ENSMUSG00000006345


Mus musculus

Features
Gene ID: ENSMUSG00000006345
  
Biological name :Ggt1
  
Synonyms : Ggt1 / Glutathione hydrolase 1 proenzyme Glutathione hydrolase 1 heavy chain Glutathione hydrolase 1 light chain / Q60928
  
Possible biological names infered from orthology : B5MD39 / gamma-glutamyltransferase 1 / gamma-glutamyltransferase 2 / gamma-glutamyltransferase light chain 1 / gamma-glutamyltransferase light chain 2 / gamma-glutamyltransferase light chain family member 3 / GGT2 / GGTLC1 / GGTLC2 / GGTLC3 / P19440 / P36268 / Q14390 / Q9BX51
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 75561604
Gene end: 75586200
  
Corresponding Affymetrix probe sets: 10364056 (MoGene1.0st)   1448485_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119844
Ensembl peptide - ENSMUSP00000117968
Ensembl peptide - ENSMUSP00000118261
Ensembl peptide - ENSMUSP00000118825
Ensembl peptide - ENSMUSP00000118852
Ensembl peptide - ENSMUSP00000118870
Ensembl peptide - ENSMUSP00000119387
Ensembl peptide - ENSMUSP00000120686
Ensembl peptide - ENSMUSP00000123017
Ensembl peptide - ENSMUSP00000122616
Ensembl peptide - ENSMUSP00000121774
Ensembl peptide - ENSMUSP00000121312
Ensembl peptide - ENSMUSP00000006508
Ensembl peptide - ENSMUSP00000115115
Ensembl peptide - ENSMUSP00000115118
Ensembl peptide - ENSMUSP00000115483
Ensembl peptide - ENSMUSP00000115818
Ensembl peptide - ENSMUSP00000117851
NCBI entrez gene - 14598     See in Manteia.
MGI - MGI:95706
RefSeq - XM_006513231
RefSeq - XM_006513230
RefSeq - XM_011243371
RefSeq - NM_008116
RefSeq - NM_001305992
RefSeq Peptide - NP_032142
RefSeq Peptide - NP_001292921
swissprot - D3Z2C6
swissprot - D3Z266
swissprot - D3YYH6
swissprot - F6V328
swissprot - F6WUX1
swissprot - D3YY79
swissprot - D3YXV6
swissprot - D3YWZ7
swissprot - D3YVX1
swissprot - D3YWW4
swissprot - Q4FK56
swissprot - Q60928
swissprot - D3YWW2
swissprot - D3YVY4
swissprot - D3Z4Q6
Ensembl - ENSMUSG00000006345
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU914631.1ENSDARG00000098576Danio rerio
 ggt1aENSDARG00000023526Danio rerio
 ggt1bENSDARG00000018342Danio rerio
 ggt1l2.1ENSDARG00000075055Danio rerio
 ggt1l2.2ENSDARG00000087054Danio rerio
 si:ch73-236c18.3ENSDARG00000075541Danio rerio
 si:ch73-59p9.2ENSDARG00000091254Danio rerio
 si:dkey-222h21.12ENSDARG00000092350Danio rerio
 ENSGALG00000006565Gallus gallus
 B5MD39ENSG00000274252Homo sapiens
 GGT1ENSG00000100031Homo sapiens
 GGT2ENSG00000133475Homo sapiens
 GGTLC1ENSG00000149435Homo sapiens
 GGTLC2ENSG00000100121Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ggt5 / Q9Z2A9 / Glutathione hydrolase 5 proenzyme Glutathione hydrolase 5 heavy chain Glutathione hydrolase 5 light chain / P36269* / gamma-glutamyltransferase 5*ENSMUSG0000000634440
Ggt7 / Q99JP7 / Glutathione hydrolase 7 Glutathione hydrolase 7 heavy chain Glutathione hydrolase 7 light chain / Q9UJ14* / gamma-glutamyltransferase 7*ENSMUSG0000002760330
Ggt6 / Q6PDE7 / Glutathione hydrolase 6 Glutathione hydrolase 6 heavy chain Glutathione hydrolase 6 light chain / Q6P531* / gamma-glutamyltransferase 6*ENSMUSG0000004047119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000101  Gamma-glutamyltranspeptidase
 IPR029055  Nucleophile aminohydrolases, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002682 regulation of immune system process IMP
 biological_processGO:0006412 translation IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006520 cellular amino acid metabolic process ISO
 biological_processGO:0006536 glutamate metabolic process ISO
 biological_processGO:0006631 fatty acid metabolic process ISO
 biological_processGO:0006749 glutathione metabolic process IEA
 biological_processGO:0006750 glutathione biosynthetic process IMP
 biological_processGO:0006751 glutathione catabolic process IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0019344 cysteine biosynthetic process IMP
 biological_processGO:0031638 zymogen activation ISS
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:1901750 leukotriene D4 biosynthetic process ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031982 vesicle IDA
 molecular_functionGO:0000048 peptidyltransferase activity ISO
 molecular_functionGO:0002951 leukotriene-C(4) hydrolase ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036374 glutathione hydrolase activity IEA
 molecular_functionGO:0102953 hypoglycin A gamma-glutamyl transpeptidase activity IEA
 molecular_functionGO:0103068 leukotriene C4 gamma-glutamyl transferase activity IEA


