swissprot - D3Z225
swissprot - Q3U717
Ensembl - ENSMUSG00000006301
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmbim1aENSDARG00000058323Danio rerio
 tmbim1bENSDARG00000109373Danio rerio
 TMBIM1ENSGALG00000011436Gallus gallus
 Q969X1ENSG00000135926Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Faim2 / Q8K097 / Protein lifeguard 2 / Q9BWQ8* / Fas apoptotic inhibitory molecule 2*ENSMUSG0000002301149
Grina / Q9ESF4 / Protein lifeguard 1 / Q7Z429* / glutamate ionotropic receptor NMDA type subunit associated protein 1*ENSMUSG0000002256441
Tmbim7 / transmembrane BAX inhibitor motif containing 7ENSMUSG0000001452930
Q9DA39 / Tmbim4 / transmembrane BAX inhibitor motif containing 4 / Q9HC24* / AC078927.1*ENSMUSG0000002022520


Protein motifs (from Interpro)
Interpro ID Name
 IPR006214  Bax inhibitor 1-related


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1902045 negative regulation of Fas signaling pathway IEA
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005123 death receptor binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnrhrhh/Gnrhrhh
Genetic Background: involves: C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnrhrhh/Gnrhrhh
Genetic Background: involves: C57BL/6

 MP:0009873 abnormal aorta tunica media morphology "any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gnrhrhh/Gnrhrhh
Genetic Background: involves: C57BL/6

 MP:0010574 aorta dilation "the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnrhrhh/Gnrhrhh
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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