Pathways (from Reactome)
Pathway description
Glutathione synthesis and recycling
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Aflatoxin activation and detoxification


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ggt1enu1/Ggt1enu1
Genetic Background: C57BL/6J-Ggt1enu1

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: (STOCK Pou1f1dw x T(8;16)17H)F1

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ggt1enu1/Ggt1enu1
Genetic Background: C57BL/6J-Ggt1enu1

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ggt1enu1/Ggt1enu1
Genetic Background: C57BL/6J-Ggt1enu1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Ggt1enu1/Ggt1enu1
Genetic Background: C57BL/6J-Ggt1enu1

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: (STOCK Pou1f1dw x T(8;16)17H)F1

Allelic Composition: Ggt1tm1Zuk/Ggt1tm1Zuk,Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ggt1enu1/Ggt1enu1
Genetic Background: C57BL/6J-Ggt1enu1

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Ggt1enu1/Ggt1enu1
Genetic Background: C57BL/6J-Ggt1enu1

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ggt1enu1/Ggt1enu1
Genetic Background: C57BL/6J-Ggt1enu1

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ggt1tm1Zuk/Ggt1tm1Zuk,Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Ggt1tm1Zuk/Ggt1tm1Zuk,Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: (STOCK Pou1f1dw x T(8;16)17H)F1

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ggt1enu1/Ggt1enu1
Genetic Background: C57BL/6J-Ggt1enu1

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ggt1enu1/Ggt1enu1
Genetic Background: C57BL/6J-Ggt1enu1

 MP:0001937 abnormal sexual maturation "a delay or a block in the development of the sexual organs at a given age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ggt1tm1Zuk/Ggt1tm1Zuk,Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ggt1tm1Zuk/Ggt1tm1Zuk,Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ggt1tm1Zuk/Ggt1tm1Zuk,Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ggt1enu1/Ggt1enu1
Genetic Background: C57BL/6J-Ggt1enu1

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: (STOCK Pou1f1dw x T(8;16)17H)F1

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Esr1tm1Mma/Esr1tm1Mma
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003415 priapism "prolonged penile erection, often painful and without sexual desire " [smb:Susan M Bello, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ggt1enu1/Ggt1enu1
Genetic Background: C57BL/6J-Ggt1enu1

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

 MP:0003936 abnormal reproductive system development "developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: (STOCK Pou1f1dw x T(8;16)17H)F1

 MP:0004610 small vertebrae "reduced size of the bony segments of the spinal column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: (STOCK Pou1f1dw x T(8;16)17H)F1

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005471 decreased thyroxine level "less than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:13923]
Show

Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: (STOCK Pou1f1dw x T(8;16)17H)F1

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

 MP:0008477 decreased spleen red pulp amount "reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: (STOCK Pou1f1dw x T(8;16)17H)F1

 MP:0008912 nervous "increased, skittish, behavior induced by stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ggt1enu1/Ggt1enu1
Genetic Background: C57BL/6J-Ggt1enu1

 MP:0010254 nuclear cataracts "a lens opacity located in the dense, central part of the lens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Fgfr2tm3Dsn/Fgfr2tm3Dsn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012604 decreased glutathione level 
Show

Allelic Composition: Ggt1enu1/Ggt1enu1
Genetic Background: C57BL/6J-Ggt1enu1

 MP:0012606 increased glutathione level 
Show

Allelic Composition: Ggt1enu1/Ggt1enu1
Genetic Background: C57BL/6J-Ggt1enu1

 MP:0013730 glutathionuria "elevated concentrations of the reducing agent glutathione in urine" [MGI:llw2]
Show

Allelic Composition: Ggt1enu1/Ggt1enu1
Genetic Background: C57BL/6J-Ggt1enu1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006345 Ggt1 / Q60928 / Glutathione hydrolase 1 proenzyme Glutathione hydrolase 1 heavy chain Glutathione hydrolase 1 light chain / GGT2* / Q9BX51* / GGTLC3* / P19440* / P36268* / Q14390* / B5MD39*...  / complex






 

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